Why did they opt for an mRNA COVID vaccine as opposed to using said mRNA to generate the viral antigens and inject those instead? | AskScience Blog

Pages

Friday, November 27, 2020

Why did they opt for an mRNA COVID vaccine as opposed to using said mRNA to generate the viral antigens and inject those instead?

Why did they opt for an mRNA COVID vaccine as opposed to using said mRNA to generate the viral antigens and inject those instead?


Why did they opt for an mRNA COVID vaccine as opposed to using said mRNA to generate the viral antigens and inject those instead?

Posted: 26 Nov 2020 04:10 PM PST

I'd figure the viral antigens themselves would be a lot more stable than mRNA and maybe not need to be stored at such extremely cold temperatures.

Since everybody is getting the same mRNA and thus generating the exact same viral antigens, why not just produce the antigens in situ (or in vivo with COVID-infectable animals), purify the viral antigens, and ship those as the COVID vaccine?

submitted by /u/Pheophyting
[link] [comments]

AskScience AMA Series: Hello, I'm Dr Pen-Yuan Hsing from the University of Bath in the United Kingdom & have worked in ecology/conservation, founded a citizen science wildlife-monitoring project and am also an active open science/open source advocate. Ask me anything!

Posted: 27 Nov 2020 04:00 AM PST

Hi Reddit, I'm Dr Pen-Yuan Hsing from the University of Bath in the United Kingdom.

For most of the past 10+ years I did ecological field research from the savannahs of South Africa, hydrothermal vents near Papua New Guinea, to the bottom of the Gulf of Mexico in a submarine (to study impacts from the Deepwater Horizon oil spill). I've also organised many science outreach events like Ustinov Science Day or a Durham Wildlife Trust Field Trip over the years.

About 5 years ago, I co-founded the MammalWeb project where citizen scientists work together to capture wildlife images with motion-sensing cameras to improve our understanding of wildlife diversity and distribution. Check out these example photos & videos. MammalWeb's civic engagement has even been featured in The Guardian!

As is the case for many scientists, I had to learn programming for data science and got to work with talented developers/civic hackers from the hacker/maker community. I'm now also a strong advocate for open science, open source, and free culture (emphasis on freedom, not "free of charge") and want to work with others to expand the circle of liberty for knowledge and innovation. Please Ask Me Anything!

I will be here to answer questions at 7pm GMT (2 PM ET), ask me anything!

If you have any feedback on this Reddit AMA please fill out our short google form: FUTURES2020 Pop-Up Poll

Username: u/UniversityofBath

submitted by /u/AskScienceModerator
[link] [comments]

What is the relative speed of a photon to a moving object?

Posted: 26 Nov 2020 03:20 PM PST

Forgive me if this question sounds dumb but I am really curious.

Let us say we are traveling with 99.9% of speed of light and we release a photon in the same direction we travel. What would be the relative speed of the photon to us? If it is still speed of light, why?

And what would be the relative speed of a photon released from a moving object to another photon released from still object if released to same direction? Why cant we add up the speed of moving object and speed of light?

Thank you.

submitted by /u/blazzeth
[link] [comments]

Can alpha decay cause a fission like how a neutron can?

Posted: 27 Nov 2020 06:38 AM PST

I would like to ask if just adding 1 neutron into a nucleus cause a fission reaction, would a nucleus receiving alpha radiation decay as well?

Can a nucleus even receive /combine with the alpha particle?

I thought about this because I was told that large amount of U-235, if stored together in large quantity and close proximity, will spontaneously cause fission by itself. I then looked the decay path of U-235 and it does not have a neutron emission as a decay path.

submitted by /u/Jack____Bacon
[link] [comments]

Why is the rate of decay of radioisotopes not constant, for example like 500 g/hour but instead depends on the current mass as seen by half-life?

Posted: 27 Nov 2020 04:45 AM PST

How do pregnancy test work? Plus general questions about molecular tests.

Posted: 26 Nov 2020 12:27 PM PST

Hello, I was wondering how pregnancy tests work at the molecular level. Specifically, how the enzymes (immobilised on the strip?) aren't degraded over time and if it is all really due to capillary diffusion.

Also, I would like to know how the scientific field that study and see the development of these kind of molecular tests is named. Searching for "Molecular diagnostics" doesn't seem very revealing.

In addition, I would be very grateful if anyone could provide a sort of list of diagnostics devices that are out there. Any article or reference on the subject is very welcome.

Thank you in advance.

EDIT: grammar

submitted by /u/Masnef
[link] [comments]

Can someone with a split brain (hemispherectomy or similar) have each half of their body fall asleep at different times?

Posted: 26 Nov 2020 08:02 AM PST

How does radiation make other objects radioactive?

Posted: 26 Nov 2020 07:56 PM PST

And is it always happen regardless of dosage?

submitted by /u/NiceScents
[link] [comments]

Why are coronavirus cases increasing?

Posted: 26 Nov 2020 10:40 AM PST

Is it mainly people not wearing masks? Or people who are partying or doing large gatherings? Or is it simply we're not locked down and staying alone?

submitted by /u/mm126442
[link] [comments]

What is the difference between vaccination and getting corona through exposure to others?

Posted: 26 Nov 2020 07:18 AM PST

Truly just trying to understand - no "anti-vaxx" agenda here, but I was learning about how vaccines work and it got me wondering, if so many people have/will get corona without ever showing symptoms, what does the vaccine actually do for those people? Would their body already have the "memory" to deal with future exposure to corona? And if you're able to get corona twice, as has been suggested, how does the vaccine work around this? Thanks for any help, sorry if this is a silly question

submitted by /u/slppr
[link] [comments]

Thinking about antibiotic resistance, could there be a mechanism for some future virus to become resistant to mRNA vaccines?

Posted: 26 Nov 2020 01:37 PM PST

I keep seeing a lot of excitement over mRNA vaccine development and I agree it is a ground breaking achievement perhaps on par when Penicillin was discovered. That said and stealing a famous movie quote, "life finds a way", is the only hope for viruses to overcome a mRNA vaccine to mimic what HIV does by attacking the immune system itself or like the Herpes family of viruses of being able to hide from the immune system?

submitted by /u/zynix
[link] [comments]

Why is there still a relatively high diversity of megafauna in South and South East Asia?

Posted: 26 Nov 2020 07:29 AM PST

I read that the holocene extinction wiped out most non-bovine megafauna from most of the planet as humans spread over the Earth.

From what I understand, African megafauna evolved alongside humans leading to reasonable defense mechanisms (maybe fear of humans, I don't know). As humans swept across Eurasia, Americas, Oceania, mass extinctions of megafauna followed them.

Per my understanding, the exceptions being South Asia and South East Asia, where there is still a wide diversity of megafauna (at least compared to the rest of the planet), despite being populated by humans at similar times as the rest of Eurasia.

So my question is, what is the current explanation by anthropologists, paleontologists and biologists?

submitted by /u/sleeper_shark
[link] [comments]

Can moderate elevation differences affect health?

Posted: 26 Nov 2020 07:05 AM PST

I don't mean like living in the mountains vs in a city. But city to city- let's say one city's elevation is 70m and another city's elevation is 239 m. Is it possible that living most of your life (30 years) in the lower elevation then moving to a city with a higher elevation can affect your health? Someone I know immediately feels the changes in their body when they go from one city to the next- and that when they're in the city that has a higher elevation- they instantly feel all their health problems heightened but when they go in the other direction, the problems seem to go away or are significantly lessened.

submitted by /u/afromatic
[link] [comments]

Why do carbonation bubbles release at different speeds?

Posted: 26 Nov 2020 07:41 AM PST

I was totally geeked the other day watching my soda water bubble and noticed that within each string of bubbles they all float up at the same pace, but the different strings move at different paces. For some reason I just really want to know why? Does anyone know?

submitted by /u/Affectionate-Yam1156
[link] [comments]

Are vaccines iterated upon over time?

Posted: 26 Nov 2020 05:52 AM PST

I was wondering if vaccines were iterated and improved upon overtime. My question stems from the general worry around the covid-19 vaccine where are a few people in my circle are hesitant to be the first ones in line for the vaccine. They liken it to a tech or car product where the first version sometimes has a lot of kinks in it and it is improved upon overtime. I was wondering is it the same for vaccines. Will there be a covid vaccine v1, then v2, or are vaccines one and done where the formula for the vaccine doesn't change?

I tried to search online but I'm not sure if I'm just not asking the right question but I'm not getting results that help me better understand if vaccines have "bugs" in their first versions and are improved upon overtime

Thanks for your help!

submitted by /u/Silliestgoose
[link] [comments]

What caused this weird (5x) Exponential Spike in Triplets in US from 1986 to 1998?

Posted: 26 Nov 2020 01:12 AM PST

I was researching something else, and I came across this report by the CDC documenting various statistics about birth rates in the US.

https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_13-508.pdf

The first chart in the report documents a massive exponential spike in "triplet and higher-order multiple births" from 1986 to 1998, ultimately reaching around 5-6 TIMES the initial rate in 1986, Then it stopped, and stayed level for 5 years until 2003, and then it declined at a linear rate. As of 2018 (the last year of the report), it has still not reached the original rate, and was at roughly double the rate of 1986.

The report doesn't seem to explain it, only document it, and describe the change.

As I understand it, some aspects of human reproduction such as age of puberty, etc. are effected by environmental factors, but I'm unsure of twinning rates. Is there a reasonable explanation for this (peace/war cycles, economic boom/bust of the tech bubble, experimental pesticides, etc.)? Is this a natural cycle populations go through of sinusoidal twinning rates? Or do we have no idea what caused this?

submitted by /u/Univac1
[link] [comments]

How exactly does the doping/dedoping process in polymer-doped pseudocapacitors work?

Posted: 26 Nov 2020 08:48 AM PST

Hi!

So, I've been studying the specific case of polypyrrole doped with graphene in supercapacitors.

I know that redox reactions occur between graphene and the electrolytes, but I don't understand how exactly it happens. How is the charge transferred?

Why do pseudocapacitors lose their capacitance so easily (if compared to EDLCs)?

What exactly is the interaction between electrode/graphene and electrolytes (microscopically speaking)?

What kind of electrolytes are used?

submitted by /u/Westher98
[link] [comments]

No comments:

Post a Comment