AskScience AMA Series: We are from the Molecular Engineering & Sciences Institute at the University of Washington. The field of Molecular Engineering is novel, but it has had many impactful discoveries in fields ranging from nanomedicine to energy storage! AUA about Molecular Engineering! | AskScience Blog

Pages

Friday, November 20, 2020

AskScience AMA Series: We are from the Molecular Engineering & Sciences Institute at the University of Washington. The field of Molecular Engineering is novel, but it has had many impactful discoveries in fields ranging from nanomedicine to energy storage! AUA about Molecular Engineering!

AskScience AMA Series: We are from the Molecular Engineering & Sciences Institute at the University of Washington. The field of Molecular Engineering is novel, but it has had many impactful discoveries in fields ranging from nanomedicine to energy storage! AUA about Molecular Engineering!


AskScience AMA Series: We are from the Molecular Engineering & Sciences Institute at the University of Washington. The field of Molecular Engineering is novel, but it has had many impactful discoveries in fields ranging from nanomedicine to energy storage! AUA about Molecular Engineering!

Posted: 20 Nov 2020 04:00 AM PST

We are graduate students, staff, and faculty from the University of Washington Molecular Engineering and Science (MolES) Institute. Molecular Engineering is a new field; we were one of the first Molecular Engineering graduate programs in the world, and one of only two in the United States. Though MolES only opened in 2014, we have had many discoveries to share!

Molecular engineering itself is a broad and evolving field that seeks to understand how molecular properties and interactions can be manipulated to design and assemble better materials, systems, and processes for specific functions. Any time you attempt to change the object-level behavior of something by precisely altering it on the molecular level - given knowledge of how molecules in that "something" interacts with one another - you're engaging in a type of molecular engineering. The applications are endless! Some specific examples of Molecular Engineering research being done within the labs of the MolES Institute are:

  1. MolES faculty member and Chemistry professor Al Nelson developed a new way to produce medicines and chemicals and preserve them in portable, modular "biofactories" embedded in water-based gels known as hydrogels. This approach could enable access to critical medicines and other compounds in low-resource areas.
  2. The Baker lab in MolES and Biochemistry is engineering artificial proteins to self-assemble on a crystal surface. The ability to program these interactions could enable the design of new biomimetic materials with customized chemical reactivity or mechanical properties, that can serve as scaffolds for nano-filters, solar cells or electronic circuits.
  3. Bioengineering/MolES Institute Professor Kelly Stevens developed a new 3D printing approach to create biocompatible hydrogels with life-like vasculature - opening the possibility of printing living human tissue for things like organ replacement!
  4. Researchers in MolES and Chemical Engineering professor Elizabeth Nance's lab are attempting to deliver therapeutics to the brain using tiny nanoparticles that can effectively cross the blood-brain-barrier in brain injury and disease.
  5. As a MolES PhD student in Valerie Daggett's lab, Dylan Shea studies the molecular events that occur in the earliest stages of Alzheimer's disease to better understand the structural transitions that take place in Alzheimer's-associated proteins. This knowledge will inform the development of diagnostic tests for early pre-symptomatic detection.
  6. MolES PhD student Jason Fontana is working in the labs of James Carothers and Jesse Zalatan to develop tools that facilitate genetic engineering in bacteria for optimizing biosynthesis of valuable products.

Molecular engineering is recognized by the National Academy of Engineering as one of the areas of education and research most critical to ensuring the future economic, environmental and medical health of the U.S. As a highly interdisciplinary field spanning across the science and engineering space, students of Molecular Engineering have produced numerous impactful scientific discoveries. We specifically believe that Molecular Engineering could be an exciting avenue for up-and-coming young scientists, and thus we would like to further general awareness of our discipline!

Here to answer your questions are:

  • Alshakim Nelson - ( /u/polymerprof ) Assistant Professor of Chemistry, MolES Director of Education
    • Research area: polymer chemistry, self-assembly, stimuli-responsive materials, 3D printing
  • Christine Luscombe ( /u/luscombe_christine ) - Campbell Career Development Endowed Professor and Interim Chair of Materials Science & Engineering, Professor of Chemistry.
    • Research area: clean energy, photonics, semiconductor, polymer chemistry
  • James Carothers (/u/CarothersChem) - Assistant Professor of Chemical Engineering
    • Research area: synthetic biology, RNA systems modeling, metabolic engineering
  • David Beck ( /u/DACBUW ) - Research Associate Professor of Chemical Engineering
    • Research area: data science, software engineering, systems biology, biophysical chemistry
  • Ben Nguyen ( /u/nguyencd296 ) - First Year PhD Student
    • Research area: polymer chemistry, drug delivery
  • Nam Phuong Nguyen ( /u/npnguyen8 ) - Second Year PhD Student
    • Research area: nanotherapeutics, drug delivery, neuroscience, biomaterials
  • Evan Pepper ( /u/evanpepper ) - First Year PhD Student
    • Research area: synthetic biology, systems biology
  • Ayumi Pottenger ( /u/errorhandlenotfound ) - Second Year PhD Student
    • Research area: infectious disease, drug delivery, polymer chemistry
  • David Juergens ( /u/deepchem) - Second Year PhD Student
    • Research area: protein engineering, deep learning, data science
  • Paul Neubert ( /u/UW-Mole-PhD ) - PhD Program Advisor

We'll start to answer questions at 1PM ET (18 UT), AUA!

submitted by /u/AskScienceModerator
[link] [comments]

Has anyone studied if the COVID infection mechanism affects what symptoms you get?

Posted: 20 Nov 2020 04:47 AM PST

I haven't been able to find any articles but I've been wondering if the way you contract COVID (e.g. inhalation vs surface contact) leads to different symptoms (e.g. no taste or smell vs sore throat) or something of the sort. Please let me know if you've seen studies on this!

submitted by /u/sos-im-not-creative
[link] [comments]

How do vaccines work on transplant patients?

Posted: 19 Nov 2020 09:29 AM PST

On lots of immunosuppressants? Are they effective?

submitted by /u/freemike
[link] [comments]

How did humans eat meat before fire?

Posted: 19 Nov 2020 02:23 PM PST

What's the distance between atoms in a solid?

Posted: 20 Nov 2020 09:02 AM PST

Just wondering how close together atoms are together in a solid item or molecule. I know that electrons are far from the nucleus but say i have two atoms next to each other, are the nuclei seperated by the electrons or are the electrons just kind of interlocked and the nuclei next to eachother?

submitted by /u/SupHerMan1
[link] [comments]

Is there a theoretical lower limit to the size of a Tokamak?

Posted: 20 Nov 2020 08:23 AM PST

I've always thought that Tokamaks are underutilized as "applied phlebotium" in sci-fi. In our current understanding, is there a lower limit to the size of the torus? Or restrictions in the relation between inner and outer radii? Can I write a story set in the 24th century where the characters use Tokamaks the size of a CD to power up their suits?

Thanks in advance

submitted by /u/UndercoverDoll49
[link] [comments]

Can vaccines give the same long term effects as the virus itself?

Posted: 20 Nov 2020 05:33 AM PST

This is obviously just a hypothetical situation since we can't really know, but let's say that 10 years from now people start experience heart problems and it's traced back to people who have had Covid. Would the people who never had Covid and were vaccinated for it also have a chance at these side effects? Assuming they've not been exposed to Covid at all after vaccination.

I'm asking cause with my very limited vaccine understanding I know a vaccine is a form of the virus itself.

submitted by /u/sfgsdd
[link] [comments]

Why doesn't the ChAdOx1 Covid vaccine lead to peripheral tolerance of the spike protein?

Posted: 20 Nov 2020 06:20 AM PST

The virus leads to expression of the spike protein on healthy cells, without CD80/86 and with host cell markers shouldn't this lead to T cell anergy when peptides are presented by MHC?

submitted by /u/rkimmunology
[link] [comments]

By having your body create a protein and then attack that protein, does the Covid vaccine carry a risk of creating autoimmune disease?

Posted: 20 Nov 2020 06:18 AM PST

Since COVID-19 infections grow exponentially, is it possible to determine how far back it really began (whether in the US or elsewhere)?

Posted: 19 Nov 2020 07:49 AM PST

I ask this out of curiosity, since people speculate "I think I had it back in December 2019." In the US, initially people thought it only began in March of 2020, and later determined that some people died from it in February. If the infection rate pattern follows a mathematical curve, can we follow that backwards to an estimated time of arrival?

I also know very little of the subjects involved, but I had heard something similar in regards to other things. Please don't hurt me.

submitted by /u/DeludedOptimism
[link] [comments]

Are there tsunamis in the middle of the oceans?

Posted: 19 Nov 2020 02:04 PM PST

Or they tend to happen near of the land?

submitted by /u/rdfporcazzo
[link] [comments]

It looks like the Covid vaccine will work better if you get two shots. What will be the consequences if a lot of people don't get the second shot and anti-vaxxers won't get one at all? Is this going to be with us forever? Will fatality rates (and/or who gets hit hardest) change?

Posted: 19 Nov 2020 06:44 PM PST

How do ovarian follicles move through the cortex of the ovary?

Posted: 20 Nov 2020 02:49 AM PST

How is that possible with all the blood vessels, and theca cells around them? Do the theca cells move with them? What happens to the cells of the cortex itself?

submitted by /u/Kemo-III
[link] [comments]

Is there anywhere you can find out about the manufacturing process of the recent coronavirus vaccines?

Posted: 19 Nov 2020 05:41 PM PST

I'm not anti vax by any means, I'm just really curious.

submitted by /u/AtwellJ
[link] [comments]

How do mRNA vaccines work?

Posted: 19 Nov 2020 09:14 AM PST

What I read about mRNA vaccines says that they program your cells to produce antigens. This sounds horrifying, but I'll admit there's a lot I don't understand, and my background isn't in biology. Is this just a temporary change or will the cells be producing antigens for the rest of your life?

submitted by /u/throwwowwee
[link] [comments]

How do gas pumps know how much gas your car needs?

Posted: 19 Nov 2020 10:47 AM PST

I have always wondered this and I never understand the articles when I google it.

submitted by /u/YoungsterSP
[link] [comments]

Have any other animal hunted entire other species into extinction the way humans have?

Posted: 19 Nov 2020 05:25 PM PST

If the measles vaccine is effective (which I’m pretty sure it is) then how would isolated anti-vaxxers cause an outbreak if almost everyone is vaccinated?

Posted: 19 Nov 2020 12:07 PM PST

I was just thinking, since the vaccine at least mostly works, you should be pretty safe from measles if you've got the vaccine. So I guess I just don't get how an outbreak can happen if the majority is vaccinated.

submitted by /u/Mr_GrammarNazi
[link] [comments]

What are the nanoparticles used in vaccines like the newest Covid vaccines?

Posted: 19 Nov 2020 07:22 PM PST

Are they like nanobots? Can they be programmed? How does it all work?

submitted by /u/oroborealis
[link] [comments]

What is that sound when we yawn? Why does it only occur while yawning and not during other uses of face muscles?

Posted: 19 Nov 2020 05:15 AM PST

Why is bladder carcinoma-in-situ considered high-risk, high-grade whereas most other types of CIS seem to be treated as pre-cancerous neoplasias?

Posted: 19 Nov 2020 02:33 PM PST

What's so special or different about bladder CIS? It's usually considered more serious than a pTa tumour, and it's more aggressive and treatment-resistant/recurrent. This is counter-intuitive to the general conception of CIS being a pre-cancerous mass of cells growing in place. How is it different on a cellular and pathophysiological level?

submitted by /u/currently_
[link] [comments]

No comments:

Post a Comment