Why do the two COVID-19 vaccine candidates require different storage conditions? | AskScience Blog

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Monday, November 16, 2020

Why do the two COVID-19 vaccine candidates require different storage conditions?

Why do the two COVID-19 vaccine candidates require different storage conditions?


Why do the two COVID-19 vaccine candidates require different storage conditions?

Posted: 16 Nov 2020 05:39 AM PST

Today, news came out about the Moderna vaccine candidate, which can be stored in a normal (-20⁰C) freezer and for some time in a normal refrigerator. Last week, news came out about the Pfizer vaccine candidate, which must be stored in a deep freeze (-80⁰C) until shortly before use. These two vaccine candidates are both mRNA vaccines. Why does one have more lax storage conditions than the other?

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Why exactly are overweight people at higher risk when they get infected with COVID-19?

Posted: 15 Nov 2020 10:39 AM PST

I have seen many mentions, that being overweight is one of the risk factors to have more sever case of COVID-19. I wonder, why exactly does this happen. Is it related to the fact that overweight people are often less active (don't exercise much, have sedentary lifestyle, etc - so, for example, their respiratory system is more susceptible to the impact of the virus) or does it have something to do with being overweight in general (hormones, metabolism or something else) ?

Why do I ask: I'm overweight, I started to exercise regularly since spring and dropped about 9 kg/19 pounds so far. Such tasks like going upstairs or running are much easier now, but my weight is still above the norm for my age/height. So I wonder if I've lowered the risk of getting the severe form of covid-19. (It's just curiousity, I'll continue to follow social distancing and other rules in any case.)

Edit: Thanks for all the answers, I totally didn't expect the post to blow up. Now I have much to read, thanks to all people willing to explain. (And to some kind strangers for the awards).

And huge respect to AskScience moderators for clearing all these "because fat is bad" useless and/or insulting answers, that I see in mobile notifications.

And yes, I understand that being overweight or obese is unhealthy in general, no need to remind me about this. My question was about that particular case with covid-19. More detailed understanding of how it works, helps me to stay motivated. (The covid threat wasn't the main reason for my desire to lose weight, I have many other inner and outer reasons for that. It just happened that staying at home on lockdown helped me to start eating healthier and working out more regularly).

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AskScience AMA Series: My name is Franck Marchis, and I am a Senior Planetary Astronomer at the SETI Institute and Chief Scientific Officer at Unistellar. AMA!

Posted: 16 Nov 2020 04:00 AM PST

I am passionate about astronomy, and I have dedicated most of my research to the development of adaptive optics on large telescopes to study asteroids and search for exoplanets.

I am proud to also work for Unistellar, a private company whose goal is to create the largest network of citizen astronomers around the world, capable of reconnecting with the dark sky with a digital, smart telescope and collecting scientific data for space agencies.

I am pleased to announce new scientific results with the Unistellar network, where citizen astronomers helped derive the shape and size of an asteroid (https://seti.org/press-release/amateurs-reshape-asteroids-their-backyard). I recently did a SETI Live with citizen astronomers Rachel Knight and Brad Davis to talk about this project (https://youtu.be/lX0ff1jeF9s).

You can also confirm TESS exoplanet candidates and help astronomers to observe the sky 24/7. From your backyard, your balcony, your roof, or far away from cities you can join a network of 3,000 citizen astronomers and help us to explore the cosmos. The SETI Institute is the science partner of Unistellar.

You can connect with me at @AllPlanets (https://twitter.com/AllPlanets) on Twitter, or on my page https://www.facebook.com/RealAllPlanets at Facebook.

Links:

I'm available at 10am PST (1 PM ET, 18 UT), AMA!

Username: /u/setiinstitute

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What would average life expectancy be if there was no healthcare? No doctors, hospitals and modern medicine.

Posted: 16 Nov 2020 05:09 AM PST

Could mRNA vaccines cause auto-immune disorders?

Posted: 16 Nov 2020 08:20 AM PST

Hello everyone! With the exciting news about the mRNA vaccine efficacy I wanted to better understand how the vaccine type works - especially since it hasn't been used in humans before. Specifically I wanted to know if there is a reasonable chance for long term harm that wouldn't be caught in the initial studies during the pandemic.

My understanding is the mRNA makes its way into your cells and the cells manufacture a protein unique to the virus (in this case the spike protein). This protein is then presented on the surface of your cells and then an immune cell comes along and checks it. The immune cell will recognize the protein as foreign, assume (incorrectly?) that the host cell is infected / cancerous and tell it to kill itself.

So, my question is, assuming the above is a mostly accurate representation of how the vaccine works, should we be concerned that we are training the immune system to kill otherwise healthy cells?

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Are the different regions of the brain separated by actual boundaries, or did we just define them arbitrarily?

Posted: 15 Nov 2020 10:27 PM PST

Why are our fingerprints spirals?

Posted: 15 Nov 2020 08:43 AM PST

Would the antibodies from the pfizer covid-19 vaccine produce a positive on a covid-19 antibody test?

Posted: 15 Nov 2020 02:14 PM PST

Since the pfizer vaccine doesn't use any virus cells but altered RNA to mimic the virus' spike protein, would the antibodies produced from the vaccine show up on a covid-19 antibody test?

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Can a vaccine generate more effective antibodies than a person who had an actual infection?

Posted: 15 Nov 2020 07:59 PM PST

Why particle accelerators are so huge? Wouldn't be possible to crush particles in a smaller and spiral structure?

Posted: 15 Nov 2020 11:39 AM PST

sorry for the dumb question, my knowledge of electromagnetic fields is restricted.

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Could it be possible that someone can't produce antibodies after they are infected with COVID-19?

Posted: 15 Nov 2020 12:40 PM PST

How do they determine how many calories any specific food has?

Posted: 15 Nov 2020 10:12 PM PST

For example, a strawberry, how do we know how many calories are in a strawberry?

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If you've never got a "flu shot", could you die of (from?) the common flu?

Posted: 16 Nov 2020 01:31 AM PST

When I look at photos of the moon I see lines extending from the craters like in a star shape. What causes the lines to form like that?

Posted: 15 Nov 2020 09:15 PM PST

If the title doesn't make sense, when I zoom in on a crater, it looks like this emoji ☀️. I'm guessing that the lines are from the impact that made the crater, but why do they form like that instead of a round area around it?

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Does "concentration" have any effect on ability to learn?

Posted: 15 Nov 2020 11:56 AM PST

I would think the answer was a resounding yes, but, (and though I know this source isn't likley a good one), when I googled "can coffee make you think faster," the first answer I was given was;

"While moderate caffeine intake can boost your ability to concentrate, and improves mental alertness, it doesn't make you smarter – and has no effect on learning!"

How could improved concentration not improve one's ability to learn?

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Are there any species of animals that are extremely rare by "nature"?

Posted: 15 Nov 2020 04:00 AM PST

Or is extreme rarity caused by outside pressures such as habitat destruction and over hunting?

Thank you!

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