RNA vaccines question: Could be used to regenerate tissues? | AskScience Blog

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Sunday, November 22, 2020

RNA vaccines question: Could be used to regenerate tissues?

RNA vaccines question: Could be used to regenerate tissues?


RNA vaccines question: Could be used to regenerate tissues?

Posted: 22 Nov 2020 04:18 AM PST

I am reading about the new covid rna vaccine, and I saw the following comparison:

Brosh said that this does not mean the vaccine changes people's genetic code. Rather, he said it is more like a USB device (the mRNA) that is inserted into a computer (your body). It does not impact the hard drive of the computer but runs a certain program.

https://www.jpost.com/health-science/could-an-mrna-vaccine-be-dangerous-in-the-long-term-649253

Why we can not have RNA vaccines to regenerate for example burned skin, or even heal heart related problems?

submitted by /u/radicalrj
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Will there ever be a cure to the common cold? Or is it biologically impossible? How?

Posted: 21 Nov 2020 04:44 PM PST

Do non-black hole masses emit Hawking radiation?

Posted: 21 Nov 2020 12:28 PM PST

If I put a massive body in a black box, and didn't know whether it was a black hole or not, would I always observe Hawking radiation? Or is it something specific to black holes?

submitted by /u/Turkeydunk
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How much rock would form in 65 million years?

Posted: 21 Nov 2020 05:52 PM PST

I'm writing some fiction that requires an air of authenticity, and am wondering if there's any way to figure out how thick a rock layer at the bottom of the ocean would be that has had 65 million years to form.

For example, say it were possible to drop a car to the bottom of the ocean when the dinosaurs went extinct. Forget about pressure on the car. Let's say its in a protective bubble. I'm talking strictly how deep would it end up being in the rock bed if it were suddenly unearthed in present day.

Thanks in advance for the help.

submitted by /u/dog5and
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How big was the star that created the Crab Nebula?

Posted: 21 Nov 2020 06:59 AM PST

If an astronaut launched itself towards earth from the space station, would the be able to enter the atmosphere on their own, or would they just get stuck in orbit?

Posted: 21 Nov 2020 07:10 AM PST

Can they make changes to the vaccine while in clinical trial?

Posted: 21 Nov 2020 07:39 AM PST

Can they make adjustments in the vaccine if they already are in the clinical trial phase?

submitted by /u/Peacemyfriends
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Why is vaccine approval for COVID-19 vaccines an all-or-none proposition? It would seem that the benefit to some vulnerable groups would justify approving for them based on the evidence we have today.

Posted: 21 Nov 2020 10:55 AM PST

Why is there not a staged approval of the COVID-19 vaccine, where it gets incrementally approved for populations who are less and less at risk. So the approval is for the oldest people and those with pulmonary conditions first, based on the least amount of demonstrated vaccine safety, as the potential risk of taking the vaccine is outweighed by the benefit of not getting COVID? And the approval would work its way to younger and healthier groups as the risk gets better quantified.

We've done this before, with Gardasil. It was initially approved for use in girls because girls were the most vulnerable to the worst effects of HPV, cervical cancer. It would make even MORE sense when there's a rapid-timescale pandemic going on to start immunizing as many people as soon as the benefits outweigh the risks to that particular group.

submitted by /u/justpassingthrou14
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After the limited, local cooling of a "nuclear winter" finishes following a nuclear exchange, what are the long-term climate, weather, and ecological changes that are expected to take place?

Posted: 20 Nov 2020 10:49 PM PST

Why is positive lightning associated with human activities like rocket launches?

Posted: 20 Nov 2020 10:47 PM PST

According to this article. Is it just because rockets go into the sky and the positive charges in clouds are higher than the negative charges? Or do rockets tend to be net-negatively charged as they leave the launchpad?

submitted by /u/mkdir_not_war
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If you are severally far sighted can you look into a mirror 1'' in front you and clearly see something at your base normal vision range through said mirror 1'' away?

Posted: 21 Nov 2020 12:55 AM PST

I am far sighted (that g though! That one too) but noticed while looking into a magnification mirror at the makeup isle in walmart that i could see my facial features far better that ever before while being far enough away that my wife said it is pretty much normal vision for her in a normal mirror. I saw my closer features which are normal for most that i have never even thought was possible to see by a human eye by getting a bored husband wim in a makeup isle view on my face at a far range but magnified, do mirrors add to basic vision while applying magnification?

submitted by /u/Hairymountainman
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Why no clinical trials for PJ34 molecule?

Posted: 20 Nov 2020 09:38 PM PST

Someone from r/AskDrugNerds suggested I try posting to this subreddit also.

I keep reading about this molecule called PJ34. It's been tested for all kinds of diseases, including stroke, heart attack, sepsis, and a bunch of cancers. Most recently, it was wiping out 90% of human pancreatic cells in mice xenografts.

https://www.oncotarget.com/news/pr/the-phenanthrene-derivative-pj34-exclusively-eradicates-human-pancreatic-cancer-cells-in-xenografts/

I DO understand it's a big jump from mice to people. And I'm skeptical of miracle cures. But pancreatic cancer patients need miracles. They don't have the luxury of waiting 2-3 years for human trials to begin. PJ34 has been around since the early 2000s. I found pig studies too.

Questions:

  • WHY haven't there been any human trials for this molecule?
  • Even without trials, there must be some info about how it MIGHT work in humans. Do they test it against human enzymes first or something?
  • How can I find updated info? The most recent stuff online is from Dec. 2019
submitted by /u/fatfreemilk9
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