At the end of the Covid-19 Vaccine trials, were the patients told what they got and the placebo group given first shot at getting the real Vaccine? | AskScience Blog

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Saturday, December 19, 2020

At the end of the Covid-19 Vaccine trials, were the patients told what they got and the placebo group given first shot at getting the real Vaccine?

At the end of the Covid-19 Vaccine trials, were the patients told what they got and the placebo group given first shot at getting the real Vaccine?


At the end of the Covid-19 Vaccine trials, were the patients told what they got and the placebo group given first shot at getting the real Vaccine?

Posted: 19 Dec 2020 12:53 AM PST

There's so much question left as to whether the vaccine will give a long lasting immunity to Covid-19 symptoms, I started wondering how the Phase 3 trials end. Does everybody find out what they got? Do they keep reporting in for a couple years? Do the placebo groups get a front of the line pass to the real vaccine? Are there still people who got the placebo walking around thinking they might be immune?

Seems to me that early data is best data, so the original vaccine group need to be monitored. If month 5 comes and suddenly a bunch of them get sick, it means the immunity didn't last long after all :(

submitted by /u/seanbrockest
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Why is the mRNA vaccine more expensive than the "classic" vaccines?

Posted: 18 Dec 2020 09:56 AM PST

My understanding of the process was, that not only the mRNA vaccines are faster to develop, but also easier to scale up in the production. But the prices are between ~20 and ~40 for the mRNA and the AstraZeneca around 4. Why is that so?

Is it only because the production process is new and the factories have to create new production lines for it?

submitted by /u/cptmauli
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Do planes have super-chargers and/or turbo-chargers like cars can? If not, why?

Posted: 19 Dec 2020 06:23 AM PST

I know nothing about planes beyond the simple rotary engine and IM curious about this. It seems like they are operating at such a speed and scale that these additions could be perfect additions as long as it was designed to not add more drag and weight than it's added worth. Even then, what if they flew at a slightly downward slope from a higher altitude? or compensate with a design generating more lift? How would they roughly impact speed and fuel efficiency?

submitted by /u/SilasTheVirous
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How exactly is mRNA internalized? Do dendritic cells take it in and express spike proteins? Do "normal" body cells manyfacture spike protein and express it or do they eject it into the extracellular space?

Posted: 19 Dec 2020 12:33 AM PST

Couldn't find this bit of information anywhere, so it'd be fantastic if you could provide a link too. Thank you!

submitted by /u/Mikolmisol
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How do the Indian-made COVID vaccines differ from their Western counterparts?

Posted: 18 Dec 2020 09:21 AM PST

Serum Institute of India has a version of the Oxford/AstraZeneca vaccine which they've called COVISHIELD.

Serum Institute of India also has a version of the Novavax vaccine which they've called COVAVAX.

Both are independently being tested in clinical trials in India.

Do these vaccines differ from their source company counterparts? If so, how? If not, why are they being re-tested in distinct clinical trials?

submitted by /u/qwertzyu
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Why do some Vaccine's require multiple doses or Boosters while some are one and done?

Posted: 18 Dec 2020 03:48 PM PST

This question isn't so much about the Flu Shot which is yearly because of all the different strains of the flu.

But it is about vaccines like COVID for example, that is 1 shot and then a few weeks later, a second shot.

Are they different substances or just 2 doses of the same? Why do some Vaccines require a 2nd dose in the future while others you get once and are done for 5-10 years.

submitted by /u/gab0607
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Does climate change cause an increase in the number of record low pressure (and high pressure) records that are being set?

Posted: 18 Dec 2020 08:28 PM PST

Are other physical properties subject to the uncertainty principle, like position and momentum are?

Posted: 18 Dec 2020 03:26 PM PST

Would it be possible to create new elements by combining different quarks?

Posted: 19 Dec 2020 12:02 AM PST

Why does the angle of the Earth's tilt matter?

Posted: 18 Dec 2020 11:03 PM PST

The Earth is an sphere. The amount of light on a sphere is not dictated by the angle it is tilted at, because its the same all around. So why does the tilt matter at all?

Edit: I am getting notifications that people are commenting but for some reason I cannot see the comments or reply, so I'll do it here.

The fact that the Earth is not in fact a sphere and is really an oval shaped thing definitely gives the tilt meaning and answers my question. It also makes me wish the Earth was not so often referred to as a sphere, a circle, a globe, because now I feel like a dumbass

submitted by /u/tacocravr
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What is the smoke in a smokemachine made from? And how is it produced in the machine?

Posted: 18 Dec 2020 09:55 AM PST

How do the mRNA vaccines effectively enter cells for eventual translation?

Posted: 18 Dec 2020 05:32 PM PST

I was just curious at how the genetic material enters the cells. Is there a known signaling event for endocytosis to occur?

submitted by /u/KvToXic
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How are yachts able to sail faster than the wind?

Posted: 18 Dec 2020 12:17 AM PST

So I am watching America's Cup racing in New Zealand and the yachts achieve a speed of 49 knots in a 12 knot wind. How is the extra speed generated?

submitted by /u/UmthuMhlope
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Why don't we store the heat energy in the air as electricity? In this way, we could both cool the room air and obtain electricity. We would not increase global warming to generate energy, but rather cool the world.

Posted: 18 Dec 2020 11:50 AM PST

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