AskScience AMA Series: Got questions about vaccines for COVID-19? We are experts here with your answers. AUA! | AskScience Blog

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Tuesday, December 15, 2020

AskScience AMA Series: Got questions about vaccines for COVID-19? We are experts here with your answers. AUA!

AskScience AMA Series: Got questions about vaccines for COVID-19? We are experts here with your answers. AUA!


AskScience AMA Series: Got questions about vaccines for COVID-19? We are experts here with your answers. AUA!

Posted: 15 Dec 2020 06:00 AM PST

In the past week, multiple vaccine candidates for COVID-19 have been approved for use in countries around the world. In addition, preliminary clinical trial data about the successful performance of other candidates has also been released. While these announcements have caused great excitement, a certain amount of caution and perspective are needed to discern what this news actually means for potentially ending the worst global health pandemic in a century in sight.

Join us today at 2 PM ET (19 UT) for a discussion with vaccine and immunology experts, organized by the American Society for Microbiology (ASM). We'll answer questions about the approved vaccines, what the clinical trial results mean (and don't mean), and how the approval processes have worked. We'll also discuss what other vaccine candidates are in the pipeline, and whether the first to complete the clinical trials will actually be the most effective against this disease. Finally, we'll talk about what sort of timeline we should expect to return to normalcy, and what the process will be like for distributing and vaccinating the world's population. Ask us anything!

With us today are:

Links:

submitted by /u/AskScienceModerator
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How does hormonal birth control impact the onset of menopause?

Posted: 14 Dec 2020 04:33 PM PST

The main action of my hormonal birth control (nexplanon implant) is to prevent ovulation. I know that women are born with a set number of oocytes arrested in the first meiotic division and then those oocytes complete their first round of meiosis just prior to ovulation. From my understanding, this keeps happening until you reach menopause.

What I am wondering is if, by preventing ovulation, I will not deplete my store of oocytes and therefore have oocytes until later in life... Asked another way, does taking hormonal birth control delay the onset of menopause? If so, by how long?? I don't know any 60+ year old women that still menstruate so I'm guessing there is some other process going on but I'm curious.

submitted by /u/betancou1586
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Since there is no gravity at the center of the earth, does it experience gravitational time dilation?

Posted: 15 Dec 2020 07:10 AM PST

Who first discovered in the ancient world that stars produce their own light like the sun ?

Posted: 14 Dec 2020 05:04 PM PST

Did the Ancient Greeks know about it?

submitted by /u/SnooLobsters7431
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We know that cats can get coronavirus and quickly recover after about 3 days. But can they also transmit coronavirus to humans?

Posted: 14 Dec 2020 10:57 PM PST

For clarification, I mean house cats. Our pets.

submitted by /u/BowelMan
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How does the cell synthesize all of the proteins of a protein complex at stoichiometric ratios/numbers? (eg synthesize all proteasome proteins at the appropriate ratios to which they are used)

Posted: 14 Dec 2020 04:09 PM PST

Does the moon have the proper nutrients in its surface "soil" to grow plants?

Posted: 14 Dec 2020 05:16 PM PST

If we dragged in a bunch of lunar dirt to a pressurized area and planted something like wheat grain into it, then added a bunch of earth soil bacteria into it, would the plant be able to healthily grow in the soil?

submitted by /u/RedCommunistOctopus
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Why does the El Nino Southern Oscillation occur?

Posted: 14 Dec 2020 11:19 PM PST

I understand the basic mechanisms of sea surface and air temperature changes affecting rainfall on either side of the Pacific, but I want to know why the Pacific has an oscillation to begin with. Why does is oscillate rather than remain fairly even on both sides. My quick internet searches turn up very little, and while I'm able to read scientific papers on the matter, I don't exactly enjoy it. Is it just one of those things were we go "not sure, probably a wide range of factors so small and complex that we can't really pin it down" or? Thanks :)

submitted by /u/Kezza92958
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Why does the pitch of a sound lower when a video is slowed down?

Posted: 14 Dec 2020 02:25 PM PST

When slowing down a video, why do noises sound lower than they do at normal speed, and vice versa? Shouldn't the noise stay at the same pitch but just be slowed?

submitted by /u/se7en51ns
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Why did the 2009 Vaccine in sweden against the swine flu cause those bigger problems?

Posted: 14 Dec 2020 12:28 PM PST

I've asked this question before in r/explainlikeimfive but they don't want ongoing topics like this on there so here it is again:

In Sweden, in 2009, about 5 million people got vaccinated against the swine flu and to my knowledge about 400 of them suffered from that point onwards with narcolepsy. Explain me how that exactly worked out and where the problem was.

Disclaimer: If you are just a reader and not an answerer you should be aware that they used the old school version of a vaccine, unlike most current covid vaccines in the later stages. Also there was some kind of immune booster in it (which seems currently not be a thing in covid vaccines), which was apperently very strong that might had to do with it, but i am hoping for more info here too, on how and why. And lastly it might have had partly to do with genetics, too. More infos or explanations here a welcome, too.

Edit. Spelling

submitted by /u/Lugex
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Is there a significant risk to being vaccinated with BNT162b2 while having an active COVID infection?

Posted: 14 Dec 2020 03:45 PM PST

Hi, I have a few questions. I know this is an unlikely scenario, but am just curious.

  1. Is there any significant risk to being vaccinated while COVID positive?
  2. Is there any risk to be vaccinated while having asymptomatic COVID?
  3. Will people be tested before receiving the vaccine?

Question #1 and #2 may be the same question, but I included #2 because there may be some people who are unaware that they have COVID and am assuming that the immune response in asymptomatic cases might be slightly different? (Not sure about this)

I realize that the mRNA vaccine is beneficial to those who have already had COVID in the past since it is a modRNA encoding viral spike glycoprotein and generates S-protein specific antibodies, but am specifically wondering if it could cause cytokine storms or something similar in individuals who currently have an active infection. Feel free to go into detail with an answer. I am not a medical professional but have been studying microbiology a little bit recently and would like to learn from your answers.

Edit: Speculation is okay here. I'm sure there isn't much existing data on this yet.

Please feel free to correct anything I might be incorrect about. I love to learn but probably have some misconceptions since microbiology is new to me.

Btw, I'm not talking about attenuated or inert vaccines. I'm specifically referring to the BNT162b2 mRNA vaccine. I'm wondering what the potential immunological response is while simultaneously taking a vaccine and having an active infection.

submitted by /u/AKHawaii
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Is there such a thing as "evolutionary momentum" in biology?

Posted: 14 Dec 2020 03:06 PM PST

As an example, if a quadruped experiences a random mutation that slightly lengthens its legs leading to a fitness advantage, is it possible that its descendants be more likely to experience additional mutations affecting the length of their legs, or do such mutations remain stochastic?

submitted by /u/eine_zauberflote
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Is it possible for the SARS-CoV2 virus to enter the body, but NOT be able to replicate itself?

Posted: 14 Dec 2020 03:06 PM PST

Can the virus enter the body but somehow fail at binding to cell-surface receptors and be unable to replicate itself?

submitted by /u/Bolton_McThunderpecs
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If viruses have to crossover with another virus to mutate, how is COVID19 mutating so often if there aren't any viruses that are similar to it?

Posted: 14 Dec 2020 02:24 PM PST

Edit: Sorry, I made a mistake in adding that the virus mutates often which is not true, so let's just say that it mutates.

submitted by /u/DaxTom
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Will the vaccine work on new strains of the virus?

Posted: 15 Dec 2020 02:40 AM PST

With the new strain identified in South East England that has been linked to the surge in cases in London, I'm seeing a lot of discussion around the vaccine. Looking through the media I'm not really seeing a clear answer, so I thought I'd ask the straight to the point people on here.

What do you think, will the vaccine work on new strains such as the one identified in England? If someone could please explain the science in dumbed down terms that'd be even better.

I've just felt my mood plummet since hearing about this, so I'm silently praying there is some hope.


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mRNA 'vaccine' to treat other genetic conditions?

Posted: 14 Dec 2020 01:00 PM PST

So given that the Pfizer and Moderna vaccines are both mRNA which proves viability of mass manufacturing of things like this. The way I understand it these sequences are absorbed then the protein is built which then generates an immune response as it's released from the cell.

Given that same principle would it be possible to use this to treat conditions with misfolded proteins like cystic fibrosis? Especially given that CF costs on average 10-33k a year to treat, these mRNA vaccines are comparatively cheap.

Or it could be used as a cancer treatment to induce apoptosis by giving the mRNA strand with apoptosis inducing factor?

submitted by /u/Maverick__24
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Does carbon monoxide affect hemocyanin the same way it affects hemoglobin?

Posted: 14 Dec 2020 07:32 PM PST

Did the slow rotation of Venus contribute to how hot it is there?

Posted: 14 Dec 2020 02:28 PM PST

I'm just imagining that the extremely long days on Venus probably get really hot, right?

submitted by /u/cyclopean87
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Why are there no saltwater rivers?

Posted: 14 Dec 2020 07:17 PM PST

Where was the Pfizer vaccine created?

Posted: 14 Dec 2020 11:54 AM PST

I've been seeing different things from different people about where the Pfizer vaccine was created, with some saying that America made it first, or that germany was the first to make it. I know that Pfizer is an american company, but also that BioNTech, who is a german company, was working with Pfizer to develop the vaccine.

submitted by /u/Jokerrules4ever
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Do people who received a placebo vaccine ever find out they got the placebo?

Posted: 14 Dec 2020 08:47 AM PST

I ask because with this covid 19 vaccine that's rolling out there's going to be people who were part of the testing who literally have no idea if they got a placebo or a vaccine. Wouldn't it be safe for everyone to make sure the one's who got the placebo eventually get the vaccine. While at the same time not wasting resources on someone who already had the vaccine.

submitted by /u/jimmy__jazz
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How did we got rid of smallpox but haven't been able to do the same for chickenpox or measles?

Posted: 14 Dec 2020 12:52 PM PST

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