Why is there an explicit line between Phase 3 and roll out of a vaccine? |
- Why is there an explicit line between Phase 3 and roll out of a vaccine?
- To what degree can the safety of previous vaccines be generalized to the Covid-19 Vaccines? How generalizable is previous safety data to a given new vaccine?
- Why doesn't pinocytosis lead to hyperhydration?
- Can diseases mutate and infect vaccinated people?
- Why is it that when you are out of water looking into it you can see through it fine, but when you are inside water looking out it’s just as reflection?
- How can lasers get hotter by going through a magnifying glass?
- Why where the vaccines for Covid created quicker than the cures?
- How do you induce leukemia in rats?
- What do monocistronic and polycistronic genes actually mean?
- What specific risks are mRNA vaccine clinical trials evaluating?
- Does sneezing help get the virus out of your body?
- Does the relative success of the neonatal origins hypothesis undermine the validity of inferences re: genetic causality in twin studies?
- What affects the duration of acquired immunity?
- I've always wondered why doesn't oil and water mix?
- How is it possible plasma can be hot or cold?
- Common cold and Coronavirus
- Does changing the mass of an ‘in flight’ projectile affect its speed?
- How much time does it take to design a vaccine? (just the first prototype, without trials)
| Why is there an explicit line between Phase 3 and roll out of a vaccine? Posted: 08 Dec 2020 06:31 AM PST With the technology of today (ease of internet access, video medicine, and smart watches, etc), Why is there an explicit "end of Phase 3 Trials"? Shouldn't it just be "begin Phase 3a" at whatever rate the vaccine can be produced, and include placebos, continue to add new phase 3a patients at the dose production rate. When the number of cases in the placebo group have become sufficient to determine efficacy and the efficacy is good move to phase 3b, just continue administering doses of the real vaccine and no more placebo, could we have been at about 10 million people vaccinated by now? When your confidence reaches a certain level, discontinue asymptomatic monitoring that requires one-to-one medical staff, and discontinue smart watch requirements, but encourage patients to continue log data if they wish. Also reduce the patient acceptance requirements. For this particular incident, the explicit dividing line between Phase 3 and rollout is costing 1000-2000 lives a day. [link] [comments]  |
| Posted: 07 Dec 2020 05:41 PM PST |
| Why doesn't pinocytosis lead to hyperhydration? Posted: 08 Dec 2020 07:01 AM PST Since cells take up fluid from outside during pinocytosis, this would eventually lead to the cell having too much fluid. But this does not happen. Why could this be? Is the explanation as simple as just saying that the cell counteracts this with exocytosis? Or maybe aquaporins play a role? [link] [comments]  |
| Can diseases mutate and infect vaccinated people? Posted: 07 Dec 2020 02:35 PM PST So I've been thinking about this for a while, and I can't seem to find any good/fulfilling answer to this question. I believe it would be easier for me to explain with a scenario, so here goes nothing: Person 1 - vaccinated for X Person 2 - not vaccinated for X Can X mutate in 2's body, so 2 can infect 1 even though 1 got the vaccine for the "original" x? Hope it makes sense. Thanks! [link] [comments]  |
| Posted: 07 Dec 2020 09:24 PM PST |
| How can lasers get hotter by going through a magnifying glass? Posted: 07 Dec 2020 03:54 PM PST Doesnt this violate conservation of etendue? Can anyone help me understand what's going on here. [link] [comments]  |
| Why where the vaccines for Covid created quicker than the cures? Posted: 08 Dec 2020 06:10 AM PST In the beginning of the pandemic the logic was that it takes way longer to develop vaccines compared to developing a cure. [link] [comments]  |
| How do you induce leukemia in rats? Posted: 08 Dec 2020 02:10 AM PST |
| What do monocistronic and polycistronic genes actually mean? Posted: 08 Dec 2020 04:08 AM PST I keep seeing that a single gene can produce many different kinds of proteins but I've also learned that eukaryotes have monocistronic genes which means a gene encodes the information for one protein only? [link] [comments]  |
| What specific risks are mRNA vaccine clinical trials evaluating? Posted: 07 Dec 2020 09:43 AM PST It's clear that COVID vaccine science is very well understood. For example, Pfizer's mRNA vaccine provides the body with the precursor to a spike protein found on the COVID-19 virus surface. The body manufactures the protein and the protein triggers an immune response. This chain of events is completely engineered: these scientists are not shooting in the dark. There is no risk of COVID infection: the virus cannot possibly be produced from mRNA alone. Clinical trials show 95% efficacy of the mRNA vaccine with a very strong statistical significance, so Pfizer must have tested the vaccine on tens of thousands of people. Now, it's finally ready for distribution. In the mean time, hundreds of thousands have died from COVID. Why is such an extensive clinical trial actually necessary? What danger could a new mRNA vaccine present aside from just *not working*? How could this danger be greater than COVID itself? [link] [comments]  |
| Does sneezing help get the virus out of your body? Posted: 08 Dec 2020 06:58 AM PST I know I sound so stupid but my sister's manager tested reactive, so I'm kinda panicking right now as she went home several days ago. I told my friends about this and they told me to sneeze "because the virus is in your nose", I thought it was dumb since I thought the virus is in our blood? I did a quick search but couldn't find any answer. Kindly explain to me asap? edit: i saw two notification but i don't see the comments when i check my post, this might have something to do with the fact that reddit is banned here in Indonesia and im using free vpn, please kindly message me instead? or do you have any solution? if you see this please just message me for real im so frustrated [link] [comments]  |
| Posted: 07 Dec 2020 01:11 PM PST |
| What affects the duration of acquired immunity? Posted: 07 Dec 2020 05:12 PM PST Textbooks go through the process of how acquired immunity works and it always ends in the body having long-lived memory T and B cells that can initiate a rapid secondary immune response the next time the same antigen is encountered. But sometimes acquired immunity fades or is even lost after some years, right? What things affect the duration of acquired immunity? Do memory cells to some specific pathogens eventually all die out, and what factors contribute to this? [link] [comments]  |
| I've always wondered why doesn't oil and water mix? Posted: 07 Dec 2020 03:37 PM PST |
| How is it possible plasma can be hot or cold? Posted: 07 Dec 2020 07:12 PM PST I know that there has to be a lot of electrical energy, but I thought when substances get cold their atoms slow down? I would think the plasma would always have to be hot. [link] [comments]  |
| Posted: 07 Dec 2020 01:57 PM PST If someone in my household catches the common cold, does that mean: - they have not been practising social distancing? Or - they have not been washing their hands regularly? Or - someone else in the household has not been following the rules? If someone catches the common cold, could they just do easily have caught Coronavirus? [link] [comments]  |
| Does changing the mass of an ‘in flight’ projectile affect its speed? Posted: 07 Dec 2020 02:31 PM PST Ignoring friction and gravity, if you throw a 100g snowball at 100kph, and it melts 10% every 10 meters, would it start to go faster? Slower? No difference? Thanks! [link] [comments]  |
| How much time does it take to design a vaccine? (just the first prototype, without trials) Posted: 07 Dec 2020 08:02 PM PST |
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