AskScience AMA Series: We're a group of scientists working on the next generation of solvents for more sustainable chemistry. Ask us anything! | AskScience Blog

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Thursday, April 15, 2021

AskScience AMA Series: We're a group of scientists working on the next generation of solvents for more sustainable chemistry. Ask us anything!

AskScience AMA Series: We're a group of scientists working on the next generation of solvents for more sustainable chemistry. Ask us anything!


AskScience AMA Series: We're a group of scientists working on the next generation of solvents for more sustainable chemistry. Ask us anything!

Posted: 15 Apr 2021 04:00 AM PDT

Solvents are used in a variety of applications - from paints and electronics to pharmaceuticals and agrochemical production. Yet, many pose a hazard to human health and the environment, which means it's more important than ever to create safer, more sustainable alternatives.

We're exploring new applications for bio-based solvents, such as Cyrene™ - a dipolar aprotic solvent that is derived from cellulose and produced in one step from levoglucosenone (LGO), a versatile chemical building block. This solvent can be used for the production and development of active pharmaceutical ingredients, the engineering of plastics and the manufacturing and recycling of electronic components.

In addition to determining new applications for Cyrene™ solvent, we're also working on further developments for other LGO derivatives. These next-gen solvents can play a crucial role in more sustainable chemistry. For example, when compared to N-methyl-2-pyrrolione (NMP) and dimethylformamide (DMF), two solvents under increasing regulatory restrictions due to their toxicity, Cyrene™ solvent offers superior performance in some applications. Additionally, its low toxicity falls well below the hazard thresholds defined by the Globally Harmonized System of Classification and Labelling of Chemicals.

Here to answer your questions about greener solvents are:

  • Dr. Jane Murray (/u/GreenJanem): I am the global head of green chemistry at Merck. I have a background in chemical research-having completed my Ph.D. at the University of York, where I researched green oxidations of organosulfur compounds using hydrogen peroxide. In my current role, I enjoy partnering with academics to introduce novel green chemistry technologies to the scientific community. I was named an Environment+Energy Leader 100 Honoree in 2020.
  • Dr. Jason Camp (/u/DrJasonCamp): I am the chief technology officer at Circa Group. Prior to joining Circa, I had over 10 years of experience as an independent academic at various UK universities, during which I conducted research and published extensively in the areas of green chemistry and sustainable solvents, including Cyrene™. In addition, I have served on the Society of Chemical industry's (SCI) Fine Chemicals Group since 2014 and am currently the secretary of the SCI's Science and Enterprise Group.
  • James Clark (/u/GreenJamesClark): I am a scientific advisor at Circa Group, professor at the University of York and director of the Green Chemistry Centre of Excellence. I have played a leading role in green and sustainable chemistry over the last 20 years, and have published over 400 related articles in that period. My activities in research, education and industrial collaboration have led to prizes and awards from the Royal Society of Chemistry, the SCI and EUChemS, as well as honorary doctorates from universities in Belgium, Germany and Sweden.

We'll be answering questions about our work on bio-based solvent developments from 11 a.m. EDT - 1 p.m. EDT (15-17 UT). Ask us anything!

submitted by /u/AskScienceModerator
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What is up with the seahorse? It looks like nature hit the random button during critter creation. Where did it evolve from? what other sea critters is it related to?

Posted: 14 Apr 2021 08:43 AM PDT

I was speaking with my son while walking our dog the other day and we agreed that most critters seem to be a variation on other critters, be it a long neck deer or a chompy water rat. When asked about seahorse however neither of us could come up with an answer. So what is up with the seahorse how did it come be? What other animals can we see that it's genetically close to?

submitted by /u/Bostonterrierpug
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Standing on a rock at the absolute edge of the Milky Way, facing away from the galaxy. What do I see above me?

Posted: 15 Apr 2021 12:13 AM PDT

For the naked eye.

Is the sky filled with stars? Do I only see light from the local cluster, or is it mostly pitch black?

Also, if you have any material on this I'd love a link.

submitted by /u/Eckoez
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We see reusable rockets landing back at the designated landing pads. It's probably undergoing very high pressure and heat during last few seconds. Are they made of pain concrete or some special material is needed to withstand the conditions repeatedly?

Posted: 15 Apr 2021 03:03 AM PDT

What does a control line in a covid test (lateral flow rapid antigen self-test) actually detect?

Posted: 15 Apr 2021 07:19 AM PDT

Does it detect just a 'buffer' solution (so that the control strips just shows that I have wetted the strip properly), or does it actually detect some chemicals from tissues (so the control line shows I have properly sampled a nasal tissue)?

I tried googling, but this is rarely mentioned (the line is just called quality control line in test materials, without mentioning which quality it actually controls) and i have found mentions of goat antichicken IgY antibody, which sounds like something that should be able to detect human tissue, but I have no idea how this should work (and why would 'antichicken' antibodies detect human tissue).

Thank you for any pointers! :)

submitted by /u/weathergraph
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When acid is added to milk,it coagulates. What’s are the reaction kinetics associated with such coagulation?

Posted: 15 Apr 2021 07:08 AM PDT

How does in vivo electrophysiology looks like / works?

Posted: 15 Apr 2021 06:56 AM PDT

Hi everyone,

I'm doing a PhD in experimental Neuroscience but my background is in Psychology, so I'm struggling to understand a few techniques that are used in animal research.

My current difficulties are with in vivo electrophysiology.

  1. What are the concrete practical stages involved in this technique (e.g. electrodes preparation, surgery for electrode implantation, ...)?
  2. What do you measure exactly with electrophysiology? Is it action potentials? And do you measure the activity of a single neuron with a single electrode? Or is it the activity of several neurons in a larger area?
  3. How are the graphs generated? I assume that each electrode will generate its own wave signal and that these signals are then averaged into a final wave?
  4. What is multichannel fiber photometry? Is it in any way similar or related to electrophysiology?

I hope that my questions make sense, I really appreciate any answer!

Thank you very much!

submitted by /u/88_Lullabi_88
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What is the most common eye prescription?

Posted: 15 Apr 2021 06:43 AM PDT

Is near-sightedness more common than over-sightedness?

Is it more common to have a slight defect (like -1.00) than a major one (like -6.00)? Why or why not?

submitted by /u/Nirogunner
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How do babies get passive immunity from breast milk?

Posted: 14 Apr 2021 02:06 PM PDT

Essentially, doesn't the baby's digestive system break down the immunoglobulins, like it would do to any other protein? How are babies protected then?

submitted by /u/LostinAU
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Why doesn’t the immune system develop antibodies to the lipid nanoparticles used in the mRNA COVID vaccines?

Posted: 14 Apr 2021 07:14 PM PDT

Hello,

One reason for potentially reduced efficacy in Adenovirus vector platforms has been speculated to be that the immune system develops antibodies to the Adenovirus vector after the first dose, thereby reducing the efficacy of the vaccine for the second dose.

With that in mind, why don't we see the same thing happening to the lipid nanoparticle used to shuttle the mRNA into the cells, in Pfizer and Moderna's mRNA vaccines?

Wouldn't the body attempt to generate antibodies against the PEG lipid nanoparticles after the first dose? I did recall reading that the lipid nanoparticle acts as a sort of adjuvant, helping drive the immune response and boosting efficacy.

I ask this because if future vaccines were to use the same lipid nanoparticle formula to shuttle mRNA, is there any theoretical risk that individuals who received the first dose of such vaccine type would have antibodies against the material?

Thanks.

submitted by /u/rockthered198
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How is interstellar reddening accounted for in calculations of the approximate age of the universe?

Posted: 14 Apr 2021 03:47 PM PDT

As I understand it, one way of calculating the age of the universe is to measure the redshift of photons coming from distant galaxies and find the universe's expansion rate. Given that interstellar dust particles scatter higher wavelengths of light and cause the light coming from galaxies to appear more red, it would make sense that this would need to be accounted for at some point. Is this observation basically uniform across the sky or does it need to be averaged across several measurements in a way that gives us the "average" redshift of light from similar distances but different locations?

submitted by /u/submersions
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Why does the moon look so big in comparison to earth when looking at the Deep Space Climate Observatory (DSCOVR) satellite images?

Posted: 14 Apr 2021 12:39 PM PDT

I want to ask why this looks so unusual. The famous photos of earth, from the moon, make earth look smaller like in this one: https://nssdc.gsfc.nasa.gov/imgcat/hires/a11_h_44_6552.gif

Then again, the photos from DSCOVR are visually much more different in composition. The series of photos I'm curious about: https://www.nasa.gov/sites/default/files/thumbnails/image/dscovrepicmoontransitfull.gif

Thanks!

submitted by /u/accidium
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anyone can comment on what happens at the edge (for lack of a better word) of our atmosphere with space? i’m having trouble understanding how you go from having air and then having “nothing” in a vacuum. isnt there some sort of interface where the two meet and what happens there?

Posted: 14 Apr 2021 02:41 PM PDT

What causes certain COVID variants to elude detection from PCR tests?

Posted: 14 Apr 2021 08:46 AM PDT

There seems to be a new French variant that's eluding existing PCR tests. So far most other variants are still yielding covid positive results if you're infected, but not this one.

Is there something to the way it mutates that causes this?

And will we need to develop new kits that will help catch these cases??

latest French variant is not detected by PCR tests

submitted by /u/noowayyyyyy
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Twin Differences in Harsh Parenting Predict Youth’s Antisocial Behavior- Questions?

Posted: 14 Apr 2021 07:45 AM PDT

(with a question mark this time. . . thanks automod)

Also not sure about the flair, I'm asking more about methodology and how people answer these questions; less about the implications of the study.

So this morning I saw a headline, "Study proves spanking causes anti-social behavior." The article was only a paragraph long and basically stated they "used twins to determine the effects of spanking and harsh treatment". Of course my first thought was "BS" you can't beat one child for science. Then I found a much longer article in which the Author says:

>What we did was we asked both of the twins and both of the parents to report how often parents physically hit their children, and also how often they yelled at them or said mean things to them.

My question is, how accurate are these "self-reporting" data studies; I can't read the full published results; not that I disagree, I just wondering how you control for lying or misremembering, and such.https://journals.sagepub.com/doi/abs/10.1177/0956797620968532?journalCode=pssa&

submitted by /u/Ilsensine
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