How does antibiotic resistance happen? What are the medical alternatives for people who have already developed it? |
- How does antibiotic resistance happen? What are the medical alternatives for people who have already developed it?
- Chiasmodon, Gulper Eels, and other species of fish that ingest prey larger than themselves are probably more sluggish with the extra weight. How do they escape predators in this engorged state?
- How do histone deacetylases (like sirtuins) affect bromodomain expression?
- Is it possible to store analog information on a microchip?
- Does Plan B have post-fertilization effects?
- Is there any "measurement" for how thick someone's accent is?
- Is the sea level rise predicted to be completely uniform across the globe?
| Posted: 11 Apr 2022 03:20 AM PDT |
| Posted: 11 Apr 2022 01:55 PM PDT |
| How do histone deacetylases (like sirtuins) affect bromodomain expression? Posted: 11 Apr 2022 01:34 PM PDT https://pubmed.ncbi.nlm.nih.gov/30110629/ https://en.wikipedia.org/wiki/Bromodomain Bromodomains recognize multiple acetylated residues (multiple residues on the gene that are "opened up" b/c histone acetylation tends to open up histones and increase gene expression [on average] => also make bromodomains more accessible). Since bromodomains require the acetylation of multiple adjacent histone sites, does this mean that histone deacetylases decrease bromodomain action nonlinearly? It seems that bromodomain inhibitors seem to have effects against cancer (b/c cancer's spread IS HELPED when chromatin opens up more, which histone deacetylases help reduce) [link] [comments] |
| Is it possible to store analog information on a microchip? Posted: 10 Apr 2022 10:41 PM PDT I'm curious about modern analog information storage, which aren't magnetic tape, optical, etc Could anyone point me to more information on this technology if it exists? I have read some about memristors and phase change storage, but that uses a special type of glass. [link] [comments] |
| Does Plan B have post-fertilization effects? Posted: 11 Apr 2022 05:19 PM PDT Hi everyone! I have been doing a lot of research recently on the way that Plan B works and have happened upon a lot of mixed information. According to a lot of current research, Plan B has been proven to have no post-fertilization effects specifically regarding an alteration of the endrometrium. However, I also happened upon a fairly recent article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102184/ That claims the following: "The mechanism of action of LNG-EC is reviewed. The drug has no ability to alter sperm function at doses used in vivo and has limited ability to suppress ovulation. Our analysis estimates that the drug's ovulatory inhibition potential could prevent less than 15 percent of potential conceptions, thus making a pre-fertilization mechanism of action significantly less likely than previously thought. Luteal effects (such as decreased progesterone, altered glycodelin levels, and shortened luteal phase) present in the literature may suggest a pre-ovulatory induced post-fertilization drug effect." The evidence seems pretty compelling to point towards the fact that pre-fertilization effects of the drug are not the sole method of pregnancy prevention, or even the most common method. As someone who believes that life begins at conception, this is troubling for me. I took a Plan B thinking it would have no adverse affects on a potential embryo that had already formed in me, and then I experienced bleeding the next few days which made me want to research more into Plan B's potential to act as an abortifacient. TL:DR: Research surrounding Plan B is highly contested, but articles such as the one above suggest that Plan B has post-fertilization effects. As someone who believes that life begins at conception this is troubling since many other sources are spreading the idea that Plan B poses no threat to an embryo. What are your thoughts on this? Why is no one talking about this? [link] [comments] |
| Is there any "measurement" for how thick someone's accent is? Posted: 10 Apr 2022 06:05 PM PDT My wife is from Brazil and very self conscious about her accent. She often asks me how thick her accent is which got me wondering if there's any measurement or specialty relating to how thick someone's accent is. [link] [comments] |
| Is the sea level rise predicted to be completely uniform across the globe? Posted: 10 Apr 2022 06:27 PM PDT Would every location experience the exact same rise? Or could any combination of underwater topography, soil/rock quality, plate tectonics, etc... make the rise different in different locations? [link] [comments] |
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