The Human Genome Project cost $2.7 billion. 20 years later, it costs <$1000 to sequence the genome. Was the cost of the project fundamentally necessary for subsequent progress, or could we have "waited" for the technology to become cheaper? | AskScience Blog

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Sunday, July 12, 2020

The Human Genome Project cost $2.7 billion. 20 years later, it costs <$1000 to sequence the genome. Was the cost of the project fundamentally necessary for subsequent progress, or could we have "waited" for the technology to become cheaper?

The Human Genome Project cost $2.7 billion. 20 years later, it costs <$1000 to sequence the genome. Was the cost of the project fundamentally necessary for subsequent progress, or could we have "waited" for the technology to become cheaper?


The Human Genome Project cost $2.7 billion. 20 years later, it costs <$1000 to sequence the genome. Was the cost of the project fundamentally necessary for subsequent progress, or could we have "waited" for the technology to become cheaper?

Posted: 12 Jul 2020 04:51 AM PDT

I'm very much a clueless layman, but I'm learning about genetics for the first time. I don't mean this in any sort of combative way–the Human Genome Project had countless benefits that we can't possibly track, and I'd imagine $2.7 billion is a trifle compared to its broader impact.

My question is just narrowly about the way that genome sequencing has dropped rapidly in cost. Was it fundamentally necessary to first use these exorbitantly pricey methods, which provided the foundation for the future research which would make it affordable? Or are the two questions inherently separate: the Human Genome Project gave us a first, initial glimpse at our mapped out genome, and then a decade later separate technological developments would make that same task much cheaper (as is commonly the case in science and technology).

The "could we have waited" in the title is probably misleading–I really don't mean any sort of value judgment (the project sounds enormously important), I purely mean "could" in a narrow hypothetical (not, "would it have been a good idea to wait", which I highly doubt).

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Does a recently administered vaccine increase your immune response overall?

Posted: 11 Jul 2020 12:28 PM PDT

So if I received a vaccine (not an immunoglobulin one) does my immune system become more active for a short time and more likely to destroy any kind of pathogen?

EDIT: I mean a very short term response. I don't suggest developing antibodies. Also, I don't imply any practical application.

submitted by /u/hut_on_a_frozen_lake
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Is there a limit for how fast a solid, liquid, or gas can change temperature?

Posted: 11 Jul 2020 04:54 PM PDT

Will the Sahara ever turn green again?

Posted: 11 Jul 2020 07:30 PM PDT

Thousands of years ago the Sahara was Savannah. And to my understanding due to Earth's tilt shifting the Sahara began to become hotter and turn to desert.

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How are tectonic fault lines locations deduced and to what accuracy are they known?

Posted: 11 Jul 2020 02:29 PM PDT

I was looking at maps of the San Andreas fault line and I don't understand what the line on maps represent.

Is it meant to estimate the tectonic plate boundaries and if so what does it mean, is the place where one plate submerges under the other?

What's the process from earthquake data to creating this line?

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Is the percentage of precipitation given by meteorologists a probability or coverage area?

Posted: 11 Jul 2020 11:39 AM PDT

I had a coworker not long ago who said she once dated a meteorologist (or meteorology major) who told her that when you see the percentage given in a weather broadcast (ie, 30% rain), that that actually means that 30% of the coverage/broadcast area is getting rain. This runs contrary to everything I've been told wherein it's just a probability of whether or not it'll rain. The only reason I am asking here, and didn't just disregard it instantly, was that the source was (supposedly) trained in the area.

submitted by /u/nobrainxorz
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Does your brain absorb information while asleep?

Posted: 11 Jul 2020 11:15 AM PDT

Does your brain absorb information while asleep

Through listening does your brain feed that information into the subconscious?

Has anyone tried this? Playing a lecture or a podcast but you fall asleep

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Is it possible for gene expression to change during your lifetime?

Posted: 11 Jul 2020 12:12 PM PDT

For context, as a kid I loved asparagus and thought the "makes your piss stink" was an unfounded myth. Then when I was about 23 I started smelling it, and it was awful.

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What annihilates particles when Quantum Fluctuations occur in a Perfect Vacuum?

Posted: 11 Jul 2020 08:09 AM PDT

From what I understand, even in a perfect vacuum, Quantum Fluctuations can still occur. So if a particle was created in a perfect vacuum by Quantum Fluctuation, what annihilates it? From my searches online, as far as I can understand, its antiparticles? But if I remember correctly, when particles and antiparticles annihilate one another, it discharges energy.
So what really is it that annihilates the particles in a perfect vaccum?
...or am I just misunderstanding something about antiparticles or Quantum fluctuation?

submitted by /u/ChaoticWriting
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What are the characteristics of a fluid at supersonic speed?

Posted: 11 Jul 2020 05:32 PM PDT

I get how Bernoulli's principle works for subsonic fluid flow, but why once it becomes sonic does it reverse. Like for a rocket engine in throat speed goes up and pressure goes down until it reaches the speed of sound, but then once it goes through the nozzle, the speed keeps going up and pressure keeps going down.

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How Eurozone controls the value of Euro given the existance of national central banks with their own policies?

Posted: 11 Jul 2020 03:21 AM PDT

In a country it's monetary policy is determined by its Central bank which changes the amount of currency in circulation and thus modifies and controls the value of its currency. How does this work in european monetary zone (eurozone)? I know there is a central european bank, but there are also national banks in each country. Given that eurozone covers wildly different countries in terms of size and economic situation, how is joint monetary policy determined? How much control does a certain country have? For example if one country would profit from devaluation, can it do anything or did they de facto give up their control over monetary politics?

submitted by /u/Ishana92
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