I've seen reports that the Pfizer coronavirus vaccine may give up to 52% protection 10 days after the first shot. Does the Moderna data suggest anything like this as well? | AskScience Blog

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Saturday, January 9, 2021

I've seen reports that the Pfizer coronavirus vaccine may give up to 52% protection 10 days after the first shot. Does the Moderna data suggest anything like this as well?

I've seen reports that the Pfizer coronavirus vaccine may give up to 52% protection 10 days after the first shot. Does the Moderna data suggest anything like this as well?


I've seen reports that the Pfizer coronavirus vaccine may give up to 52% protection 10 days after the first shot. Does the Moderna data suggest anything like this as well?

Posted: 08 Jan 2021 09:17 AM PST

In solid-state physics, how can a specific arrangement of atoms break time-reversal symmetry like in the crystal hall effect (CHE)?

Posted: 09 Jan 2021 06:29 AM PST

To my understanding, time-reversal symmetry describes that some processes can be reversible in time (e.g. a car going at a velocity of v will travel with a velocity of -v when time is reversed) and some other processes are not symmetric to time, like a cup of coffee cooling down. I read about the crystal hall effect in antiferromagnets and am a little confused as to how this effect comes about.

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How can a new variant of SARS-CoV-2 be both more infectious but not increase in pathogenicity?

Posted: 09 Jan 2021 04:37 AM PST

The data shows that the new variant of SARS-CoV-2 appears to be more transmissible but luckily not anymore deadly than the normal variants.

But if a SARS-CoV-2 variant has a mutated spike protein that allows it to be more infectious and transmissible, doesn't this mean that it's better able to get into our cells?

And wouldn't this increased ability to invade our cells necessarily also increase its ability to cause disease? In general, the more cells that become infected, the greater the disease, right?

What possible mechanisms would allow the virus to be more easily transmissible, yet have no effect on pathogenicity?

I'm looking specifically for mechanistic reasons why pathogenicity and infectiousness are seperate (ie. the spike proteins on the new variant don't break off the viral cell wall as much as other variants, so more host cells will become infected, but once it gets inside the host cell perhaps the RNA replicase the variant has isn't as effective in creating the proteins that eventually lead to severe disease?)

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If someone got severe side effects from a vaccine, would the effects of the disease be even worse?

Posted: 09 Jan 2021 04:17 AM PST

Let's say polio vaccine. A child got that vaccine, developed autoimmune encephalitis.
Had the child not taken the vaccine, but gotten the disease, would the disease run a much more severe course than usual in that child?

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Is an earthquake of a magnitude of 10,11 or 12 feasible?

Posted: 08 Jan 2021 09:43 PM PST

If so, what would the collateral damage of such a massive earthquake entail? Does it have the potential to cause mass extinction?

I feel like a magnitude of 10 earthquake would cause a lot of damage but certainly wouldn't wipe out life on Earth, right?

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How are vaccines and other drugs tested in children?

Posted: 08 Jan 2021 04:51 PM PST

Children can't consent to medicine trials the same way that adults can, so how do drug developers test the safety and efficacy of drugs in children?

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Moderna mRNA vaccine, does it change your genome?

Posted: 09 Jan 2021 07:36 AM PST

I know that mRNA goes to the ribosome to create proteins and this mRNA has been designed to produce spike proteins so your immune system can make antibodies. But I've heard online that the mRNA could actually end up changing your genome, like how a herpes virus can infect a hosts genome and remain dormant in the hosts cell for a long time. Do you think there is reason to worry about this? I'm asking because my mom is a teacher and I'm worried that the vaccine hasn't been tested enough and she's going to be a human guinea pig.

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Since they are considering no reserve vaccines, what happens if someone isn't able to get their second dose at the right time? Can the just get it after a couple months, or will the have to get both doses again to get the full effect?

Posted: 08 Jan 2021 06:42 PM PST

Topographers: how is topographical data stored?

Posted: 08 Jan 2021 09:09 PM PST

What is underneath the sand at the bottom of the ocean?

Posted: 08 Jan 2021 12:10 PM PST

For there to be sand at the bottom of the ocean, that would mean there is something holding it up. What is it? Or maybe to better phrase the question "What was the ocean floor made of before sand?"

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How do we know the rate at which atomic clocks lose time?

Posted: 08 Jan 2021 02:04 PM PST

If they are the most accurate means of measuring time, what are they being compared to when we say they drift x seconds in y million years etc.

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Where is degree Celsius officially defined?

Posted: 09 Jan 2021 03:35 AM PST

We all know that the tripple point of Water is defined to be 273.16K or 0.01°C. Ok, was, but lets not get into that detail. BIPM, and with that most of the world, adopted the Kelvin scale (defined by the absolute zero and the triple point of water) as the temperature scale (adopted by CGPM-9). But there seems no re-definition of the Celsius scale after Kelvin got adopted as temperature scale in CGPM-10, nor when later the scale got clarified/redefined in CGPM-13.

While we all base Celsius upon Kelvin, I was not able to find any formal or legal definition of this.

So, where is the Celsius scales, that the NMIs use for calibration of instruments, officially defined?

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How likely are you to get infected with COVID-19 from your own hair if you practice social distancing?

Posted: 08 Jan 2021 05:27 PM PST

I have fairly long hair and a beard and I am wary to wash it every day because I don't want to dry out the strands. I have been washing it every time I leave my condo, but as I'm growing it out, it's getting very dry/split ends and I'm trying not to trim it any more than every six months. I have been meticulously practicing social distancing, but some instances of possible exposure are unavoidable, as I work in a high volume business and live in a condo and use the elevator. I searched online and there was not a lot of insight as to what the actual odds are of getting infected from your hair, but some doctors erred on the side of caution and advised washing hair daily. I was wondering if rinsing hair every night under lukewarm water with a high pressure shower head for several minutes and conditioning regularly would rinse out any latent Covid particles. Obviously after work I plan on using shampoo, but if I hop in to the elevator and go up to the laundry room of my building, am I super likely to contract Covid from being in the elevator and shared laundry area? I'm also very careful about disinfecting/washing my hands neurotically after touching any surface that anyone else may have touched. I also am extremely cognizant not to touch my hair or face if my hands might be contaminated. I guess my biggest worry would be going to bed at night with the possibility of having Covid on my hair, rubbing it onto my pillow, and then breathing it in from there.

Can I relax with shampooing my hair everyday or does leaving it unwashed greatly elevate my risk of contracting the virus?

submitted by /u/danubian-prince
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How effective are two dose vaccines if you get the second dose long after the recommended time interval?

Posted: 08 Jan 2021 01:58 PM PST

This has become relevant due to Biden's plan to release COVID-19 vaccines that were being previously reserved as second doses.

https://www.cnn.com/2021/01/08/politics/biden-vaccine-strategy/index.html

Let's say you receive the first dose of a vaccine and it is recommended to get the second dose one month later. But instead you do not receive the second dose for multiple months or even a year later. How does that impact the effectiveness of the vaccine after receiving the second dose? Do you have to start the dosing schedule over again (i.e. receive a third dose at the correct time interval after the second dose) to achieve immunity?

Obviously there isn't data yet to understand how this would impact COVID-19 vaccine effectiveness. But I'm wondering if there is data on other vaccines that can be used for comparison.

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Do any doctors have a guesstimate about how long until Moderna and Pfizer roll out their vaccines?

Posted: 09 Jan 2021 12:57 AM PST

Like how long does it take them to produce it and how much can they produce at any given time.

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Why Does the COVID-19 Vaccine Cause Such a Robust Symptomatic Immune Response?

Posted: 08 Jan 2021 12:13 PM PST

I got my COVID vaccine yesterday at 5 pm, and this morning woke up with a headache, malaise, and significant shoulder pain. But I get the flu vaccine every year, and I only get mild shoulder aches, and when I give teenagers vaccines for HPV, TDaP, and meningitis, they also don't get much more than mild muscle aches at the site of injection the next day.

And I'm not an isolated case. Most of my co-workers report about 24 hours of these headaches, malaise, and arm pains after getting the vaccine before it self-resolves.

I am aware that my body is mounting an immune response. But why is it so much more symptomatic than the reaction to other vaccines?

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Why do batteries shut down even when they have a little bit more power on them?

Posted: 08 Jan 2021 07:56 PM PST

Why do batteries seemingly have some juice still in them when they die? For example, when a phone runs out of battery you can try to turn it on again. It might die right on the boot or even once it's turned on if you're lucky (It actually depends on the firmware, some don't try to turn but it's clear that they still have a bit of power left).

Why do manufacturers do this? Is this some property of the li-ion architecture? Is this some design choice, maybe to increase battery life? Why not let the user choose to empty the battery for an emergency then?

This is a question I've had for a while and I couldn't find an answer anywhere else, so let's see what's it!

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What is the evidence that children (in particular in school settings) transmit covid less than adults?

Posted: 08 Jan 2021 07:18 AM PST

Many countries have kept their schools open on the basis that children do not transmit covid to the same degree as adults. This, in my mind, would be difficult to prove if many child carriers are asymptomatic as has also been reported. Can anyone shed light on the methodologies and significant studies that suggest children do not transmit the disease as much as adults?

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Why would adding CO2 make your blood more acidic if it always makes a HCO3- along with each H+?

Posted: 08 Jan 2021 07:53 AM PST

Hello, I have always been deeply confused by this concept for an embarrassingly long time. But if you hypoventilate and thus increase the CO2 in your blood, this will combine with H2O to make H2CO3, which then makes HCO3- and H+. why would this disassociation of H2CO3 decrease your pH? if it always adds a HCO3- along with its H+? Also why does carbonic anhydrase exist? why would your body want to make the reaction CO2+H2O=H2CO3 faster?

Thank you

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Why don’t bacteria evolve resistance to soaps like they do to antibiotics?

Posted: 08 Jan 2021 08:20 AM PST

How can we determine that, say, 5 billion years ago the universe was expanding slower than it is now and then accelerated for some reason to a faster acceleration and what caused that change?

Posted: 08 Jan 2021 06:49 AM PST

Is Ivermectin being considered/used as a treatment to the Covid-19 virus?

Posted: 08 Jan 2021 02:33 PM PST

If so, where is it being used and is it as promising as many articles have claimed? and if not in use nor being considered then why is that?

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What is the mechanism which causes electrons to drop in energy once entering a quantum well?

Posted: 08 Jan 2021 02:23 PM PST

After reading about quantum wells, I learned that electrons will wander from the larger bandgap material which sandwiches a smaller bandgap material, and then drop in energy upon entering the low bandgap material, therefore, trapping it. Which is fair enough, that makes sense.

But I haven't been able to find a resource which describes why this drop in energy occurs. Where does the excess energy from the electron go, why does it drop in energy in the first place?

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