What happens when a person contracts COVID between doses of the vaccine? | AskScience Blog

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Sunday, January 3, 2021

What happens when a person contracts COVID between doses of the vaccine?

What happens when a person contracts COVID between doses of the vaccine?


What happens when a person contracts COVID between doses of the vaccine?

Posted: 03 Jan 2021 05:49 AM PST

This was removed by the mods for being hypothetical but I imagine this has happened during trials or we wouldn't have the statistics we have. So I'm reposting it with less "hypothetical" language.

It's my understanding that the first dose (of the Pfizer vaccine) is 52% effective at preventing COVID and the second is 95% effective. So what happens if you are exposed to COVID and contract it in the 21/28 days between doses? In the trials, did those participants get the second dose? Did they get it while infectious or after recovering? Or were they removed from the study?

Asking because I just received the Moderna vaccine a few days ago and I want to know what would happen if I were to get it from one of my patients during the limbo period between doses. Thanks!

submitted by /u/kissthemoons
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How do we know how long vaccines are effective for?

Posted: 03 Jan 2021 04:43 AM PST

What I mean is, is it something that we just need to wait and observe or is there some sort of curve fitting that can be done to estimate how long the vaccine will protect you for? And how much variety is there among different people/age groups, or is it consistent for everybody?

submitted by /u/anonymous-S
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Why is the speed of light different when it travels through different media?

Posted: 03 Jan 2021 05:16 AM PST

Why is The new coronavirus strain being called a ' variant ' and is this different than a strain?

Posted: 02 Jan 2021 01:47 PM PST

Just curious about the wording I am seeing in the media, considering there were close to 30 strains early during the pandemic but never heard 'variant'. Thanks in advance.

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How viable is the UK's decision to leave 3 months between vaccine doses to attempt to vaccinate more people rather than committing to the original plan of 21 days between doses?

Posted: 02 Jan 2021 08:21 AM PST

Unsure if the wording is right in my title. I'm wondering if this firstly, will in fact mean more people are vaccinated sooner. Secondly, will the second dose of the vaccine be as effective when given 3 months after the first dose than it would be 21 days after.

submitted by /u/MariaOSullivan
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What is the difference between static pressure,dynamic pressure and stagnation pressure?

Posted: 03 Jan 2021 03:57 AM PST

I've been researching bernoullis principle and have had trouble wrapping my head around it , help would be much appreciated.

submitted by /u/IMFAILINGENGLISH
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What does it mean that earthquake happend on 0 km depth?

Posted: 03 Jan 2021 01:24 AM PST

Only thing I found out it could be an error due to badly positioned seismic mechanism, is that true?

submitted by /u/ClimbOnYou
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Why are vaccines usually administered on your arm near the shoulder?

Posted: 02 Jan 2021 09:59 AM PST

Is there a reason why we chose that muscle area? Could we get a vaccine in any other part of the body?

submitted by /u/alohapinay
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If our bodies are most comfortable at 98.6° F (or some approximation of that), why is air of the same temperature during the summer so uncomfortable for us?

Posted: 02 Jan 2021 09:24 AM PST

What does isolating a virus and culturing it mean?

Posted: 02 Jan 2021 09:31 PM PST

How does an mRNA vaccine "bypass" self-vs-nonself identification in the immune system?

Posted: 02 Jan 2021 03:09 PM PST

My (limited) understanding is that normal, healthy cells pickup the mRNA and process it through the normal protein synthesis pathway, just as though the mRNA had been transcribed from DNA. It is then presented on the surface (?) of this normal, healthy cell. I don't understand where in the process it then realizes that this created protein is nonself.

If you'll excuse the infosec analogy, the vaccine has hacked core manufacturing and slipped instructions into the queue. Trusted processes execute those instructions. How does the immune system remember or find out that these outputs from those trusted processes aren't to be trusted?

These are a few options that are circulating in my head and amplifying the internal confusion:

Does the hijacked cell suffer damage that triggers the immune response?

Is there some form of adjuvant in the mRNA message to make the cell believe it has been infected? Maybe encode a second protein that triggers a suicide path?

Is there a tag added to the synthesized protein to identify it as bad? Maybe encode it as a fusion protein with something we already recognize as bad e.g. a chicken pox surface protein?

Is the encoded protein modified so that instead of sticking to the cell it is simply exported and floats free? This would move it away from the "I'm a happy and healthy cell" tags on the surface of the hijacked cell, and ostensibly would look like the partial remains of a destroyed virus... but it would also look like any other extracellular protein.

Is there a 'passcode' appended in the normal DNA->mRNA process that the vaccine mRNA misses? A passcode system seems exploitable by viruses.

Thank you!

submitted by /u/EricJVW
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Do we know the speed of sound on different planets?

Posted: 02 Jan 2021 10:27 AM PST

counting both inside and outside the solar system, for obvious reasons planets with no atmosphere don't count

submitted by /u/MLPorsche
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Would all mRNA vaccines need two doses?

Posted: 02 Jan 2021 10:17 AM PST

Knowing that the covid vaccine needs two doses, and other vaccines don't, is the need for two doses because of the disease or because of something specific to mRNA vaccines

Also, how important is the time between the two doses? how far apart could they be and be effective

submitted by /u/CallumPenguin
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How do we know the UK COVID Variant is definitely from the UK, or could it just be the first country to have detected it?

Posted: 02 Jan 2021 07:55 AM PST

Is there some chance that it may have originated elsewhere (ie USA?) and just took a strong foothold in the UK by random chance?

submitted by /u/DowningJP
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Theoretical strength limit of nanomaterials?

Posted: 02 Jan 2021 10:45 AM PST

I was just thinking about nanomaterials, and I thought it shouldnt be to hard to calculate its upper (tensile) strength limit. For conventional materials it would be hard due to all the van der waals stuff, but for something like a singular nanotube with a defined geometry it shouldnt be to hard to calculate temsile strength/mm2. Basically just look for the weakest point, count how many bonds have to broken, multiply that with binding energy and divide that by cross section area.

Am i totally wrong or would this work?

submitted by /u/RepresentativeAd3742
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How can the artificial suns like in Korea and China be contained when the temperatures are so high? Wouldn't they melt anything that is meant to hold them?

Posted: 02 Jan 2021 02:13 PM PST

Does the repulsive part of the strong/nuclear force affect nucleons or only quarks?

Posted: 02 Jan 2021 01:59 PM PST

TIL that at distances smaller than 0.8 fm the strong force repels particles. Is this distance too small to affect protons and neutrons? Is this akin to quark degeneracy pressure?

submitted by /u/jsbachus
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Is genomic evolution (or dN/dS rate) over time higher in "more evolved" organisms (eg humans, songbirds) than in more "basal" organisms (eg reptiles, ostriches, platypuses, lungfishes)?

Posted: 02 Jan 2021 01:33 PM PST

How massive can nuclear pasta found in neutron stars be per cube cm?

Posted: 02 Jan 2021 09:58 AM PST

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