Are the vaccine efficacies for COVID vaccines able to be directly compared? | AskScience Blog

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Friday, February 5, 2021

Are the vaccine efficacies for COVID vaccines able to be directly compared?

Are the vaccine efficacies for COVID vaccines able to be directly compared?


Are the vaccine efficacies for COVID vaccines able to be directly compared?

Posted: 05 Feb 2021 12:40 AM PST

First, sorry I missed the AMA (UK based so time zone issues) hopefully someone can comment. My question: We have all heard the quoted 95% for e.g Pfizer and 70% effective for Oxford vaccines. But it looked to me like the underlying study outputs and processes make those numbers completely incomparable. For example, Pfizer only tested to confirm (by PCR) symptomatic patients, whilst Oxford tested (at least in the UK cohort) weekly regardless of symptoms, and as a result picked up a huge number of asymptomatic infections (almost half of the UK infections seen in the study) and included those in calculating its 70% figure. Surely this means that on a comparable basis the Pfizer efficacy would be much lower? How can we compare them?

submitted by /u/stickytreefrog
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How does the storing of Qubits work in Quantum Computing and what materials are used for these semi conductors?

Posted: 05 Feb 2021 03:17 AM PST

Can you mix the vaccines?

Posted: 04 Feb 2021 08:45 PM PST

With Moderna and Pfizer producing two different vaccines, what would happen if someone got a shot of one and a booster of the other? Would they counteract? Or supplement each other?

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Is it possible that viruses in any way spur evolution?

Posted: 04 Feb 2021 08:08 PM PST

I have often wondered, whether viruses in any way force an evolutionary response over time. Years ago, in high school, I learned viruses are pieces of RNA or DNA. Ever since then I've had this question, that if they infect the body in a way that causes sickness, Is it possible that they also change whatever may be passed onto children of those that survived it? Further I also wonder whether those changes go beyond just immune respones and actually cause changes that reach farther. Like the expression of certain genes etc.

So really what I'm wondering is, if there is any research into this idea, or if it even makes any sense? I have heard of research using viruses to cure certain ailments like cancer, but I'm talking about changes that, only after generations down the line are apparent.

Disclaimer: I am a complete layman and know very little but the basics about biology, and that goes double for genetics and epidemiology. This is more imagination than anything. I just always wondered whether there is anything to it.

submitted by /u/Quit-itkr
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Is poison immunity actually attainable by poisoning the body repeatedly?

Posted: 04 Feb 2021 09:47 AM PST

Do viruses mutate and become resistent to antivirotics just as like bacteria become resistent to antibiotics?

Posted: 05 Feb 2021 04:33 AM PST

If not, Is the main reason behind this that bacteria posess plasmids and other mechanisms of horisontal gene transfer?

If yes, why don't we freak out about this?

It's not a covid-related question, I'm just studying for microbiology right now and this came to mind.

submitted by /u/WendetaWasp
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Once a rocket reaches space and goes in to free fall, how do they get fuel/oxidant to flow downward towards the nozzle without thrust or gravity pulling it downward?

Posted: 04 Feb 2021 11:18 AM PST

There has to be some simple mechanism that pushes the fuel and oxidant out of the fuel tanks once they've cut their initial thrust. What is it?

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Is Brain Volume Associated With Differences in Intelligence or Cognitive Abilities?

Posted: 04 Feb 2021 03:10 PM PST

Are people with larger brain volumes more likely to have higher intelligence, better cognitive abilities, or a lower risk of dementia? Please tell me what you find. Could it actually be beneficial to have a lower brain volume? Please tell me which brain region volume is associated with higher or lower intelligence if you can. Please explain the correlation if you are able to. Please tell me what you find and please show sources if you can. Thank you.

submitted by /u/GuiltyAnimalLover
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Why is the effective temperature of a black hole inversely proportional to its mass?

Posted: 04 Feb 2021 09:55 AM PST

The typical number of flu variants and the numbers with COVID-19. Is it unusually high?

Posted: 04 Feb 2021 08:58 AM PST

I just read this story that appeared on Reuters about the British health ministry declaring that there are some 4,000 variants of COVID-19 spreading about the globe right now.

"All manufacturers, Pfizer-BioNTech, Moderna, Oxford-AstraZeneca and others, are looking at how they can improve their vaccine to make sure that we are ready for any variant - there are about 4,000 variants around the world of COVID now."

On the surface that seems alarming. My question those is how unusual is it for a flu strain to have that many variants? Is this typical or is COVID an outlier. And if so, why would it morph so often?

You can read the whole story here:

https://news.trust.org/item/20210204102538-eo787

submitted by /u/cheesy80s
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What exactly caused the Pandemrix vaccine to have links to higher rates of narcolepsy?

Posted: 04 Feb 2021 08:09 AM PST

During the 2008 Swine Flu pandemic, one of the vaccines approved in Europe (Pandemrix) was shown to have a link to higher rates of narcolepsy, particularly in children.

What was different about the Pandemrix vaccine that caused higher triggers to autoimmunity, and is there something about it that we've learned and avoid today? From what I've read, the vaccine wasn't well tested enough (hence the reason it wasn't approved in the US), but what was fundamentally different about it that caused autoimmunity triggers?

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Why is glass dust white?

Posted: 04 Feb 2021 08:06 AM PST

Can someone explain to me, why is broken glass dust white instead of being invisible?

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How do results come in for Phase 2b/3 clinical trials?

Posted: 04 Feb 2021 07:42 AM PST

How do Phase 2b/3 clinical trials work? Do they get results in on a regular basis or all at the end? If a company is ramping up manufacturing before the results are published - is this a good sign

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When and how did molecular chaperones evolve?

Posted: 04 Feb 2021 06:57 AM PST

I can't seem to find articles talking about the origins of chaperones.

All my Google searches are returning articles on diseases, endosymbiosis, and ribozymes...

Any help is appreciated!

submitted by /u/xangreRO
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Is (+)-naltrexone same as D isomer of naltrexone or D-naltrexone?

Posted: 04 Feb 2021 06:53 AM PST

What does (+)- and (-)- sign represent?

submitted by /u/Machinexa2
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Do most animals synthetize essential amino acids?

Posted: 04 Feb 2021 10:15 AM PST

We (humans) cannot synthetize essential amino acids, at least not as much as we need. One solution is to include in our diet sources of complete proteins and the most popular one is probably meat. This made me wonder, can most animals synthetize all essential amino acids? If so, why are we different in this regard? Is there a significant difference among different species? Does their diet (herbivorous, carnivorous, ...) make a difference?

submitted by /u/not-much
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Why are certain liver, bone marrow, and heart muscle cells polyploid, and how do they get that way?

Posted: 04 Feb 2021 03:30 AM PST

I get that endomitosis occurs when chromosomes are replicated but nuclei don't separate (no telophase/cytokinesis?)- and this leads to polyploidy. I've been searching online for an explanation of why certain human cells are polyploid and how this occurs/by what process, but haven't found anything at a level I can understand.

submitted by /u/FluffyStatistician3
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How accurate a human finger is to sense unevenness of surface?

Posted: 03 Feb 2021 11:01 PM PST

As example when working with engine top end rebuild you need to make sure those mating surfaces between block and cylinder head are as clean as possible before fitting cylinder head back on with gasket. Sometimes even after cleaning it spotless you can feel the surface being uneven but can't really see it

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