AskScience AMA Series: When my wife, Toby, diagnosed our infant son with type 1 diabetes 20 years ago, our lives changed forever: We devoted ourselves to his care and I began to imagine a bionic pancreas. AMA. | AskScience Blog

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Friday, April 17, 2020

AskScience AMA Series: When my wife, Toby, diagnosed our infant son with type 1 diabetes 20 years ago, our lives changed forever: We devoted ourselves to his care and I began to imagine a bionic pancreas. AMA.

AskScience AMA Series: When my wife, Toby, diagnosed our infant son with type 1 diabetes 20 years ago, our lives changed forever: We devoted ourselves to his care and I began to imagine a bionic pancreas. AMA.


AskScience AMA Series: When my wife, Toby, diagnosed our infant son with type 1 diabetes 20 years ago, our lives changed forever: We devoted ourselves to his care and I began to imagine a bionic pancreas. AMA.

Posted: 17 Apr 2020 04:00 AM PDT

I'm Ed Damiano, and for nearly 20 years I've been developing bionic pancreas technology to automate blood-sugar control.

When my infant son, David, was diagnosed with type 1 diabetes, my wife and I learned quickly how hard it was to get insulin dosing right in managing his blood-sugar levels, especially in such a small child. I began to imagine a wearable bionic pancreas that would automatically manage his blood-sugar levels without our intervention or his, when he grew up and became responsible for his own care.

Inspired by David's diagnosis, I began developing, testing, and refining bionic pancreas technology. My students, postdocs, and I began conducting experiments at Boston University testing an early version of the device running on a laptop computer in 2005. Together with our clinical collaborators at the Massachusetts General Hospital, we progressed to in-patient trials in adults and adolescents with type 1 diabetes in 2008. Between 2013 and 2018, my team at BU and our clinical collaborators conducted over a dozen outpatient and home-use clinical trials in adults and children with type 1 diabetes, testing various mobile versions of our bionic pancreas technology, which was developed and refined in my lab at BU.

In 2015, I co-founded Beta Bionics®, Inc., a Massachusetts Public Benefit Corporation that is committed to the singular mission of commercializing a bionic pancreas for people with diabetes and other disorders of blood sugar regulation. Beta Bionics licensed the bionic pancreas technology from BU in 2015. Since then, Beta Bionics has developed a purpose-built, fully integrated, wearable, closed-loop device - referred to as the iLet® bionic pancreas - that is designed to automate blood glucose control in people with type 1 diabetes. Over the past two years, the iLet® bionic pancreas has been tested in several home-use clinical trials in adults and children with type 1 diabetes. 440 adults and children with type 1 diabetes are currently being screened for enrollment into a phase 3 clinical trial testing the iLet bionic pancreas at 16 clinical sites across the US. The clinical data from this study will support a market application for the iLet bionic pancreas to the US FDA.

My story is featured in the new PBS documentary "Blood Sugar Rising," which premiered Wednesday night. You can stream the film on pbs.org or on the PBS Video App on your Smart TV. http://pbs.org/bloodsugarrising

Proof: https://twitter.com/novapbs/status/1251132578683289601
Here's a short video from the documentary, about my story: https://youtu.be/1j6rmx0De7A

Because "Blood Sugar Rising" is partnering with PBS series NOVA for outreach around the film, I'll be posting under NOVA's account: u/novapbs. I am looking forward to answering your questions about my family, my work, and about the latest medical technology being created to address the diabetes epidemic in America. I'll be answering your questions beginning at noon EDT on Friday, April 17.

NOTE: The information in this AMA is for informational and educational purposes only. Please note that I am not a medical doctor or health care provider, licensed or otherwise. Please consult with your health care provider when seeking medical advice or considering treatment.

Caution: the iLet® bionic pancreas is an investigational device, limited by federal (or United States) law to investigational use. As a work in progress, the iLet bionic pancreas is not available for sale within the United States or elsewhere.

submitted by /u/AskScienceModerator
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What’s special about hypersonic speeds?

Posted: 16 Apr 2020 10:42 AM PDT

I understand that characteristics of airflow change when it becomes super sonic (Mach 1), but what is special about specifically 5 times that speed? Is it just that just a human label or is there a physical phenomenon at Mach 5?

submitted by /u/SamTasy
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What do we know of the post-infection effects of Covid-19?

Posted: 17 Apr 2020 04:52 AM PDT

I had (suspected) covid-19 at the beginning of March however at the time the UK were only testing people who had been to China/Italy or had been exposed to a confirmed case. I wasn't severe, however had a horrible cough for the duration and a very tight chest towards the end. I was just about ready to return to work when my institution was shut down.

I've found that my lungs are still very tight when exercising (like that of an asthmatic) despite no history of this. Is there any evidence for lasting effects?

submitted by /u/RichardsonM24
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Small pox was eliminated years ago, but does it or can it still be possible that it is somewhere in nature waiting to make a return?

Posted: 16 Apr 2020 02:49 PM PDT

How do devices with batteries measure how much battery power they have left?

Posted: 17 Apr 2020 02:05 AM PDT

Can someone verify or correct me on this nuclear fusion concept?

Posted: 17 Apr 2020 05:36 AM PDT

I read it in a book years ago, and just saw a post on Fusion on this subreddit which said something different, so I'm just seeking verification on this.

I read that even with incredible temperatures and pressures required for fusion, the reason fusion occurs here is not due to the overcoming of repulsive forces.

Instead, I read that by increasing the amount of collisions by vast amounts due to high temperature and pressure, quantum tunnelling happens at a rate which allow nuclear fusion to take place even with no overcoming of repulsive forces.

Can somebody verify one way or the other?

submitted by /u/Mattobox
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Does the Earth's magnetic core emit electromagnetic waves as it rotates?

Posted: 16 Apr 2020 09:42 AM PDT

Pretty much the title - changing magnetic fields cause electromagnetic waves to be emitted. The Earth, obviously, has a magnetic field, and if I remember correctly the magnetic field does vary from place to place on the Earth's surface. So, the rotation of the Earth on its axis should cause fluctuations in the magnetic field and emit radiation - right? It's been a while since I've done anything with induction.

If the Earth did emit such radiation, would it all be contained by the Earth's atmosphere and ionosphere, or would it be able to go into space? Would it be really longwave, more than any radio wave we use?

submitted by /u/JCWalrus
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Is steric repulsion due to the Pauli exclusion principle?

Posted: 17 Apr 2020 05:09 AM PDT

I learnt a long while ago about the Lennard-Jones potential which has an attractive part due to van der Waals interactions and a repulsive part due to the Pauli exclusion principle when the charge distributions of atoms start to overlap. Now I'm taking a chemistry course and learning about nanoparticle interactions and there's pretty much the same behavior as the atoms I've learnt about before, except for some details concerning the size of nanoparticles and ligands etc. And then this thing that's supposedly the reason nanoparticles can't "touch", called the steric repulsion. According to the lecturer this is impossible to do quantum mechanical calculations on, but I'm still wondering; is steric repulsion due to the Pauli exclusion principle in some way?

submitted by /u/juliedactyl
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As per the Newton-Laplace equation, speed of sound is indirectly varied with density. What does that signify on a molecular level, why is it so?

Posted: 17 Apr 2020 03:51 AM PDT

It seems counterintuitive to me, since molecules would have to travel lesser distance before transferring energy to other molecules in a denser medium. And a LOT of people do use this logic on online forums, but it clearly contradicts the formula itself!

submitted by /u/blehblehbleh00
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Could the earth be as young as 100 million years old (radiometric dating)?

Posted: 16 Apr 2020 07:54 PM PDT

Recently, I was discussing evolution with my dad (who has a PhD in Geology) which led to the topics of radiometric dating.

My understanding is the Earth is 4.5 billion years old, give or take 50 million. I recently learned that the earliest fossil evidence on Earth is bacteria records from 3.5 billion years ago. I also believe these numbers are pretty accurate because radiometric dating is pretty accurate, at least based on my basic reading of the research on it.

This is his understanding of those points:

  1. The Earth's age could be "any age older than 100 million years old."
  2. The earliest fossil records are algae and these are 1 billion years old (if the radiometric dating is to be believe to be that precise). He also mentioned that people often claim they've found some random earlier fossil record but none of it is widely accepted by the geological community. And more specifically, that bacteria (which I thought was the earliest fossil record) can't even fossilize.
  3. Finally, that radiometric dating has too much uncertainty too it (which is why the Earth's age could be as low as 100 million rather than 4.5B). Specifically, the uncertainty lies in the fact that if radiometric dating says the Earth is 4.5B, how can we even know that the radioactive decay stays constant throughout? How can we know precisely that the some of the half-lifes get on the order of hundred of millions years old? In essence, there are far too many geological events and uncertainty to assume what we measure in the present day and in human time scales to be constant going back the history of the Earth.

What are your thoughts and understandings of those points? I'm an engineer and not at all a geological expert but I thought my understanding of those points were widely accepted.

Am I right or wrong? And right or wrong, can you suggest any reading material, resources, etc. to take a deeper dive into this stuff and hopefully convince my dad, if I happen to be correct?

submitted by /u/BLlMBLAMTHEALlEN
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The Governor of Louisiana said the antibody test for coronavirus can show results for the common cold coronavirus— can some explain how the test for positive Coronavirus (Covid19) making sure it is not just a common cold?

Posted: 16 Apr 2020 01:53 PM PDT

How are any tests done if sick with Covid19 or if after recovery of Covid19 if the Coronavirus antibody test is not able to be exclusive to an exact match to specifically Covid19?

Governor speaks of antibodies at approximately at 41:00

https://www.c-span.org/video/?471259-1/louisiana-governor-edwards-coronavirus-news-conference

submitted by /u/NoPupMills
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What happened to the energy released from all the matter/anti-matter annihilation events in the early universe?

Posted: 16 Apr 2020 07:33 AM PDT

We know there is a discrepancy in the amount of matter and anti-matter in the universe and believe that the vast majority of both that were created in the big bang annihilated each other, leaving the matter we see now. We don't know why matter dominated, but that's not my question. All those annihilation events would have released enormous amounts of energy. Where did it all go?

It's not the CMB is it? That is the energy of the big bang itself. I would imagine the energy released by 99% of the original matter/anti-matter created being annihilated would be almost as large as the CMB itself. Where is it?

submitted by /u/pmc100
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Are there any inhabited islands in the North Pacific?

Posted: 16 Apr 2020 02:38 PM PDT

I always hear about islands in the South Pacific and how they are tropical paradise destinations. But between Hawaii and Canada are there any islands that small populations live on? Any islands even?

submitted by /u/Da_b_guy
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Do all vertebrates have Blood-brain barrier (BBB)?

Posted: 16 Apr 2020 06:48 AM PDT

If not, please tell me about its revolutionary necessity.

submitted by /u/UseAirName
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How does my infrared TV remote still work when I'm pointing it in the opposite direction?

Posted: 16 Apr 2020 10:31 AM PDT

I'm currently pointing my remote in the opposite direction in a very well lit room, there is no direct line of sight from the LED to the sensor, yet the tv is picking up the button presses without issue. There are no mirrors or anything massively reflective. What's happening?

submitted by /u/Havoc_Ryder
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If tree leaves have chlorophyll in them, why are some leaves coloured red or yellow?

Posted: 16 Apr 2020 04:11 AM PDT

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