AskScience AMA Series: I'm Dr. Paul Knoepfler, stem cell and CRISPR researcher, here to talk about how you might build a real, fire-breathing dragon. AMA! | AskScience Blog

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Monday, August 26, 2019

AskScience AMA Series: I'm Dr. Paul Knoepfler, stem cell and CRISPR researcher, here to talk about how you might build a real, fire-breathing dragon. AMA!

AskScience AMA Series: I'm Dr. Paul Knoepfler, stem cell and CRISPR researcher, here to talk about how you might build a real, fire-breathing dragon. AMA!


AskScience AMA Series: I'm Dr. Paul Knoepfler, stem cell and CRISPR researcher, here to talk about how you might build a real, fire-breathing dragon. AMA!

Posted: 26 Aug 2019 04:00 AM PDT

Hello! I'm Dr. Paul Knoepfler, stem cell and CRISPR researcher. My 17 year old daughter Julie and I have written a new book How to Build a Dragon or Die Trying about how you might try to make a real, fire-breathing, flying dragon or other cool creatures like unicorns using tech like CRISPR and stem cells. We also satirically poke fun at science hype. We're here to answer your questions about our book, the science behind it, and the idea of making new organisms. AMA!

We're planning to come online at noon Eastern (16 UT), AUA!

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what rock are more prone to rockslides? how safe are conglomerates?

Posted: 26 Aug 2019 04:12 AM PDT

During an earthquake, would the shaking be more intense if one were beneath the crust?

Posted: 26 Aug 2019 07:58 AM PDT

Do spiders have concept of memory / facial recognition?

Posted: 26 Aug 2019 07:03 AM PDT

bit of a story

Last week I noticed a spider on the side of the house. I didn't kill it because they the small ones that kill little insects. Then one day i took out the step ladder which was apparently connected to the webs and accidentally destroyed parts of the web, i say sorry and go on to do my task. I came back the next day to return the ladder and see that it has rebuilt its house, but everytime i go there now i get slinged with webs. Never got slinged before i destroyed its house.

submitted by /u/ToYourMotherAskHer
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Why do Riverbeds always consist of stones and not dirt?

Posted: 26 Aug 2019 02:53 AM PDT

Like, how did the stones get there? Or did they just form there somehow because of the water?

submitted by /u/shayan012
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How do bees know when they have collected enough pollen?

Posted: 25 Aug 2019 04:21 PM PDT

I was out taking pictures of some bumble bees (American Bumble Bees if I identified them correctly) the other day and I noticed that they all appeared to be covered in pollen. So much that it was falling off some of them as they flew from flower to flower. I was wondering at what point they realized it was time to go back to the hive and unload?

submitted by /u/CJamesEd
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Are there any animal species where the male to female ratio is not very evenly split?

Posted: 25 Aug 2019 12:19 PM PDT

Why Wasn't the James Webb Space Telescope Designed to be Assembled in Space?

Posted: 26 Aug 2019 01:55 AM PDT

How does Reynolds' number work?

Posted: 25 Aug 2019 10:30 AM PDT

So from what I've studied, It seems to be the case that when R is less than 500, it's a condition for laminar flow, and if greater than 1000, it is turbulent flow.

But between 500 and 1000, a few textbooks referred to it as 'unsteady' flow. How is that different from turbulent flow? And is the Reynolds number prediction always valid? Or is it just a likely case?

submitted by /u/hyperclaw27
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Fire is part of the life cycle of many forests. It kills old trees and allows me ones to grow. What is the role of fire in the life cycle and history of fire in the Amazon forest?

Posted: 25 Aug 2019 05:38 AM PDT

Many forests, especially coniferous forest need fire as part of their life cycle. New trees can't compete with the older, taller trees and in some cases fire is required for pine cones to release their seeds.

What is the role of fire in the life cycle of the Amazon forest? As long as forest is allowed to regrow then is fire as bad as we are led to believe?

submitted by /u/RowingCox
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How much does chronic sleep deprivation affect pubertal development?

Posted: 25 Aug 2019 05:01 AM PDT

Coming from a third world nation, I made sure to work extra hard in high school to try and get accepted into a US institution for higher education. I ended up with a full ride at a fairly prestigious college, but at the cost of my own health. I must have been sleeping about 3-4 hours a day on average during weekdays and about 6-8 hours on weekends and whenever school was out. This went on from the second half of 9th grade until 4-5 months before graduation. I kinda ate a lot of junk food as well.

Now I regret it to some extent because I think it may have stunted my bone growth in terms of both height and circumference (robustness). I ended up the same height as my father (176 cm) but I am noticeably slighter in build and I feel as though I wasted a lot of my growth potential. What does science have to say?

submitted by /u/batmantsogt
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Why is the smallpox vaccine delivered with a bifurcated needle instead of a hypodermic needle?

Posted: 25 Aug 2019 01:16 AM PDT

Does sand act as a carbon filtration medium for the Earth's oceans?

Posted: 25 Aug 2019 11:04 AM PDT

Has research been done on analyzing if CNNs that classify related classes share similar feature maps?

Posted: 25 Aug 2019 10:18 AM PDT

I am aware of feature visualization research using tools such as activation maximization to approximate what types of features are captured by each feature map in a convolutional neural network (CNN). However, I do not know of papers determining if CNNs that classify related classes have similar feature maps. One example of "related" classes that are ones "subparts" of one another.

For instance, let there be a classifier called A which has "ham" as a class. Let there also be a classifier called B which has "ham sandwich" as a class. Is classifier B expected to have feature maps in its intermediate layers which identify ham? If so, can we expect classifier A to have some feature maps that are similar to those of classifer B because both need to identify what "ham" is to identify "ham sandwich?"

I know the classification isn't always as cleanly composable as this, as ham sandwich's features may have something that ham will never have (say, the ham being between two breads as the more important feature to look for) and thus classifier B may not even look for ham at all, so I am looking to see what is the current popular consensus, if any, on if classifier's feature maps for different classifiers can be related in such a manner.

Are there papers or blog posts which found specific classifiers that have these composable feature map properties with one another? If so, who are the more prominent researchers tackling this topic, and what major papers have been published discussing it?

submitted by /u/dsdsdg
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Why do people consider Gabapentin a “GABA” drug like benzos and alcohol?

Posted: 25 Aug 2019 12:42 PM PDT

According to studies online, like NCBI, Gabapentin has no activity at GABAA or GABAB receptors of GABA uptake carriers of brain. Also, it doesn't affect GABA transport or metabolism. So, why do so many consider it GABAergic?

submitted by /u/VerlanderFan_23
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How are we able to recognize people at a distance (too far to see facial features)?

Posted: 25 Aug 2019 02:58 AM PDT

So I've noticed that most people can recognize someone they know at a distance too far to see facial features. Some have told me they recognized their walk, or posture, or that they just knew and weren't sure how. Can anyone tell me what is going on here, or how we are able to do this?

submitted by /u/ChaosBetta16
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How do stimulants affect your heart rate?

Posted: 25 Aug 2019 04:26 AM PDT

When using Kirchoff's law to analyse circuits (specifically the loop rule), why is it that if the current and the loop direction are travelling in opposite ways it indicates a voltage lift?

Posted: 25 Aug 2019 12:37 AM PDT

In Alzheimer's, what effects do the enlargement of the ventricles have on the brain/CSF?

Posted: 25 Aug 2019 01:14 AM PDT

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