mRNA vaccines: what become the LNPs that cross the BBB (blood-brain-barrier)? |
- mRNA vaccines: what become the LNPs that cross the BBB (blood-brain-barrier)?
- Why are there no natural proton emissions in radioactive decay?
- What immunologically is going on to make people asymptomatic carriers of COVID-19?
- If you already have antibodies to a disease, would catching that disease afterward “boost” the antibodies allowing them to last longer than their expiration date?
- Why are lithium-ion batteries better stored in the middle of their charge versus fully charged?
- Is lift generated by friction?
- How does Neptunium decay from atomic number 93 into Plutonium atomic number 94?
- Hitting an object faster than its internal speed of sound?
- What's inside fossilised eggs?
- Is plasma the same thing as ionised gas?
- Can you train to not fall for optical illusions?
- If everyone received the flu vaccine, would variants no longer appear?
- Does the DNA in the AstraZeneca vaccine remain in the body forever?
- How does the body react to sudden removal of fat tissue?
- What is the source of the first electrical pulse in the primitive heart tube of a fetus?
- How do we know the Cambrian Explosion really was an increase in biodiversity, and not that Pre-Cambrian life was not fossilised due to soft body tissue and thus not shown in the fossil records ?
| mRNA vaccines: what become the LNPs that cross the BBB (blood-brain-barrier)? Posted: 20 May 2021 02:52 PM PDT Hello. It seems that the LNPs (lipid nanoparticles) that contain the mRNA of Covid-19 vaccines from BioNTech and Moderna do - at low doses - pass the BBB. This is mentioned by the EMA several times in their report, for example p. 54 and discussed in the comments of an article on Derek Lowe's blog. If that's indeed the case, what would happen once the mRNA + nanolipid reach the brain? Which cells would pick up the LNPs and for how long would they stay in the brain? If there is cells that can transform this mRNA in proteins, where will these proteins then go, and for how long will they stay in the brain? What about the LNPs: what can/will the brain do with the remaining lipids? Edit: any difference between Moderna and Pfizer/BioNTech on that front? Their lipid (SM-102 in Moderna's mRNA-1273 and Acuitas ALC-0315 in Pfizer/BioNTech's Cominarty) have strong similarities, but they are not exactly the same. Thanks! [link] [comments]  |
| Why are there no natural proton emissions in radioactive decay? Posted: 21 May 2021 05:25 AM PDT |
| What immunologically is going on to make people asymptomatic carriers of COVID-19? Posted: 20 May 2021 01:09 PM PDT What mechanism immunologically speaking, causes people to be asymptomatic COVID-19 carriers? Is it that the innate immune system is more capable of controlling the infection very early in certain individuals? I've asked my immunology professor and a few other medical professionals and they have all stated that it is not yet clear. I was curious if anyone has a better answer for me :) Thanks! [link] [comments]  |
| Posted: 21 May 2021 05:30 AM PDT Say that I get a vaccine that's good for a year and sometime during that year my body catches and successfully fights off that disease. Would the antibodies be able to last for another year as of me successfully fighting that disease or would the one year limit still apply based on the initial gaining of antibodies? [link] [comments]  |
| Why are lithium-ion batteries better stored in the middle of their charge versus fully charged? Posted: 21 May 2021 01:49 AM PDT How big of a difference does this make for the battery longevity? If I kept one battery fully charged and one battery at 30% charge for a long time, would there be a noticeable impact? [link] [comments]  |
| Is lift generated by friction? Posted: 21 May 2021 01:06 AM PDT I'm teaching my friend about pilot stuff a d she asked of lift was generated by friction. And honestly I've spent 3 years studying this shit and I honestly don't know. It's by the difference in pressure creating different speeds but do the different speeds literally drag the airfoil up? Cause it won't work in a vacuum but it would work in a liquid. This question is way more in-depth than I was taught. And if it's not friction then what specifically about the differences in speed/pressure make the wing produce lift. Please this girl made me question my entire career [link] [comments]  |
| How does Neptunium decay from atomic number 93 into Plutonium atomic number 94? Posted: 20 May 2021 09:30 AM PDT I'm reading The Making of the Atomic Bomb and it does explain it a little bit but I'm still very confused. The Uranium is bombarded with slow neutrons and fusion takes place as the neutron is captured and becomes Neptunium but then through alpha decay which ejects a helium nucleus which should lower the atomic number but instead increases it? I know I'm missing something here [link] [comments]  |
| Hitting an object faster than its internal speed of sound? Posted: 20 May 2021 04:44 PM PDT I know that a sonic boom occurs when an object travels through a medium faster than it's speed of sound, which is variable depending on the medium used. I am curious though for what happens when a solid object is struck and forced to move faster that it's own speed of sound. For example let's say I have a diamond in a vacuum (I want to isolate it form any other potential interactions). A sound waves travel through a diamond at 12,000 m/s. If I slam another diamond into it at 15,000 m/s (let's assume this second diamond has gradually accelerated to this speed) then the atoms at first impact will move faster than pressure waves within the diamond can travel. Will this cause a "sonic boom" within the diamond? Would this cause the diamonds to loose their structural integrity and disintegrate? If so, would any solid stuck faster than its speed of sound break down as well? [link] [comments]  |
| What's inside fossilised eggs? Posted: 20 May 2021 06:22 PM PDT This morning I was watching Dinotrux with my son and a question occured to me. Let's say that you had a complete and unbroken dinosaur egg, if you cut that egg in half, could there be any fossilised bones inside? Thanks in advance. [link] [comments]  |
| Is plasma the same thing as ionised gas? Posted: 20 May 2021 04:50 PM PDT |
| Can you train to not fall for optical illusions? Posted: 20 May 2021 12:32 PM PDT The title says it, can you not fall for optical illusions by somehow training your brain? Or is it as impossible like training to not see something that is really there?, let's say your phone or computer in which you are reading this. [link] [comments]  |
| If everyone received the flu vaccine, would variants no longer appear? Posted: 20 May 2021 01:44 PM PDT |
| Does the DNA in the AstraZeneca vaccine remain in the body forever? Posted: 20 May 2021 11:18 AM PDT In the mRNA vaccines the mRNA strands are destroyed after they create the proteins. But with the AZ vaccine the additional DNA is in the nucleolus, so does this mean when the cells are replicated they gain a copy of the additional DNA? Does this mean the body will forever be able to produce the mRNA needed to create the virus spike proteins? [link] [comments]  |
| How does the body react to sudden removal of fat tissue? Posted: 19 May 2021 09:27 PM PDT I know a tiny little bit about how the human body distributes excess fat and how it uses it, but I was just wondering how our bodies react to sudden removal of fatty tissue through something like liposuction or that freezing thing. Does it "notice" and attempt to compensate? Will it try to direct fat tissue to be stored in the places it was removed from? Please excuse inaccurate language, I'm mostly using stuff I remember from a health class I took like 5 years ago. [link] [comments]  |
| What is the source of the first electrical pulse in the primitive heart tube of a fetus? Posted: 19 May 2021 08:36 PM PDT I tried googling it but I was only able to find a response that said it was spontaneous. Thanks in advance. [link] [comments]  |
| Posted: 19 May 2021 03:01 PM PDT I've seen and heard countless times that the Cambrian explosion was an increase to biodiversity, but I thought not much was known Pre-Cambrian and before due to soft body tissue organisms only forming fossils increadably rarely. So how do we know the boom was an increase, and there wasn't as much bio-diversity beforehand ? [link] [comments]  |
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