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Saturday, December 19, 2020

At the end of the Covid-19 Vaccine trials, were the patients told what they got and the placebo group given first shot at getting the real Vaccine?

At the end of the Covid-19 Vaccine trials, were the patients told what they got and the placebo group given first shot at getting the real Vaccine?


At the end of the Covid-19 Vaccine trials, were the patients told what they got and the placebo group given first shot at getting the real Vaccine?

Posted: 19 Dec 2020 12:53 AM PST

There's so much question left as to whether the vaccine will give a long lasting immunity to Covid-19 symptoms, I started wondering how the Phase 3 trials end. Does everybody find out what they got? Do they keep reporting in for a couple years? Do the placebo groups get a front of the line pass to the real vaccine? Are there still people who got the placebo walking around thinking they might be immune?

Seems to me that early data is best data, so the original vaccine group need to be monitored. If month 5 comes and suddenly a bunch of them get sick, it means the immunity didn't last long after all :(

submitted by /u/seanbrockest
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Why is the mRNA vaccine more expensive than the "classic" vaccines?

Posted: 18 Dec 2020 09:56 AM PST

My understanding of the process was, that not only the mRNA vaccines are faster to develop, but also easier to scale up in the production. But the prices are between ~20 and ~40 for the mRNA and the AstraZeneca around 4. Why is that so?

Is it only because the production process is new and the factories have to create new production lines for it?

submitted by /u/cptmauli
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Do planes have super-chargers and/or turbo-chargers like cars can? If not, why?

Posted: 19 Dec 2020 06:23 AM PST

I know nothing about planes beyond the simple rotary engine and IM curious about this. It seems like they are operating at such a speed and scale that these additions could be perfect additions as long as it was designed to not add more drag and weight than it's added worth. Even then, what if they flew at a slightly downward slope from a higher altitude? or compensate with a design generating more lift? How would they roughly impact speed and fuel efficiency?

submitted by /u/SilasTheVirous
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How exactly is mRNA internalized? Do dendritic cells take it in and express spike proteins? Do "normal" body cells manyfacture spike protein and express it or do they eject it into the extracellular space?

Posted: 19 Dec 2020 12:33 AM PST

Couldn't find this bit of information anywhere, so it'd be fantastic if you could provide a link too. Thank you!

submitted by /u/Mikolmisol
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How do the Indian-made COVID vaccines differ from their Western counterparts?

Posted: 18 Dec 2020 09:21 AM PST

Serum Institute of India has a version of the Oxford/AstraZeneca vaccine which they've called COVISHIELD.

Serum Institute of India also has a version of the Novavax vaccine which they've called COVAVAX.

Both are independently being tested in clinical trials in India.

Do these vaccines differ from their source company counterparts? If so, how? If not, why are they being re-tested in distinct clinical trials?

submitted by /u/qwertzyu
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Why do some Vaccine's require multiple doses or Boosters while some are one and done?

Posted: 18 Dec 2020 03:48 PM PST

This question isn't so much about the Flu Shot which is yearly because of all the different strains of the flu.

But it is about vaccines like COVID for example, that is 1 shot and then a few weeks later, a second shot.

Are they different substances or just 2 doses of the same? Why do some Vaccines require a 2nd dose in the future while others you get once and are done for 5-10 years.

submitted by /u/gab0607
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Does climate change cause an increase in the number of record low pressure (and high pressure) records that are being set?

Posted: 18 Dec 2020 08:28 PM PST

Are other physical properties subject to the uncertainty principle, like position and momentum are?

Posted: 18 Dec 2020 03:26 PM PST

Would it be possible to create new elements by combining different quarks?

Posted: 19 Dec 2020 12:02 AM PST

Why does the angle of the Earth's tilt matter?

Posted: 18 Dec 2020 11:03 PM PST

The Earth is an sphere. The amount of light on a sphere is not dictated by the angle it is tilted at, because its the same all around. So why does the tilt matter at all?

Edit: I am getting notifications that people are commenting but for some reason I cannot see the comments or reply, so I'll do it here.

The fact that the Earth is not in fact a sphere and is really an oval shaped thing definitely gives the tilt meaning and answers my question. It also makes me wish the Earth was not so often referred to as a sphere, a circle, a globe, because now I feel like a dumbass

submitted by /u/tacocravr
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What is the smoke in a smokemachine made from? And how is it produced in the machine?

Posted: 18 Dec 2020 09:55 AM PST

How do the mRNA vaccines effectively enter cells for eventual translation?

Posted: 18 Dec 2020 05:32 PM PST

I was just curious at how the genetic material enters the cells. Is there a known signaling event for endocytosis to occur?

submitted by /u/KvToXic
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How are yachts able to sail faster than the wind?

Posted: 18 Dec 2020 12:17 AM PST

So I am watching America's Cup racing in New Zealand and the yachts achieve a speed of 49 knots in a 12 knot wind. How is the extra speed generated?

submitted by /u/UmthuMhlope
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Why don't we store the heat energy in the air as electricity? In this way, we could both cool the room air and obtain electricity. We would not increase global warming to generate energy, but rather cool the world.

Posted: 18 Dec 2020 11:50 AM PST

Friday, December 18, 2020

Question about whale blow hole muscles: are the muscles designed to keep the blowhole open or closed? Does it take more muscle to open?

Question about whale blow hole muscles: are the muscles designed to keep the blowhole open or closed? Does it take more muscle to open?


Question about whale blow hole muscles: are the muscles designed to keep the blowhole open or closed? Does it take more muscle to open?

Posted: 17 Dec 2020 06:07 PM PST

Why are their salts, sucrose and cholesterol in the covid vaccine?

Posted: 17 Dec 2020 02:38 PM PST

Just saw the list of ingredients in a subreddit and it made me wonder. Does anyone have the answer?

Edit: typo in the post. I meant "why are there salts.." thanks for all the answers!

submitted by /u/fifihihi
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How are Protons and Neutrons spherical when they're made up of three Quarks?

Posted: 18 Dec 2020 07:17 AM PST

What actually is a torque?

Posted: 17 Dec 2020 03:32 PM PST

So I ask this question at the risk of sounding stupid, but I haven't been able to find something that answers my question. Either that or I just don't get it. I' ve taken physics (and did well) and understand how to calculate torque. I understand that it is an applied force that changes rotation about an axis.

My question is what actually is the resultant vector? We know it is perpendicular and can find the direction, but what significance does that have? How does it help us understand motion? I just don't get it. Does it help predict motion? Am I overthinking it or is it talked about more in more advanced courses?

submitted by /u/wiggadillidoo
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The forthcoming 'great conjunction' - does it tell us anything we don't already know?

Posted: 18 Dec 2020 05:01 AM PST

Along with many others I'm looking forward to seeing the conjunction of Jupiter and Saturn in the next few nights. The last one was 400 years ago but couldn't really be observed as it was too close to the sun. Will this one, or similar conjunctions, be useful for any sort of scientific work or will it just be a curiosity with some public interest benefit?

submitted by /u/allthedreamswehad
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Digging a hole through earth and jump through it, you will be back in 90 minutes. 90 minutes is also the time for a low-earth orbit. Coincidence or does this happen for every object?

Posted: 18 Dec 2020 12:56 AM PST

So Neil DeGrasse Tyson claims that, when you drill a hole through earth and you throw something in it, it will pass its core get out of the other side and when no one grabs it, it will fall back to the "thrower" in 90 minutes. I have a few questions about this:

- How does it have all the energy to get back to its initial position? Shouldn't it be slowing down once it's pass the core and never get out completely of the other end of that tunnel? Same with the pendulum experiment it will not come back to you if you just let it drop. On top of all that, wouldn't air resistance also slow it down? I think NDT means without air resistance.

- How come both things (orbit and through hole) take 90 minutes? Is this a coincidence or does this also occur for the moon? the sun? (I know not 90 minutes but the thing through hole and an orbit)?

Heres NDTs video:

https://www.tiktok.com/@neildegrassetyson/video/6891365019183746310?lang=en

thanks guys.

submitted by /u/vemelon
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Is there any substantial evidence to support the notion that house cats take on the personalities of their owners?

Posted: 17 Dec 2020 06:00 PM PST

Is there a liquid that's safe to drink, that contains no amount of H20?

Posted: 17 Dec 2020 11:07 AM PST

What aspects of a pathogen does our body use to generate an immune response? Is it usually one protein or does our body usually look at multiple components?

Posted: 17 Dec 2020 03:24 PM PST

I am trying to understand the mechanism and implications of the mRNA Covid vaccine and wondering about this basic concept of its mechanism. I'm curious, is one protein normally what our body would use to generate an immune response, or do traditional vaccines or organic pathogens usually have multiple other characteristics our body identifies in the immune process?

submitted by /u/CovQuestion2
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How cold can a lithium ion battery get before it causes permanent damage or permanent loss of performance?

Posted: 17 Dec 2020 09:12 AM PST

I live in Canada and am concerned about leaving lithium-ion powered tools in the shed and garage over winter. Found a lot of info on the internet about poorer performance at freezing temperatures, but nothing about long term effects after exposure to freezing temperatures.

submitted by /u/ButternutSasquatch
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What was the process used to capture the supermassive black hole at the center of Messier 87?

Posted: 17 Dec 2020 05:45 PM PST

Now that there are more than one covid vaccines out, how fast can another drug company create a generic one?

Posted: 18 Dec 2020 02:08 AM PST

In a 4-stroke engine, after the combustion stroke completes, is the combustion chamber pressure higher than atmospheric pressure? (And isn't that extra pressure a source of wasted energy/inefficiency?)

Posted: 17 Dec 2020 02:16 PM PST

Walking through the process that a four stoke engine follows:

1.) Intake stroke - the piston moves from the top to the bottom, while the intake valve is open. This draws the fuel/air mixture into the chamber.

2.) Compression stroke - the intake valve closes, and the piston moves back to the top of the chamber, thereby compressing the fuel/air mixture.

3.) Combustion stroke - a spark ignites the compressed fuel/air mixture which combusts, forcing the piston back down to the bottom.

At this exact moment, once the piston reaches the bottom at the end of the combustion stroke, but before the exhaust valve has opened: The pressure in the combustion chamber must be higher than the atmospheric pressure. The volume of the cylinder is the exact same as the instant between the intake and compression strokes, but now, the temperature is much, much higher. So by The Ideal Gas Law (PV=nRT), the pressure must be higher, correct?

If that's true, then in the next instant, when the exhaust valve opens at the start of the exhaust stroke, that extra pressure in the chamber is vented to atmosphere. This seems wasteful and inefficient to me. That's pressure that could otherwise have been used to push the piston, right? Now, I understand that the piston already reached the bottom of its range, so it can't be pushed any further. But to eliminate this 'wasted' pressure, couldn't we have initially (on the intake stroke,) filled the chamber with slightly less of the air/fuel mixture? This could be accomplished by leaving the intake valve open for the first part of the compression stroke. So some of that air/fuel mixture is forced backwards. Then, as the compression stroke continues, the intake valve closes and compression begins. But this time, the compression ratio is slightly less since the starting volume (the volume when the chamber was sealed) is less than the full volume of the chamber with the piston at bottom dead center. Continuing on in the cycle, the piston reaches the top, where combustion occurs which forces the piston back down. As the piston moves down, the volume in the chamber is increasing, and thus the pressure is decreasing. This time however, we have only filled the chamber with enough combustible material to force the piston to the bottom of it's cycle, just as the chamber pressure reaches atmospheric pressure. Then the exhaust valve opens, and the piston rises to expel the exhaust.

Wouldn't what I have described here, be theoretically more fuel efficient compared to the conventional method of compressing the full volume of the chamber during the compression stroke?

submitted by /u/AgitateMilk
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Are bullies more successful in life than bullied people?

Posted: 17 Dec 2020 05:19 AM PST

Is there a study on that?

submitted by /u/nine_thousands
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Can Dogs sense the direction of an animal trail?

Posted: 17 Dec 2020 01:23 PM PST

When I'm walking my dog in the woods, she'll find an animal trail and follow it. As she doesn't find trails everywhere, presumably it is "fresh" - an hour? minutes? How long are animal trails followable? I have trouble believing there is enough of an odour gradient to provide direction... is there? What is being left behind by the animal (deer?) that makes it followable - something transferred from hooves?

submitted by /u/PieceOfKnottedString
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Epidemiology of the latest COVID surge... How did this happen?

Posted: 17 Dec 2020 08:16 AM PST

I have yet to find a good answer to the question of how the latest COVID surge has happened.

Mask wearing, social distancing, restricted travel, and increased hand washing have been the norm the world over. How are case rates and death rates soaring almost everywhere in the world simultaneously when all these precautions have been in place for almost the entire year and become part of daily life.

Please help me understand. Thank you!

submitted by /u/Marduk28
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How does type II diabetes lead to atherosclerosis?

Posted: 17 Dec 2020 12:51 PM PST

How does hyperglycaemia lead to atherosclerosis? Also, does hyperglycaemia lead to hypertension?

Thanks!

submitted by /u/sciencereddit3
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Is the Adrenal gland also transplanted in a Kidney transplant?

Posted: 17 Dec 2020 11:31 AM PST

Since the adrenal gland sits on the kidney, what happens to the adrenal gland of the donor and of rhe recipient?

Can humans do with one adrenal gland like we can do with one kidney?

submitted by /u/frickfrackcute
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Chernobyl Disaster - Fission without Moderator?

Posted: 17 Dec 2020 12:38 PM PST

So I'm watching the HBO series about Chernobyl which has made me read a bunch about nuclear plants and how they work - this has lead me to a series of questions that I can't seem to find answers for, which may mean they're not good questions.

My understanding is that U-235 nuclear fuel is pretty safe even in its enriched form because there's no neutron moderator present to slow down the emitted neutrons to an energy level conducive of causing fission, right?

I have a vague understanding of why the core exploded, but once the explosion happened the fuel and the moderator are both scattered at great distances atomically speaking, and I would think that the open-air would bring down the temperatures of the exposed core.

Why did the fire carry on with such intensity and why weren't they able to put it out? If they were putting boron and sand on the core, that would suggest it was a continued fission reaction and they were trying to absorb the neutrons to stop that reaction, right? Without the moderator present, how could the reaction take place as it did?

If fresh nuclear fuel can be manipulated by hand (I've read refueling happens by hand with special tools), what makes it so dangerously radioactive when the core is exposed?

submitted by /u/AaronPossum
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If vaccines don't fully take effect within 2-3 days of administration, why don't we continue to have physical effects such as fever until the immune system has reached it's goal?

Posted: 17 Dec 2020 08:01 PM PST

I've long heard that certain vaccines don't "take effect" until weeks after administration. My understanding is that the immune system is building immunity during this time. What keeps us from having physical symptoms while this is going on?

submitted by /u/makemeoneplease
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Giving covid vaccine to someone that covid positive?

Posted: 17 Dec 2020 12:24 PM PST

What would happen if you gave the coronavirus vaccine to someone that is positive for coronavirus? Would they get better or the vaccine wouldn't do anything because it's too late?

Edit to title - that's

submitted by /u/Broken_20
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Thursday, December 17, 2020

AskScience AMA Series: We're Cheryl Bowman, Deputy Branch Chief for High Temperature and Smart Alloys, and Sean Clarke, Principal Investigator, X-57 Maxwell Experimental Aircraft. We are part of the NASA team that is developing new technology for Electrified Aircraft. Ask us anything.

AskScience AMA Series: We're Cheryl Bowman, Deputy Branch Chief for High Temperature and Smart Alloys, and Sean Clarke, Principal Investigator, X-57 Maxwell Experimental Aircraft. We are part of the NASA team that is developing new technology for Electrified Aircraft. Ask us anything.


AskScience AMA Series: We're Cheryl Bowman, Deputy Branch Chief for High Temperature and Smart Alloys, and Sean Clarke, Principal Investigator, X-57 Maxwell Experimental Aircraft. We are part of the NASA team that is developing new technology for Electrified Aircraft. Ask us anything.

Posted: 17 Dec 2020 04:00 AM PST

Join us today at 2 p.m. ET (19 UT) to ask anything about NASA's recent technology developments for Electrified Aircraft Propulsion - the use of propulsors (propellers or fans) driven by electric motors to propel or help propel aircraft ranging from air taxis to subsonic transports. From developing technology to aircraft concepts to flight testing, we're working toward a new generation of aircraft with a lower carbon footprint.

  • We built and tested a lithium-ion battery pack that uses Space Station technologies to improve safety and reliability - already being used in other experimental aircraft!
  • We've doubled the temperature capability of soft magnetics for flight electronics.
  • We will soon be flight testing the all-electric X-57 Maxwell Experimental Aircraft in a 2-motor, 150 kW mode followed by a 14-motor, 300 kW flight test on a high-performance wing.
  • We are using what we learn on experimental aircraft and in laboratories to help write the design and test standards for electric propulsion system in future passenger aircraft.
  • We can't wait to answer your questions on how we're turning this idea from science fiction to reality.

Participants include:

  • Cheryl Bowman, Deputy Branch Chief for High Temperature and Smart Alloys
  • Sean Clarke, Principal Investigator, X-57 Maxwell Experimental Aircraft and Advanced Systems Development Engineer

Proof: https://twitter.com/NASAaero/status/1338884365632331779

Username: /u/nasa

submitted by /u/AskScienceModerator
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Does a photon travel more than 1 billion light years in 1 billion years due to the expansion of space?

Posted: 16 Dec 2020 10:41 AM PST

Assuming we shoot a photon out into space, it would go 1 light year after 1 year, and 1 million light years after 1 million years.

Because after that the expansion of space is noticeable, would photon be farther than 1 billion light years after 1 billion years?

Does the expansion of space (Hubble flow) carry the photon forward?

submitted by /u/mobydikc
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If regularly donating blood without being re-exposed to a particular pathogen, will circulating antibody levels decline over time?

Posted: 17 Dec 2020 07:06 AM PST

I'm not an immunologist so please forgive me if there are glaring errors.

My understanding as I remember it from many years ago is that when a previously encountered pathogen is detected by B-memory cells, they proliferate and differentiate into plasma cells, which begin to produce antibodies until the pathogen is cleared. Whilst the B-memory cells will survive, the plasma cells and antibodies in the blood stream will decline over time until the pathogen is reintroduced and more are produced?

I ask this in relation to Covid as I had Covid-19 back in early March and was very sick. However I've just had a negative antibody test when trying to donate plasma. I've donated blood on at least 4 occasions since and have been very careful with distancing etc so would hope I have not come back into contact with any viral particles.

submitted by /u/RichardsonM24
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Is it possible to change skin colour from constant tanning?

Posted: 16 Dec 2020 06:38 PM PST

When I was a kid I had light skin. I tanned easily and always stayed in the sun without sunscreen. Fast forward to being near 20 I have a lot darker skin (brown) although its gotten lighter slowly since I stopped tanning. Is my dark skin a result of staying in the sun for my whole childhood or would it have happened regardless, and will it return to my natural colour, I've just been curious about this for a while.

submitted by /u/Donttgiveup
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Does taking a vitamin D supplement stop natural vitamin D production?

Posted: 16 Dec 2020 10:04 AM PST

If I would for example take 1000 IU of oral vitamin D every day, does my natural vitamin D production in the sun stop due to the supplement taking?

submitted by /u/krafter22
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Given that light travels faster in air than in water, and sound travels faster in water than air. Is there a theoretical (or real) substance where sound travels faster than light?

Posted: 16 Dec 2020 08:59 PM PST

If so, what sort of properties does that substance have? Is it possible to be the density required while still being transparent? (Assuming my not transparent on the visible spectrum, but anywhere else?)

Would a sound wave travelling through it create 'photonic booms'

submitted by /u/nIBLIB
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Does NASA have a plan to save astronauts that are stranded on the ISS?

Posted: 17 Dec 2020 06:39 AM PST

Could NASA save astronauts, or are they just crossing their fingers and hoping that this situation won't happen.

submitted by /u/Puppy_Cat_Meowz2020
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What are the implications of a COVID positive, asymptomatic person donating blood?

Posted: 16 Dec 2020 04:53 PM PST

My understanding is here in the US the Red Cross tests blood donations for COVID antibodies, but do not test the donee for COVID. Obviously, given the amount of asymptomatic COVID carriers I am sure that people who are actively positive have donated. What would this mean for recipients of this blood?

submitted by /u/scoopG
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How do I calculate the celestial coordinates of an object in the solar system at a given time from its ephemerides?

Posted: 17 Dec 2020 12:12 AM PST

More specifically, do I need to account for Earth's axial precession (Precession of the Equinox), and if so, how?

Not a homework question, although it sounds like one. Just something that came up in a discussion.

submitted by /u/TheWalruss
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How does our body know the spike protein made from the mRNA vaccines is foreign?

Posted: 16 Dec 2020 07:27 PM PST

Just what the question says. How does the body know something made by our cells is foreign?

submitted by /u/roweira
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Can Human Beings become immune to the Corona Virus due to evolution?

Posted: 17 Dec 2020 04:22 AM PST

There are a number of diseases that no longer affect us, since we have undergone enough evolution to become immune to it. So, is it possible that the body (given enough time), can develope an immediate immunity even to a virus as deadly as the Corona virus in the future?

submitted by /u/NegativeProtonsLol
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Is there a uniquely "Human" protein, or a unique aspect of a Human protein that exists in humans and no other species?

Posted: 16 Dec 2020 07:42 AM PST

Asking for a television script I'm writing.

Thank you!

submitted by /u/Masterdavy108
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What makes fusion power so hard to keep self-sustaining?

Posted: 17 Dec 2020 03:24 AM PST

I've read up a bit on fusion power plants, and it seems to be some pretty end-game energy production. Though the most recent top efficiency I've seen is 67% energy return.

My question is, if it's capable of producing so much energy how come it takes more than it gives back?

Is it sustaining the reaction for long enough, or does more have to be generated at a time and it's an issue with containment?

submitted by /u/ChunderSmash
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How is electron degeneracy pressure different from thermal/kinetic pressure?

Posted: 16 Dec 2020 09:24 PM PST

How do space vehicles know how to orientate themselves? (Specifically unmanned spacecraft)

Posted: 16 Dec 2020 11:11 AM PST

Do they use a gyroscope system? Or the planets magnetic field?

(I got curious watching a Scott Manley video on YouTube, he talked about the pitch and yaw of the recent 'Astra' rocket launch and I realised I'd never questioned the method - hard to get a straight-forward answer out of google)

submitted by /u/Metaforeman
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How do the vaccine companies prove they have 94/95 percent effectiveness? How can they possibly test this, how do they know the people they injected in the clinical trials just weren't exposed to the disease yet?

Posted: 16 Dec 2020 11:01 PM PST

Ex: how do they know whether the vaccine worked or whether the person's social distancing worked? How can they be sure it was the vaccine doing something?

Basically how they design their experiment to be able prove it was actually the vaccine?

submitted by /u/wallpapersdance
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Is there evidence that suggests whether getting the primary vaccine and the booster shot in the same arm is better/worse/equivalent to getting them in opposite arms?

Posted: 16 Dec 2020 12:29 PM PST

(Vaccines in general, rather than just the Covid vaccine...)

submitted by /u/scottsinct
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How are other common seasonal viruses transmitted?

Posted: 16 Dec 2020 02:48 PM PST

So Covid is transmitted most by air droplets. What about the seasonal flu? Common cold? Stomach flu/Norovirus? Is everything air droplets or are some more apt to live on surfaces for longer?

submitted by /u/Meilikah
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How do COVID19 vaccinations complication rates compare to flu vaccinations complication rates?

Posted: 16 Dec 2020 05:05 AM PST

From the FDA report, roughly twice as many people had fatigue/headaches compared to placebo, and 10 times as many had chills compared to placebo. When I get a flu shot I always feel pretty shitty and get chills the next day or two. I guess I was wondering, "If I already feel very shitty from a flu shot, how much better/worse is this going to be?"/"Will I be able to handle it?"

submitted by /u/hobalongalong
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Can a planet have an elliptical ring system and/or an "offset" orbital point?

Posted: 16 Dec 2020 11:01 AM PST

I am wondering a few things:

  1. Can a planet have an elliptical ring system?
  2. Can the barycenter between a planet and its ring system be outside the planet's axis of rotation?
  3. Can a planet with high obliquity have a ring system? Assuming ~90° obliquity, where would the ring system be in relation to the planet's axis of rotation?

If multiple questions aren't allowed: I apologize and will be satisfied to just have the answer to one of my questions.

submitted by /u/mez1337
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