Why is the hazard/mortality ratio for HbA1c higher for the lowest levels? Is it explained primarily by a significant fraction of the ill population having high RBC turnover? | AskScience Blog

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Sunday, January 23, 2022

Why is the hazard/mortality ratio for HbA1c higher for the lowest levels? Is it explained primarily by a significant fraction of the ill population having high RBC turnover?

Why is the hazard/mortality ratio for HbA1c higher for the lowest levels? Is it explained primarily by a significant fraction of the ill population having high RBC turnover?


Why is the hazard/mortality ratio for HbA1c higher for the lowest levels? Is it explained primarily by a significant fraction of the ill population having high RBC turnover?

Posted: 23 Jan 2022 08:25 AM PST

https://www.youtube.com/watch?v=IKyif09lvMo. Risk of death is higher for 4.3/4.4 relative to 4.8.

(b/c high RBC turnover is an indication of something bad?) And what IS the percent of the population that has high RBC turnover?

Like, if you want to do a full analysis of variance of mortality as a function of HbA1c, you want to form a hierarchical model where you explain how variation of mortality explained by HbA1c is DIFFERENT between both high and low levels of HbA1c AND (through cohort matching) what percent of low HbA1c is due solely to high RBC turnover (high RBC turnover is presumably a bad thing).

[are there hierarchical linear models that compartmentalize variance between high levels and low levels of HbA1c?]

submitted by /u/inquilinekea
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On a neural level, how does a condition like depression cause worse cognition?

Posted: 23 Jan 2022 07:45 AM PST

I keep reading that depression causes decreased executive function, difficulty thinking clearly, etc.

I'm just wondering what is happening when we create thoughts that something like depression can mess that up.

That would mean it has the power to change how someone fundamentally thinks but how? Does it inhibit certain cells from communicating such that a thought that a healthy person has, doesnt occur if the individual is depressed?

submitted by /u/ReadComprehensive920
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With all the covid tests going on are we getting any non-covid related data from the tests?

Posted: 23 Jan 2022 03:54 PM PST

I would imagine all personally identifiable information(PII) would be stripped, but this would be a huge waste of an opportunity to do some other research if we didn't collect the data.

submitted by /u/LtMelon
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Could pregnancy possibly delay menopause?

Posted: 23 Jan 2022 04:00 AM PST

So I have a question that there may not even be an answer to. I doubt there would be any scientific studies on this as there would be too many variables to be able to control the study. But I am curious about what other think.

But let me explain a little better what I mean before answering.

There are a few scientific facts first: 1. When a woman is born she already has all the eggs she will ever have. Women do not produce more so that's it. 2. When a woman is pregnant she (typically) will stop ovulating for the duration of the pregnancy, and may not start again for up to a year after giving birth.

So let's say a woman has 10 healthy to term pregnancies. We can average that out to 18m per pregnancy where she does not ovulate. Over those 10 pregnancies that adds up to 15 years of not ovulating.

So theoretically could that delay her from starting menopause for up to 15 years?

Also please don't come at me over this question. I am being genuine in my curiosity here and just wondering what others opinions might be. And by no means am I planning on having a whole heap of children to try and delay my own menopause. I have 3 children and that is enough for me. This is just a question.

submitted by /u/Top_Replacement_562
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Why do apples start to go bad around their cores?

Posted: 23 Jan 2022 05:54 PM PST

Sometimes when you eat an apple you can see that either its core or around it is of a brownish color (not caused by exposing it, it was already that way when you bit into it or cut it), what causes that? Does ethylene accumulates there? Is that a thriving place for microbiota? If so, why?

submitted by /u/foobaca_
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What are the long term effects of a lactose intolerant person continuously consuming dairy throughout their life?

Posted: 22 Jan 2022 11:49 PM PST

Does it hurt the stomach lining? Does this person grow a tolerance to dairy? Do they die? Does nothing happen? I miss milk.

submitted by /u/theguyfromacrosstheb
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Throughout earth’s history, has the movement of tectonic plates caused the disappearance of any mountains or mountain ranges?

Posted: 23 Jan 2022 02:07 AM PST

When we think about mountain formation, we tend to think about the processes that formed the mountains that exist as we see them today. I've never considered the mountains that may or may not have existed in the past until just a couple minutes ago. In my mind, it would just require a staggering amount of work to form a mountain and then un-form it, but then again the earth has been around for billions of years—plenty of time to get the job done.

submitted by /u/Skating_N_Music_Dude
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What does it mean for a dimension to be "curled up"?

Posted: 23 Jan 2022 02:58 AM PST

Often, in theories purporting the existence of additional dimensions of space, those dimensions are said to be "curled up" in a tiny space. I can imagine there being additional "directions" of space, but I can't understand what it would even mean for a direction (which I assume dimensions are?) to be anything but, well, "straight" or "open". What does it mean for a dimension to be "curled up", compared to it being straight/open?

submitted by /u/Return_of_Hoppetar
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Are microscopes and telescopes the same thing?

Posted: 23 Jan 2022 01:33 PM PST

Like, binoculars for instance. If I look one way it acts like a telescope. But would it double as a microscope looking at it with it flipped?

I was just wondering what the Hubble would see if we inverted it as a microscope instead of a telescope.

Not sure what I'm going for here other than I'm not sure where the end of space is and where the end of zooming into a atom stops.

submitted by /u/CandyOwn7649
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How is vanadium pentoxide produced?

Posted: 23 Jan 2022 07:01 AM PST

I am trying to find the process, but Wikipedia didn't help.

submitted by /u/Noberalon
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In alternating current, how is electricity carried in one direction (from the power source to the electrical device) if the current is constantly changing direction?

Posted: 22 Jan 2022 08:43 PM PST

why does virus infection cause tiredness/exhaustion?

Posted: 23 Jan 2022 10:20 AM PST

when the human body is infected by a virus, what is happening on a cellular level within the body that causes the extreme tiredness/exhaustion??

submitted by /u/idontbelievestuff1
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Has there been a comparison study for nutrition versus seriousness of physical impact of COVID-19?

Posted: 23 Jan 2022 11:14 AM PST

Basically the title; does nutrition have an impact on how sick you get?

Have there been studies and if yes; A) where can I find them? B) is there a simple way of explaining those to the laymen like myself?

submitted by /u/Mr_Boombastick
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Are social chatbot good for human health?

Posted: 23 Jan 2022 07:14 AM PST

In the last months there was a ever encreasing amount of new social chat AIs which are marketed as a way for lonly people to have the social interaction they need. My question is are there any prooven problems with this aplication?

submitted by /u/PXG8Y
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If two streams of gas intersect, does friction occur there? And does that friction produce heat?

Posted: 22 Jan 2022 09:03 PM PST

And if so, is there minimum velocity differential for heat to be produced (for example, does every slight gust of wind generate some negligible heat along its borders at it interacts with air at a different velocity)?

submitted by /u/TonerLegend
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