How does the single human prion protein (PrP) cause a number of different diseases (vCJD, fatal insomnia, kuru, etc) as it changes from PrP(C) to PrP(Sc)? | AskScience Blog

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Friday, July 12, 2019

How does the single human prion protein (PrP) cause a number of different diseases (vCJD, fatal insomnia, kuru, etc) as it changes from PrP(C) to PrP(Sc)?

How does the single human prion protein (PrP) cause a number of different diseases (vCJD, fatal insomnia, kuru, etc) as it changes from PrP(C) to PrP(Sc)?


How does the single human prion protein (PrP) cause a number of different diseases (vCJD, fatal insomnia, kuru, etc) as it changes from PrP(C) to PrP(Sc)?

Posted: 12 Jul 2019 07:02 AM PDT

As far as I can tell, the protein is the same (both in terms of the normal and disease-causing isoforms), and the mechanism is the same (misfolded protein converts normal protein in a chain reaction that leads to protease-resistant plaques). So why are there a number of related but distinct diseases associated with the human/mammalian prion protein?

submitted by /u/akaBrotherNature
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Why does the atmosphere not stratify itself by the molecular mass of its components, with the heaviest gas at the bottom (e.g. CO2, O2, N2...He2, H2) ?

Posted: 11 Jul 2019 11:00 AM PDT

Why does basal cell carcinoma so rarely metastasize?

Posted: 11 Jul 2019 03:07 PM PDT

Biochemically/genetically speaking.

submitted by /u/literaldehyde
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Are we born with our personality, or is it something we develop through experience?

Posted: 12 Jul 2019 01:23 AM PDT

Could we make a rocket that uses both matter and antimatter? Could antimatter be used to propels us in the same way matter does? If it annihilates with matter after it propels something, does that mean it can't be used to propel something in a vacuum?

Posted: 11 Jul 2019 07:25 PM PDT

How do we know if a meteorite came from the outer solar system?

Posted: 12 Jul 2019 06:17 AM PDT

How does the body get rid of dead cells?

Posted: 11 Jul 2019 03:27 PM PDT

My wife started chemotherapy this week. She asked me how the cancer exists the body. I'm a truck driver. I have no idea.

I looked it up as best I could and the closest I could get was reading that the body gets rid of billions of dead cells every day.

I assume that chemo kills cancer cells, then...

Somethings called Axl and Mer target the cells that are dead and summon Ligands.

From there macrophages swoop in and eat the dead cells.

I'm not sure I got all that right. But, if I did, what happens next? How do the macrophages get it to exit the body?

submitted by /u/Digyo
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What factors need to match between two people to be a valid bone marrow donor to a recipient?

Posted: 11 Jul 2019 08:15 PM PDT

If someone were to donate marrow to someone else, is blood type the only factor that needs to be a match (assuming the donor is in all other ways a healthy and qualified donor?) or are there other factors at play that also need to be matched in a case-by-case basis?

submitted by /u/jude802
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Is the belief that a comet triggered the Cretaceous–Paleogene extinction still the most widely held belief?

Posted: 11 Jul 2019 02:49 PM PDT

If so, can someone explain to me how a comet could have triggered such a mass extinction?

submitted by /u/Santarini
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In what ways does the discovery of a thin accretion disk around NGC 3147 change our theories of black hole creation?

Posted: 11 Jul 2019 11:01 PM PDT

Yesterday NASA released a finding about the super massive black hole in NGC 3147. They were studying low magnitude black holes, and found that the accretion disk is both much flatter and closer to the black hole than should be possible based on our ideas of how black holes work.

What, in our theories, is missing and going to need to be changed. One of the blogs I read was stating that this changes how we look at black hole generation, but did not give any details.

Thanks

submitted by /u/igloofu
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Collectively, do North American common starlings have a deficient amount of genetic material?

Posted: 11 Jul 2019 01:07 PM PDT

I understand that all N. American starlings descend from 60 individual birds released in NYC's Central Park in 1890. Did this create a genetic bottleneck for their descendants? If so, has there been any interesting genetic impact? If not, why not - how do 60 individuals possess sufficient genetic material?

submitted by /u/elphin
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Can two photons hit an electron at the exact same time transmitting to it the same energy as it was hit by a single higher frequency photon?

Posted: 11 Jul 2019 11:32 AM PDT

How do perfect pyrite cubes form in the halo of quartz veins?

Posted: 11 Jul 2019 08:02 PM PDT

Veins form as a result of brittle fracturing of the country rock, and typically, silica rich fluids (hydrothermal fluids) rush in to fill the open space. These fluids can eventually form minerals within the vein and along the veins' margin, but how do euhedral pyrite cubes form in the halo of the veins (ie. the country rock)? Hydrothermal fluids should be too low in temperature to heat the country rock to a ductile regime, and the veins formed during brittle fracture.

submitted by /u/sufficing
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Do dyslexic people have the same problems with different writing systems? E.g. if they have problems with Latin script, will they have the same problems with Chinese characters?

Posted: 12 Jul 2019 12:50 AM PDT

Dumb question; does sound radiation exist?

Posted: 11 Jul 2019 07:15 PM PDT

Just had a thought; let's take an analog sound engineer for example with heavy duty audio equipment; for night clubs.

The said sound engineer sits in there work both, have there system set up and playing.

Under those conditions with density of those vibrations and sound waves bouncing around.

Won't this be considered as being cooked in a microwave oven.

Note: I apologize, I have difficulty articulating and explaining what I have in my thoughts. It's like a language barrier without having a rosseta stone to translate.

submitted by /u/ChefTable2
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Why do cellular frequencies have to be significantly higher than WiFi's 2.4Ghz and 5Ghz? Especially when it comes to the new 5g that's rolling out?

Posted: 11 Jul 2019 01:47 PM PDT

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