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Friday, June 26, 2020

How does antibody treatment work with COVID-19?

How does antibody treatment work with COVID-19?


How does antibody treatment work with COVID-19?

Posted: 26 Jun 2020 01:36 AM PDT

My issue is the following: IV administered IgG mixture does seem to work in animal models and in patients. The question really is: does it work on the lung surface? If it does, how? Any papers I have seen suggested that very little IgG reaches the mucosal surface, as the FcnR transport "outside" is not very effective; IgAs use a different mechanism to reach the surface. Yet it seems like IgG based treatments work.

Do they work by limiting the viral replication outside the lung, leaving the lungs "undefended"? Wouldn't this cause serious problems with inflammation in the lungs? The other idea I can think of is that when these are administered, the integrity of the lung tissue is already compromised, so the IgGs can reach the mucosal membrane reasonably well - but this would mean the treatment is not useful as a preventive measure in mild cases when the patient is in a high-risk group.

Since I cannot find any papers discussing the mechanism of IgG therapy within the lungs I thought I would ask here.

submitted by /u/rambo77
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How much deeper could the Grand Canyon get?

Posted: 25 Jun 2020 08:33 PM PDT

Would the Colorado continue to carve it out until it's down to sea level or, if there is one and it's lower, down to an aquifer?

submitted by /u/Sandman1812
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What's the basis of NMR spectroscopy?

Posted: 25 Jun 2020 12:49 PM PDT

I've been doing some reading online and from what I've seen, there are two different explanations of NMR spectroscopy. One implies that the magnetic dipole moments can flip when hit by radio waves, and when they flip back, energy is emitted in the form of electromagnetic radiation. By analysing the emitted waves, we can determine their source, etc. The other explanation is that the sample is hit by a pulse, causing the dipoles to precess, and it is this precession that is used to determine the isotope in question. My question is, which of these explanations is correct? Is one a simplified version of the other? Or are both correct, and are simply different techniques for sample analysis?

submitted by /u/Shneeshnak
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When was it that we discovered that gas giant are, well, made out only of gas?

Posted: 25 Jun 2020 08:48 PM PDT

I'm reading Arthur C. Clarke's "2001: A Space Odyssey" and at some point in the novel they send a probe into Jupiter (Cassini's Grand Finale-style). While it falls into the Jovian atmosphere they seem to be searching for a surface, but I thought that by then (1968), they'd already know there was none to be found (besides the solid metal core, but that they obviously knew the spacecraft couldn't reach so deeply). Either way, they never find a surface—and that wouldn't be the only fantastic prediction made in this book, to be honest.

submitted by /u/BrKo14
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How do we know an asteroid hit earth 66M years ago?

Posted: 25 Jun 2020 10:17 AM PDT

Do we know that it was an astroid that caused the great extinction? Is it just a theory that hasn't been proven? I've looked up some videos and articles about it, but there's not a lot of information about it. There's some evidence about it including composition of certain sedimentary rocks, but so far I've found nothing concrete.

submitted by /u/Farkle_Griffen
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What happens if you send single-frequency laser pulses through a prism?

Posted: 25 Jun 2020 10:54 AM PDT

I just learned about Fourier analysis, and how any wave that has a beginning and an end is composed of multiple different frequencies added together. With respect to light, this means that a pulse of a single frequency of light can be understood as the superposition of many different frequencies. So a theoretical laser beam that is only ever 'on' could exist as a single frequency, but once you start turning the laser on and off it ceases to be a pure sine wave, and the faster you turn it on and off the wider the spectrum of frequencies those pulses are composed of. (I think this is all true but please correct any errors I've made here).
Does that mean that if you sent pulses of single-frequency laser light through a prism, you could diffract out many different frequencies of light from that one laser frequency? Could you get a rainbow from monochromatic green light for instance, if the pulses were short enough?

submitted by /u/raimbows
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Ignoring the biological ramifications, how cold would the Earth be if all the CO2 in the atmosphere disappeared?

Posted: 25 Jun 2020 12:49 PM PDT

What happens in a nuclear reaction which leads to complete change in physical and chemical properties?

Posted: 25 Jun 2020 09:15 AM PDT

example:

17O + n → 14C + α

what leads to complete change in properties of oxygen to carbon?

submitted by /u/bbro__
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Why is it okay to use animal waste as crop fertilisers? Is it simply because pathogens die long before we eat the crops?

Posted: 24 Jun 2020 06:09 PM PDT

I was having a hypothetical discussion with my SO this evening (neither of us has a scientific background). I was asking why it's okay to use animal waste on fertilisers for crops which we then eat, when directly consuming animal feces would be potentially very dangerous (not to mention disgusting).

Is it simply because any pathogens from manure would die long before the crop reaches the supermarket shelf and the consumers' plates? Or is it more complicated than that?

I hope this isn't an extremely dumb question. It's something we both realised we couldn't necessarily answer even after Googling.

Many thanks in advance for any answers!

submitted by /u/Material777
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Thursday, June 25, 2020

Since DNA degrades as we age, would a clone made with an older person's DNA sample have a shorter life expectancy than a clone made with a young person's DNA sample?

Since DNA degrades as we age, would a clone made with an older person's DNA sample have a shorter life expectancy than a clone made with a young person's DNA sample?


Since DNA degrades as we age, would a clone made with an older person's DNA sample have a shorter life expectancy than a clone made with a young person's DNA sample?

Posted: 24 Jun 2020 06:04 PM PDT

Possibly a related question: Why is it that humans are able to produce offspring with "fresh" DNA, yet we are unable to maintain the integrity of our own DNA over time?

submitted by /u/DJ027X
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Do trees die of old age?

Posted: 25 Jun 2020 07:58 AM PDT

How does that work? How do some trees live for thousands of years and not die of old age?

submitted by /u/indigogalaxy_
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why nuclear fission reactions always release neutrons but not protons?

Posted: 25 Jun 2020 04:50 AM PDT

Are moons always smaller than the planets they orbit?

Posted: 25 Jun 2020 02:42 AM PDT

Could there be a planet the size of earth with a moon the size of Jupiter orbiting it? Is it a matter of density or size?

submitted by /u/ah4fukssake
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Could CRISPR be applied as a cure for viruses?

Posted: 25 Jun 2020 04:29 AM PDT

If bacteria uses it as a defence against viruses couldn't humans do it as well? Could it be the long awaited cure for viruses?

submitted by /u/MerpDrp
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How seseriously is Bret Weinstein's Reserve Capacity Hypotheses taken by the scientific community?

Posted: 25 Jun 2020 08:15 AM PDT

In his recent appearance on the Joe Rogan Experience, Bret Weinstein brought up his Reserve Capacity Hypotheses which, roughly said, implies that a particular strain of lab mice that are used for testing pharmaceuticals have been inadvertently bred with abnormally long telomeres. And that this, in practice, leads to unreliable data on toxicity when testing human pharmaceuticals on those mice.

I'd previously read his paper, and it made some sense, and felt that it was at least worth considering, given the implications. But the way that Weinstein spoke on that program set off all of my conspiracy theorists alarms. ...as is tradition with anyone that gets within six feet of Rogan.

So, how credible is his claim and how seriously is it taken by the scientific community?

submitted by /u/ReasoningAloud
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Why have the recent protests across the US not resulted in spikes in coronavirus cases?

Posted: 24 Jun 2020 10:04 AM PDT

Recently COVID-19 cases have been surging upward across the US, especially in the South and West, with the causes being attributed to reopening of the economy, and the Memorial day weekend gatherings. However no major outbreaks have been linked to the massive protests that have occured in cities across the country, despite public health experts warnings about large gatherings of people yelling, chanting, and coughing (from tear gas or pepper spray). How did this happen?

submitted by /u/two-years-glop
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Do we update latitudes and longitudes to account for plate tectonics?

Posted: 24 Jun 2020 01:45 PM PDT

I just watched a documentary about the Yellowstone hotspot, and it said that the US in that region is moving to the SW at about one inch/year. That would be about 1m in 40 years, which is enough to mess up navigation. How do we account for that?

submitted by /u/robertson4379
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Do the memories of people with anterograde amnesia degrade over time?

Posted: 25 Jun 2020 09:04 AM PDT

People with anterograde amnesia are unable to create new memories, so apparently every time they wake up, it's the same day over and over again (essentially). So the last thing they would remember would be the final memories before being afflicted with anterograde amnesia. Do those final memories "age"? As time goes on, do those memories feel more distant? Or does it always feel like they just happened?

submitted by /u/kuuzo
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Is it likely that there are water molecules deep in the ocean that haven't been near the surface since before the Cambrian Period? Or would ocean currents and other similar phenomena make all the water circulate back and forth, given enough time?

Posted: 24 Jun 2020 10:14 PM PDT

This thought popped up as a response to the common saying that humans drink the same water that the dinosaurs once did. As much as there are a bunch of water molecules that do get recycled like this, it begs the question whether some water molecules simply are too deep down and under so high pressure that they never get the chance to emerge and be incorporated into the water system known by land beings.

submitted by /u/fr15287
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What happens to your brain as you're waking up?

Posted: 24 Jun 2020 06:28 PM PDT

When I wake up out of a dream, it takes me about an hour regain my faculties. I'm groggy, thinking is unclear, and I remember random scenes from my dream, which rapidly fade from memory. What's happening to my brain during this period?

submitted by /u/dept_of_samizdat
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What does it physically mean to “observe” a photon in reference to the double slit experiment?

Posted: 24 Jun 2020 06:48 PM PDT

How do we know the magnitude of historical earthquakes?

Posted: 24 Jun 2020 07:15 PM PDT

I'm reading Nate Silver's book The Signal and the Noise and he has a chapter on earthquake forecasting. In it he talks a lot about historical earthquakes, sometimes from centuries ago. For example he talks about a series of 8.1-8.3 magnitude earthquakes that hit the New Madrid Fault over a period of a few months in 1811-1812. How is the magnitude of an earthquake that happened two centuries ago determined?

submitted by /u/qwertyman_101
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Was music theory developed based solely on how the human ear experiences sound? Or does it also based on the natural relationship between sound waves?

Posted: 24 Jun 2020 08:04 PM PDT

Not sure if I used the appropriate tag

submitted by /u/pathemar
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How do archeologists determine the age of artifacts discovered?

Posted: 24 Jun 2020 02:01 PM PDT

What is the method by which our body’s acclimate to taste and smell?

Posted: 24 Jun 2020 03:25 PM PDT

Why do I initially smell my air freshener then it goes away, but if I leave and return I smell it again? Is it that the sensors ability becomes saturated, or does our brain receive all the signals and just filter some out?

submitted by /u/easyleezy
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Why aren’t nasal vaccines more widespread?

Posted: 24 Jun 2020 11:07 AM PDT

How much difference can there be between immunity your body develops due to exposure to a disease vs immunity from getting a vaccine for that disease?

Posted: 24 Jun 2020 07:58 PM PDT

I've heard that the strength of immunity to a disease can vary between the two.

In a recent debate, I've had someone assert that immunity developed from contracting the disease will always be stronger than immunity from getting a vaccine. I was highly skeptical, but didn't have the domain knowledge to argue it, so here I am.

submitted by /u/makriath
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What exactly about hydrogen bonds (between H and N,O,F) makes it so special that it gets its own bond type?

Posted: 24 Jun 2020 05:13 PM PDT

Looking at boiling point graphs, hydrogen bonded substances have a significantly greater B.P than similar molecules with no hydrogen bonding. Furthermore, molecules with an electronegativity difference very close to the limit of hydrogen bonding show very different behaviours.

What is special about it, and why is the distinction from dipole dipole bonding?

submitted by /u/MonotoneChameleon
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Do van der Waals forces include or exclude dipole-dipole forces?

Posted: 24 Jun 2020 11:02 PM PDT

I searched online and found 2 conflicting definitions on numerous websites:

1) Dipole-dipole forces are a type of van der Waals force.

2) van der Waals forces and dipole-dipole forces are separate, with the former only referring to London dispersion forces.

Does anyone know which one is correct?

submitted by /u/zacharyangrk
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What determines gendered voice differences?

Posted: 24 Jun 2020 06:26 PM PDT

Men and women tend to sound different. To what degree is this the result of social conditioning, and conversely, how much of this is dictated by physiology? Also, how consistent are gendered voice differences from culture to culture?

submitted by /u/frogglesmash
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What do the labs actually look at to determine a positive or negative COVID result?

Posted: 24 Jun 2020 04:06 PM PDT

Wednesday, June 24, 2020

A study today showed Covid antibodies drop off quickly (70% in 2-3 months). But don't all antibodies drop off quickly? Isn't this normal?

A study today showed Covid antibodies drop off quickly (70% in 2-3 months). But don't all antibodies drop off quickly? Isn't this normal?


A study today showed Covid antibodies drop off quickly (70% in 2-3 months). But don't all antibodies drop off quickly? Isn't this normal?

Posted: 23 Jun 2020 11:50 AM PDT

I'm linking the article I read from Reuters. I hope this isn't unacceptable. I'm simply curious whether this is a normal effect over time, or is something unique to Covid (if it's known).

https://www.reuters.com/article/us-health-coronavirus-antibody/antibody-levels-in-recovered-covid-19-patients-decline-quickly-research-

submitted by /u/zgrizz
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AskScience AMA Series: We spent a month at an Antarctic research station and all we have to show for it is this 10-part documentary. AUA!

Posted: 24 Jun 2020 04:00 AM PDT

Hi! I'm Caitlin, a producer at PBS' science documentary series NOVA and co-host of Antarctic Extremes. That's our new 10-part YouTube series that takes place in - you guessed it - Antarctica. Adventuring to Antarctica had been a life-long dream of mine. After all, it's the closest I can get to traveling to another planet. No joke, that really was my plan... I went to space camp at least three times as a teenager. We spent 4 weeks on "the ice," based out of McMurdo Station in Oct-Nov 2018, to film and get a taste of the life lead by scientists and other personnel in one of Earth's most extreme environments. (Now you get the series title.) Some of my favorite memories include: getting to boss Arlo around. Learning to ride a snow mobile. Mt. Erebus. The baby seals. Pretending I was on Echo Base. The cookies. OMG, the cookies. Least favorite memory: let's just say my radio call sign was "Can't Sleep." And penguins... seriously overrated.

When I'm not in Antarctica, since abandoning my childhood plans to be an astronaut (for now at least), I take on the more realistic mission of saving the planet as a filmmaker with a focus on environmental science documentaries. I studied Earth and Planetary Science and Media Studies at Harvard University, and then worked on award-winning documentaries for FRONTLINE and NOVA. Some of my climate/environment related production credits include co-producing NOVA's Emmy-nominated 2-hour television special on climate change, Decoding the Weather Machine, and the virtual reality experience Greenland Melting. I am also host of the online interactive science game, Polar Lab.

Hi there, Reddit! My name is Arlo Perez and I'm the co-host and editor of Antarctic Extremes, a 10-part series documenting life and science down in the coldest natural laboratory in the world. As part of the series, I got to film and interview scientists who study seals and build underwater robots. And just to give you a better sense of what it's actually like to live down there, we added a few of our favorite (mis)adventures, like the one time I got to ride an Antarctic "pickle".

A bit about me: I'm originally from a small city in Mexico, and although I grew up with my favorite cartoon being The Wild Thornberrys, I didn't really get to see much of the world until I left my parents' place at the age of 16 and moved to the U.S. After improvising my way through the first-generation immigrant experience, adapting to American culture (y'all need to seriously step up your coffee game), and with a lot of help from friends and family, I managed to get into Boston College majoring in political science and film, work as a film PA for a year, and eventually, start my dream career at NOVA in 2018. Then, through a mixture of persistence and luck, I had the opportunity to go to Antarctica as part of my first big field assignment along with my co-worker/best friend/bossy older sister Caitlin Saks. Yeah, you read that right.

My first assignment was working in one of the harshest environments on Earth. On a tight deadline. With a 3-person crew. Since Caitlin gave hers, my favorite memories include: the 24 hour daylight (primo for us procrastinators). Ice-caves. Realizing that Antarctic scientists love to have karaoke night. Least favorite memory: finding out we left all of our clothes on the helicopter that dropped us off in the remote Dry Valleys...

Proof! We'll be on at 1:00 p.m. ET (17 UT), AUA!

Username: novapbs

submitted by /u/AskScienceModerator
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Ask Anything Wednesday - Physics, Astronomy, Earth and Planetary Science

Posted: 24 Jun 2020 08:09 AM PDT

Welcome to our weekly feature, Ask Anything Wednesday - this week we are focusing on Physics, Astronomy, Earth and Planetary Science

Do you have a question within these topics you weren't sure was worth submitting? Is something a bit too speculative for a typical /r/AskScience post? No question is too big or small for AAW. In this thread you can ask any science-related question! Things like: "What would happen if...", "How will the future...", "If all the rules for 'X' were different...", "Why does my...".

Asking Questions:

Please post your question as a top-level response to this, and our team of panellists will be here to answer and discuss your questions.

The other topic areas will appear in future Ask Anything Wednesdays, so if you have other questions not covered by this weeks theme please either hold on to it until those topics come around, or go and post over in our sister subreddit /r/AskScienceDiscussion , where every day is Ask Anything Wednesday! Off-theme questions in this post will be removed to try and keep the thread a manageable size for both our readers and panellists.

Answering Questions:

Please only answer a posted question if you are an expert in the field. The full guidelines for posting responses in AskScience can be found here. In short, this is a moderated subreddit, and responses which do not meet our quality guidelines will be removed. Remember, peer reviewed sources are always appreciated, and anecdotes are absolutely not appropriate. In general if your answer begins with 'I think', or 'I've heard', then it's not suitable for /r/AskScience.

If you would like to become a member of the AskScience panel, please refer to the information provided here.

Past AskAnythingWednesday posts can be found here.

Ask away!

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Where did all the sand in the Sahara desert come from?

Posted: 23 Jun 2020 06:41 PM PDT

I've heard that around 5 thousand years ago the Sahara desert was a tropical forest, full of life. And then, it turned into the wasteland that we know today. Where did all the sand in the Sahara desert come from?

submitted by /u/maturespaghetti
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Why is France doing so poorly against COVID-19 compared with other countries?

Posted: 23 Jun 2020 11:07 PM PDT

France as of now has a 28% mortality rate. At first I thought it was due to a higher median age, however Italy (once considered the worst country for COVID) has a higher age and only have an 11% death rate.

Can someone explain why France is doing so poorly compared with other countries?

Thank you.

submitted by /u/PhuckinFred
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Is it possible to develop alcohol resistant pathogens?

Posted: 24 Jun 2020 03:30 AM PDT

Along the same lines as antibiotic resistance, if you clean something with alcohol but leave a few bacteria behind, over time is it possible for random mutations to produce alcohol resistant bacteria/virusus/parasites?

submitted by /u/Vantavole
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How do underwater cables deal with tectonic rifting? Is it even an issue?

Posted: 23 Jun 2020 09:47 PM PDT

Can we accurately measure the death toll from COVID by simply comparing the death rate for the last few months to the death rate from previous years? Is that where the 120,000 figure comes from? If not, what are the problems with this approach?

Posted: 24 Jun 2020 12:18 AM PDT

Please forgive me if this is an ignorant question. It is an approach that makes sense to me, but it occurred to me that perhaps there is some problem with this approach that I have not considered.

submitted by /u/Alaska_Jack
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Why isn’t the coronavirus infection and death rate more linear?

Posted: 24 Jun 2020 07:40 AM PDT

It follows a general trend, but it vacillates dramatically day to day.

submitted by /u/StinkinFinger
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Do people who are sunburned easily have more or less a chance to get skin cancer?

Posted: 23 Jun 2020 02:21 PM PDT

Damaged cells are told to die so as not to turn into cancer cells. So, would this not mean that if your skin cells die relatively easy, you would have less of a chance for cancer?

submitted by /u/Foss_Oswell
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What inferences, if any, can be drawn from an unrooted phylogeny?

Posted: 24 Jun 2020 06:51 AM PDT

I know unrooted phylogenies are a useful simplification because each one encapsulates many different rooted trees. But if you look at an unrooted phylogeny itself, with no background knowledge as to where to root it, what can you say about the taxa involved? For example, in the first image here, one might be tempted to say that we can infer that humans are more closely related to chimps than they are to gorillas. But we can't: if the tree's root was actually at point B (hypothetical), then that's false. So is the unrooted tree merely an intermediate step on the ultimate journey, with no insights to be gleaned?

But then how can that be reconciled with their frequent appearances in journals, and the fact that some analytical methods for unrooted phylogenies really do mean to convey information (such as the hypothetical second phylogeny linked here)?

Thank you so much for your help!

https://imgur.com/a/pcQlyGI

submitted by /u/Euarchontoglire_85
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Simple question: Is it true that we can see stars that are technically "behind the Sun" because of the way gravity bends light?

Posted: 23 Jun 2020 12:26 PM PDT

Gonna be real honest here: I've been down on a Bob Lazar rabbit hole, and this is a line he has been repeating for the past 31 years.

I wanna say it sounds like bullshit, but I don't know nearly enough about stars to say that (cue Philadelphia Mac gif here)

The question is simple: Is is at all true that there are stars we technically shouldn't be able to see because they're behind the Sun that we can indeed see because of the way the massive mass of the Sun bends the light emanating from them?

It sounds like possibly the biggest throwaway plothole in his big bullshit story, but I'd still like an actual astronomer to succintly prove whether or not this is wrong.

submitted by /u/DoNotSufferFools
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When a new drug enter clinical trials, how is the total size of the population decided?Is it typically greater then a particular number (say 500) or it changes from one medicine to another?

Posted: 23 Jun 2020 09:36 PM PDT

Are n95 masks effective against slowing the spread of disease?

Posted: 23 Jun 2020 08:08 PM PDT

I've been seeing a lot of people saying they are and a lot of people saying that they aren't or recommending that they shouldn't be used for this purpose. Which is true?

submitted by /u/jesssssssssssssssssi
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Why does sunscreen wear off?

Posted: 23 Jun 2020 03:50 PM PDT

As silly as it sounds, why does sunscreen wear off and need to be reapplied? It doesn't lose efficacy in the bottle, so why does it have such a short lifespan when applied to the body?

submitted by /u/JebamTiSve
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Why are pterosaurs not considered dinosaurs? What are the classification criteria that make up the group dinosaur but exclude pterosaurs? Are there other classical "dinosaurs" that are excluded from the group?

Posted: 23 Jun 2020 11:38 AM PDT

How exactly will an mRNA 2019-nCoV vaccine approach work on the cellular level?

Posted: 23 Jun 2020 06:28 PM PDT

Someone I know told me that an mRNA vaccine for the coronavirus, like Moderna's vaccine, will use mRNA in conjunction with the reverse transcriptase enzyme to incorporate the spike protein code into the host's own DNA genome. I'm all for vaccines that safely and effectively prevent diseases, but I would be hesitant to get a vaccine that alters my genome for the rest of my life. Is this how mRNA vaccines work, or do they instead only temporarily introduce mRNA strands that will eventually dissipate/be broken down?

submitted by /u/Snikerdoodlz
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What is the role of 2'0 methyltransferase in viruses and viral replication?

Posted: 23 Jun 2020 02:40 PM PDT

Could someone explain how this enzyme allows a virus to attach and replicate in Eukaryotic cells?

submitted by /u/Cdaittybitty
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Are there viruses that infect underwater/marine ecosystems?

Posted: 23 Jun 2020 11:35 AM PDT

Are there viruses that infect underwater/marine ecosystems in the same way that COVID-19 (and other virus outbreaks) have infected aboveground ecosystems? If so, can we draw any conclusions about the transmissibility of viruses through the medium of water vs. the medium of air?

submitted by /u/ertww
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Are there any publicly available De-identified Patient Datasets for COVID-19 analysis?

Posted: 23 Jun 2020 07:55 PM PDT

I know Health Catalyst, Inc. and Cerner are making their datasets available, but only to a select number of people and certainly not to me for my own personal analysis. However, I'm wondering if anyone else has looked into this question and perhaps even had some success.

*I know there are tons of publications out there already regarding COVID-19, but just like all the engineering publications I read, they have good/interesting/unique information, just not specifically what I'm looking for.

submitted by /u/Curiou
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Why does calcium interfere in the absorption of some antibiotics?

Posted: 23 Jun 2020 11:53 AM PDT

Does toothpaste break SARS-CoV2, similar to how soap does?

Posted: 23 Jun 2020 07:07 PM PDT