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Thursday, February 4, 2021

AskScience AMA Series: Updates on COVID vaccines. AUA!

AskScience AMA Series: Updates on COVID vaccines. AUA!


AskScience AMA Series: Updates on COVID vaccines. AUA!

Posted: 04 Feb 2021 06:00 AM PST

Millions of people have now been vaccinated against SARS-COV-2 and new vaccine candidates are being approved by countries around the world. Yet infection numbers and deaths continue rising worldwide, and new strains of the virus are emerging. With barely a year's worth of clinical data on protections offered by the current batch of vaccines, numerous questions remain as to just how effective these different vaccines will be in ending this pandemic.

Join us today at 2 PM ET for a discussion with vaccine and immunology experts, organized by the American Society for Microbiology (ASM). We'll answer questions on how the current COVID vaccines work (and what the differences are between the different vaccines), what sort of protection the vaccine(s) offer against current, emerging and future strains of the virus, and how the various vaccine platforms used to develop the COVID vaccines can be used to fight against future diseases. Ask us anything!

With us today are:

Links:

submitted by /u/AskScienceModerator
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What kind of material are those sticky hand toys made of and why is it able to be washed and continued to be tacky?

Posted: 03 Feb 2021 08:11 AM PST

Always wondered about the specific rubber or plastic used.

submitted by /u/xDisturbed0nex
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How do antibodies attack coronavirus in the upper respiratory system?

Posted: 04 Feb 2021 05:28 AM PST

Every simple explanation I've ever heard about how antibodies work, describes an example where the virus is "floating around in fluid" like either blood or some other kind of fluid, and the antibodies float around too and "stick" to the antigens and neutralize the virus.

But from my understanding, SARS-CoV-2 attack vector is the upper respiratory system, where it enters our body from floating droplets in our airways through the nose and mouth. The droplets then settle on the tissue inside of our airways and the infection begins there. Is my visualization of how that works correct?

If such is the case, the virus is initially hitting "exterior" cells, because it is touching the cells that line your airway, so they are hitting a "wall" of cells in your nose and throat and beyond that wall is just a cavity filled with air.

So how do the antibodies neutralize the virus in this situation? If the virus is not "inside" our body floating around in our blood stream.

I'm curious to know the mechanics of this or if I'm just totally wrong about how all of this works.

Thanks!

submitted by /u/thosewhocannetworkd
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Why is so much of the American West dominated by coniferous forests?

Posted: 03 Feb 2021 04:41 PM PST

It seems like the West has a much higher proportion of conifers than forests east of the Great Plains do. Is this only because of generally higher levels of elevation and aridity?

submitted by /u/Bem-ti-vi
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Where in the US does the most weathering occur?

Posted: 03 Feb 2021 06:50 PM PST

I read that the most weathering occurs in warm wet environments so does that mean the most weathering is in Florida? I assumed it would be somewhere with mountains.

submitted by /u/Aleatorytanowls
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Do viruses change every time they split?

Posted: 04 Feb 2021 07:06 AM PST

Why do other planets consist of very few elements (<10) while Earth has ~100 elements found in nature, with many compounds?

Posted: 04 Feb 2021 06:32 AM PST

Does Photon Redshift (and blueshift) violate conservation of Energy?

Posted: 03 Feb 2021 12:27 PM PST

So, according to the laws of physics, energy cannot be created or destroyed, meaning the amount of energy stays constant, however, Photon redshift has the photon losing energy, but wouldn't that violate energy conservation? Because what exactly would the photon be losing energy to? If there's nothing for the energy to be transfered to, the only way for the photon to lose energy would be to destroy energy, which according to the laws of physics, isn't allowed, but since the photon is losing energy and it's not being transfer, is energy being destroyed as the photon redshifts?

submitted by /u/Birds_106
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How do muscles store Glucose ?

Posted: 03 Feb 2021 01:14 PM PST

So as we studied, the liver regulates the amount of glucose in the blood , if the blood has 2.5g/l of glucose before entering the liver it'll come out with 1g/l , so how do muscles store glucose too? I mean, i understand they need it but if it's regulated when it comes out of the liver how can they store more of it. Please excuse me as English isn't my first language so i couldn't explain well my inquiry. Nevertheless, i hope you underatand and am awaiting your answer . Thank you.

submitted by /u/Yan_iel
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Wednesday, February 3, 2021

How does North Korea's handling of COVID-19 affect the development and eradication of the pandemic? Will vaccines be available there?

How does North Korea's handling of COVID-19 affect the development and eradication of the pandemic? Will vaccines be available there?


How does North Korea's handling of COVID-19 affect the development and eradication of the pandemic? Will vaccines be available there?

Posted: 02 Feb 2021 04:17 PM PST

Why does Covid have neurological effects on the brain/sense of smell?

Posted: 03 Feb 2021 07:52 AM PST

So about a week after the worst covid symptoms were over but I still didn't have my sense of smell back, I started noticing that when I wake up in the mornings I am overwhelmed by a smell that basically is like if someone puked and then died right next to me. It's super strong for about 5 minutes and then it goes away and my sense of smell remains completely gone for the rest of the day.

Any idea what causes this and how covid affects the brain in this way?

submitted by /u/TargaryenTV
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Does the existence of mental disease common across humans imply that our thought processes are also common?

Posted: 03 Feb 2021 07:18 AM PST

Suppose we take some viral disease. It affects all humans in the same way, because we have a common biology (i suppose). Can we say the same thing about mental diseases? I understand that we all have the same brain chemistry, so some mental illnesses can be due to altered composition of these chemicals in the brain. But then tablets/medication alone must be sufficient to treat all mental illnesses. But that that is not true, as psychotherapy plays a major role in treating them. So there is a component of these illnesses which is not due to biochemistry, but is 'mental'. So, then does it mean that there is some common 'structure' in our mental thought processes (across humans), similar to there being structure in our biological processes?

To extrapolate it a bit, is there a common "code" that we execute in our mind, similar to there being a code (genetics/epi-genetics) that the body executes?

submitted by /u/nervous-lost-soul
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There's been a lot of speculation about whether people who have received the Covid-19 vaccine may still spread the virus to others. Is this common for other vaccines?

Posted: 02 Feb 2021 11:43 PM PST

I understand that everyone wants to be careful about over promising what the vaccines may do for us until the data is in, but I was wondering whether this is just erring on the side of caution of if there's a history of vaccines for other diseases protecting the recipient from getting sick but not preventing them from spreading it to others.

Edit: since the question may not be crystal clear:

Is it common that recipients of vaccines for other diseases than Covid are protected against getting sick while still being able to spread the disease to others?

submitted by /u/g2petter
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How do adoption & nurture in general affect Own-race Bias for Facial Recognition?

Posted: 03 Feb 2021 07:41 AM PST

When trying to recognize an unfamiliar face, for example when picking someone out of a line up, people tend to be more accurate when the person is of the same race. I would hypothesize that this bias would change if the person doing the picking grew up with parents of a different race. EG, if an ethnically Chinese man was raised from birth by white parents, then that man would be more accurate when recognizing white faces and less accurate when recognizing Chinese faces than a Chinese man raised by Chinese parents. Is there any evidence for or against that hypothesis?

submitted by /u/seefreepio
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Ask Anything Wednesday - Physics, Astronomy, Earth and Planetary Science

Posted: 03 Feb 2021 07:00 AM PST

Welcome to our weekly feature, Ask Anything Wednesday - this week we are focusing on Physics, Astronomy, Earth and Planetary Science

Do you have a question within these topics you weren't sure was worth submitting? Is something a bit too speculative for a typical /r/AskScience post? No question is too big or small for AAW. In this thread you can ask any science-related question! Things like: "What would happen if...", "How will the future...", "If all the rules for 'X' were different...", "Why does my...".

Asking Questions:

Please post your question as a top-level response to this, and our team of panellists will be here to answer and discuss your questions. The other topic areas will appear in future Ask Anything Wednesdays, so if you have other questions not covered by this weeks theme please either hold on to it until those topics come around, or go and post over in our sister subreddit /r/AskScienceDiscussion , where every day is Ask Anything Wednesday! Off-theme questions in this post will be removed to try and keep the thread a manageable size for both our readers and panellists.

Answering Questions:

Please only answer a posted question if you are an expert in the field. The full guidelines for posting responses in AskScience can be found here. In short, this is a moderated subreddit, and responses which do not meet our quality guidelines will be removed. Remember, peer reviewed sources are always appreciated, and anecdotes are absolutely not appropriate. In general if your answer begins with 'I think', or 'I've heard', then it's not suitable for /r/AskScience.

If you would like to become a member of the AskScience panel, please refer to the information provided here.

Past AskAnythingWednesday posts can be found here. Ask away!

submitted by /u/AutoModerator
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When we go hoarse, what makes our voice change?

Posted: 03 Feb 2021 07:00 AM PST

I just woke up hoarse this morning, and it got me thinking about the how's and why's of hoarseness.

submitted by /u/jelliefish_
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What determines if a leaf can be eaten as green vegetable, such as in salads?

Posted: 02 Feb 2021 07:32 PM PST

How new is the science used to make covid vaccines, could they have been made 5, 10 or 20 years ago?

Posted: 02 Feb 2021 03:34 PM PST

Why does spike protein move to the outside of the cell membrane and how does it fold consistently?

Posted: 02 Feb 2021 07:19 PM PST

I'm a little bit fuzzy on the following details on the SARS-COV-2 spike protein:

  • Ribosomes read mRNA and create the amino acid chain of the spike protein.

  • How does the amino acid fold into the exact conformation of the spike protein as found on wild SARS-COV-2? Can't the amino acid chain fold in any number of possible ways? I thought that how you get an amino acid chain to fold a certain way (rather than another) was one of the fundamental challenges in understanding protein folding.

  • Now that the finished spike protein is floating around in the cytoplasm of the cell, why and how does it migrate to the outside of the cell membrane? Why doesn't it just stay inside the cytoplasm? Are there cellular mechanisms in place that identify the protein as something the cell can't use, and in doing so, transport molecules bring the protein to the outside of the cell membrane... rather than destroying the protein while it's in the cytoplasm?

  • Why does the spike protein then imbed itself into the outside of the membrane, rather than be ejected outwards into intercellular space? Or do both things happen - some spikes lodge themselves to the outside membrane while some get released into intercellular space? Immune cells then identify and engulf the naked spike proteins floating around and also the healthy cells with spike embedded on their membranes?

submitted by /u/rabidsoggymoose
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Why is purifying uranium so hard?

Posted: 02 Feb 2021 07:53 AM PST

Countries need to spend millions or billions of dollars on centrifuges to get weapons-grade uranium. Since uranium is so heavy, shouldn't it separate out from other elements fairly quickly? (not that I'm complaining, of course)

submitted by /u/ideastaster
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If there is one queen bee or queen ant in a colony that is responsible for laying all of the larvae, is the whole colony genetically identical?

Posted: 02 Feb 2021 08:05 PM PST

If a queen bee/ant lays all the eggs/larvae in her hive, does that mean the offspring are all genetically identical? Where does she get the sperm? How are the eggs fertilized?

Assuming they are all genetically identical, does this lower their probability of surviving a virus or something similar because they aren't genetically varied?

submitted by /u/whlavisp
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Why do MRI machines use helium specifically and not another gas that's more available?

Posted: 03 Feb 2021 03:26 AM PST

Does the Earth’s rotation effect mantle dynamics or plate tectonics?

Posted: 02 Feb 2021 11:53 AM PST

Would the Coriolis effect due to Earth's rotation impart any lateral rotation of mantle plumes or have any effect on plate movement or interaction at the surface?

submitted by /u/psclafani
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What evidence do we have that asymptomatic spread is significant with COVID?

Posted: 02 Feb 2021 04:08 PM PST

This is an honest question. Most searching I've done seems to indicate that we don't have much evidence. Articles citing evidence tend to just link to articles making claims, and the few studies I've found cite computer models, which I don't take as evidence. Evidence would consist of measuring the frequency with which COVID spreads from asymptomatic people who are followed up with later to make sure they never developed symptoms. Do these studies exist? How were they conducted? What have they shown? If they don't exist, why do we assume this is a major driver?

submitted by /u/Quartersharp
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Why does using millimeter waves in 5G result in faster internet?

Posted: 02 Feb 2021 02:13 PM PST

Reading this: https://www.alibabacloud.com/blog/understanding-how-millimeter-waves-power-the-5g-network_593839

It says:

Based on communication principles, the maximum signal bandwidth in wireless communication is about 5% of the carrier frequency. Therefore, the higher the carrier frequency, the greater the signal bandwidth. That's why, among the millimeter-wave frequencies, 28 GHz and 60 GHz are the most promising frequencies for 5G. The 28 GHz band can provide an available spectrum bandwidth of up to 1 GHz, while each channel in the 60 GHz band can provide an available signal bandwidth of 2 GHz (a total available spectrum of 9 GHz divided between four channels).

I'm assuming this is in the context of frequency modulation.

But I'm confused about the link between signal bandwidth and better speed or lower latency. Reading Wikipedia, signal bandwidth is defined as the difference between highest and lowest frequency. Why is having this being higher an advantage?

Additional question: why is the signal bandwidth 5% of the carrier frequency? I couldn't find any information about that

submitted by /u/vore_your_parents
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What happens to acceleration of a rocket the instant the motor is switched off?

Posted: 02 Feb 2021 02:58 PM PST

So I was watching the SpaceX test flight today and when the rocket hit 10km in altitude it looked like they reduced the throttle so the ship was 'hanging' at v=0 before starting the acceleration downwards.

What would happen to acceleration (and velocity) if the rocket motor was instantly switched off while at full throttle? Would velocity continue to increase for a while or would that instant the motor is switched off be the maximum?

submitted by /u/PotatoBreds
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Does the Sputnik V vaccine encode a stabilized prefusion spike protein, or does it encode an unmodified spike protein?

Posted: 02 Feb 2021 08:30 AM PST

References are welcome.

submitted by /u/In_der_Tat
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When we see headlines saying a particular vaccine is x% effective against COVID-19 - what does that actually mean?

Posted: 02 Feb 2021 09:04 AM PST

I have a fairly good understanding of science and research but I assume the approach my brain thought of (you have two groups of people, one group vaccinated and a control group not vaccinated, and then expose them to the virus and see how many become ill in the vaccinated group compared to the control group) is way too naive for multiple reasons (safety, health, ethics etc etc) - so how have they come to the conclusions that fuel these headline percentages?

submitted by /u/WelshBluebird1
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What is an actual realistic timeline of population displacement and disruption of farming zones due to global warming?

Posted: 02 Feb 2021 05:39 AM PST

I mean pretty much the title. There's some pretty heavy doom and gloomers out there, but like what's the real time frame do you think and what's the real scale of displacement?

submitted by /u/-One_Punch_Man-
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How do we know the half life of xenon-124 is 18 sextillion years?

Posted: 02 Feb 2021 03:37 AM PST

I read that dark matter detectors observed the radioactive decay of a xenon-124 atom, said to be one of the rarest events ever recorded. That's because it's half life is 18,000,000,000,000,000,000,000 years. This changed the current estimated half life, which was 160 trillion years.

How was the previous estimate determined, and how do we know that its half life is now 18x1021 when it's only been observed once and is significantly greater than the age of the universe?

submitted by /u/platonic-solid
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Tuesday, February 2, 2021

When tissue is grafted, how do the blood vessels in the graft find and connect to the blood vessels in the graft site?

When tissue is grafted, how do the blood vessels in the graft find and connect to the blood vessels in the graft site?


When tissue is grafted, how do the blood vessels in the graft find and connect to the blood vessels in the graft site?

Posted: 01 Feb 2021 10:05 PM PST

I recently got a gum graft where connective tissue from the roof of my mouth was grafted into the gums on my lower teeth. How did my graft get "plugged back into" the blood supply? How long would it have taken for the capillaries to have connected, and what is the specific mechanism by which them lil' blood pipes found each other?

submitted by /u/shadowplumber
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Will corona prevention measures have a lasting impact on generic influenza / flu?

Posted: 02 Feb 2021 01:50 AM PST

So, most of the world is following social distancing, heavy lockdowns, mask wearing and washing hands, and influenza has all but been eradicated by now as a result.

Assuming that the lockdown and preventive measures will end some time in 2022 (I'm not too optimistic with vaccination plans), people won't have caught the various influenza / flu strains at all for two years in a row.

Are there even enough "reservoir hosts" in which the strains could have lived on for these two years? And will the human bodies react more intense on strains that would have been "harmless" in 2018, simply because they haven't had to fight against flu for two years?

submitted by /u/mschuster91
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Why don't ripples in a pond propogate at the speed of sound?

Posted: 02 Feb 2021 06:22 AM PST

The title says it all.

Pressure waves in air propogate in all directions at about 340 m/s. Sound travels faster in water, why dont dont we see evidence of this when we throw a rock into a pond?

submitted by /u/ManlyMcBuff
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Why does fish smell fishy?

Posted: 01 Feb 2021 10:30 AM PST

How can colors be inverted?

Posted: 01 Feb 2021 07:32 PM PST

Was thinking about this the other day: the visible color of something is dependant upon what wavelength of light it is emitting, so how can colors be "inverted"? (ie red is the inverse of blue, yellow is the inverse of purple etc) I was thinking of the spectrum of light like a number line, and felt like it didn't make sense. It would be like saying arbitrarily that 4 was the inverse of 6. I understand white being inverse of black; white being all colors, black being the absence of color. Also, never understood in electronics class how if you swapped the polarity of certain LEDs they'd change from red to green.

submitted by /u/DrBobvious
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COVID and Head Lice reduction?

Posted: 01 Feb 2021 11:24 AM PST

With people social distancing and schools being virtual I guess that the number of cases of head lice has been reduced. Could head lice be eradicated by people distancing from COVID's effects?

submitted by /u/bephens
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How is genetic distance measured?

Posted: 01 Feb 2021 11:20 AM PST

i.e. Like when biologists say that humans share whatever % of our genome with chimpanzees or whatever, Does it literally go through every base pair and take the number of differences divided by the overall length or is there some other method?

submitted by /u/shosuroyokaze
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What makes a metal or plastic foil crackle when it is bent or crumpled?

Posted: 01 Feb 2021 12:14 PM PST

What exactly produces these sounds?

submitted by /u/Walambo
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How are satellites electronically grounded?

Posted: 01 Feb 2021 07:15 AM PST

My understanding of regular electronics is that the Earth is used as a charge "sink" so that any circuit can be grounded, with that node acting as a reference O volt point.

On a satellite however, what acts are the charge sink? There presumably needs to be a common ground location for the on board electrics to work correctly.

Is the charge somehow distributed into space Otherwise, is it possible for the spacecraft to constantly build up charge? I feel like this would introduce complications for the many sensitive electronic components on board.

submitted by /u/Player_Found
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PCR tests are both dye and probe based. With dye thats added that binds to double-strand DNA. How does dye know which bit of double stranded DNA to bind to?

Posted: 01 Feb 2021 07:52 AM PST

It's my understanding that the presence of this dye when amplified results in a positive as the dye bound to the ie. Covid 19

Are they testing for the presence of the virus, or the presence of the dye? I've read that probe PCR is more accurate. Could dye bind to other double stranded DNA in the sample?

submitted by /u/prayingfordebbie
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What is the plan for extracting energy for nuclear fusion?

Posted: 01 Feb 2021 10:35 AM PST

With some of the recent breakthroughs in sustained fusion, specifically the recent one that was able to go for about 20 seconds, I was wondering about how it will be useful to humanity. How will energy be extracted from the process? Will it be indirect energy transfer like nuclear fission where the reactors heat water to turn turbines? Photovoltaic cells surrounding the reactor? Something else? Right now it seems that the language is so focused on if we can do it that it doesn't mention how it will be useful.

submitted by /u/physicist314
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Why haven't vaccine gummies been made?

Posted: 01 Feb 2021 11:59 PM PST

Monday, February 1, 2021

If you dug a hole straight down to the other side of the earth, what would happen if you dropped something through it?

If you dug a hole straight down to the other side of the earth, what would happen if you dropped something through it?


If you dug a hole straight down to the other side of the earth, what would happen if you dropped something through it?

Posted: 01 Feb 2021 03:44 AM PST

This is pretending there's no core or anything of that matter that would effect it. How would gravity effect it? What would happen? Would it get stuck in the middle, would it gain enough velocity to shoot out the other side?

submitted by /u/Tight-Start1795
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How do we know if sound cames from behind or from front?

Posted: 01 Feb 2021 04:32 AM PST

We have two ears, so sound going from left or right is slightly delayed in one ear. I believe this is how we can recognize if sound comes from right or left side. But how can one say if sound comes from front or behind?

submitted by /u/uniqiq
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What gives a steel cable so much more tensile strength than a steel rod?

Posted: 31 Jan 2021 09:31 AM PST

How did people find out about the Earth’s core and if other planets have a core?

Posted: 31 Jan 2021 01:23 PM PST

I'm just wondering because the Earth's core is really deep down that nobody can get to it so I'm wondering how people found out there's a core. Also I know some planets have one and other planets don't but how did scientists find out about them? Also what would happen if the Earth's core somehow got put out? I'm just really curious about it and it was a topic my friends were talking about and it was interesting! I'd love any answers/explanations thank you! 💕

submitted by /u/Virgo_moons
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Is the extra 1 mg in a dose of aspirin really necessary?

Posted: 01 Feb 2021 02:39 AM PST

I'm an EMT. Part of our protocol for chest pain is 324mg baby aspirin PO, which is broken down into four 81 mg tablets.

Does that extra milligram make a substantial difference? Why not just make it an even 80/320 mg? I've asked my paramedic partner, who has thirty years experience, and he couldn't really tell me anything, and neither could google. This is something I've been wondering for a while now. TYIA

submitted by /u/white_mage_dot_exe
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How did Avogadro find his number/constant?

Posted: 31 Jan 2021 10:15 PM PST

It greatly baffles me. Also how does that number apply to all atoms/ions/molecules? Or does it even?

submitted by /u/candyflora
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Why are Covid tests least accurate when you’re most contagious?

Posted: 31 Jan 2021 11:28 AM PST

According to Harvard Health, "the rate of false negatives... varies depending on how long infection has been present: in one study, the false-negative rate was 20% when testing was performed five days after symptoms began, but much higher (up to 100%) earlier in infection" (source 1). So molecular tests are least effective when you first show symptoms, however other studies find people are most contagious during the first five days. "A study published yesterday in The Lancet Microbe shows that COVID-19 is most contagious in the first 5 days after symptom onset" (Source 2). How is this possible? Source 1: https://www.health.harvard.edu/blog/which-test-is-best-for-covid-19-2020081020734 Source 2: https://www.cidrap.umn.edu/news-perspective/2020/11/covid-19-most-contagious-first-5-days-illness-study-finds

submitted by /u/jonas4sberg
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How does the asymptomatic rate of coronavirus compare to other illnesses?

Posted: 31 Jan 2021 04:24 PM PST

How does the asymptomatic rate of coronavirus compare to other illnesses ?

submitted by /u/Sheepherder_Nearby
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Do Microbiologists build immunity to laboratory organisms?

Posted: 31 Jan 2021 02:24 PM PST

Do microbiologists that work in close proximity to harmful organisms build immunity to them?

submitted by /u/OptimisticLosers
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How is the time energy uncertainty principal related to calculating energies?

Posted: 31 Jan 2021 10:29 PM PST

Say a particle is "created" somehow. Does that mean that the time energy uncertainty principle states that the variance in E decreases? Also, does that mean that if this created particle is put into an infinite square well that it will not have definite energy in a particular eigenstate, but that the variance of the energy will tend to zero as time goes on?

submitted by /u/CheekyCheetah1
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How concerned should we be about potential ADE with future mutations of SARS-CoV-2?

Posted: 31 Jan 2021 09:20 AM PST

Should we be concerned that future mutations might completely evade the current vaccines, or worse that antibodies from vaccines (or natural infection) might trigger antibody-dependent enhancement with future variants?

Should we be concerned that vaccines and antibody treatments might actually pressure the virus to evolve that way?

There is some suspicion that the UK variant was "brewed" in a patient who received antibody treatment (virological.org link below)

https://virological.org/.../preliminary-genomic.../563

https://www.nature.com/articles/d41586-021-00149-1

https://www.biorxiv.org/.../10.1101/2020.12.18.423358v1.full

https://www.medrxiv.org/.../2020.10.08.20209114v1.full-text

submitted by /u/daviddem
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Before the discovery of surgery to sepaetae them, how did conjoined twins coexist?

Posted: 30 Jan 2021 09:46 PM PST