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Monday, July 6, 2020

How do mRNA vaccines work?

How do mRNA vaccines work?


How do mRNA vaccines work?

Posted: 06 Jul 2020 02:48 AM PDT

AskScience AMA Series: We are Craig, Adam and Kevin. We are the editors of the new book Video Games, Crime and Next-Gen Deviance. The book highlights the inadequacies of social sciences ability to conceptualise deviancy in video games due to the fixation on links to violence. Ask us anything!

Posted: 06 Jul 2020 04:00 AM PDT

We are Criminologists from Birmingham City University and editors on the new book Video Games, Crime and Next-Gen Deviance: Reorienting the Debate. After a drunken debate about the myopic view of video games causing violence after the tragic incident at Sandy Hook we decided to write a book. We argue that such discussion are reductive, inconclusive and frankly boring. We and our fantastic contributors then highlight some key areas in which we can recognise deviancy embedded within video games! The book is open access so free to download electronically and available here: https://www.amazon.com/Video-Games-Crime-Next-Gen-Deviance-ebook/dp/B087BV7H9V

We will be on from 1pm ET (5pm GMT), ask us anything!

Username: nextgendeviance

submitted by /u/AskScienceModerator
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Why is it with viruses you often cease to be contagious well before your symptoms go away?

Posted: 05 Jul 2020 11:45 PM PDT

How do Sperm Whales find Giant squid?

Posted: 05 Jul 2020 10:27 AM PDT

They dive to extreme depths to find the squid but how do they actually locate them? Do they use sonar or smell or some other sense to hone in on them? I imagine its pitch black down there and the ocean is huge so it blows my mind they are able to survive off such a strange and hard to get to diet.

submitted by /u/hornwalker
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Why don't people with heart valves, titanium hips, breast implants etc need anti-rejection meds?

Posted: 06 Jul 2020 06:31 AM PDT

I already feel like this is going to end up being a stupid question, but if your immune system rejects foreign objects in your body, why doesn't it reject those kinds of things like it does organ transplants and, at times, things like piercings or catheters? Thanks so much!

submitted by /u/EnergeticExpert
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What is the significance of community transmission of a disease during a pandemic?

Posted: 05 Jul 2020 11:48 PM PDT

Why is it such a big thing? What are the implications of community transmission stage in an area during a pandemic? Can lack of human resource required to properly track the source of infection of each infected person lead to this stage?

submitted by /u/sparkzz27
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How are multiple signals passed over wires (phone lines, fiber optics, etc...) without interference?

Posted: 05 Jul 2020 03:48 PM PDT

I was thinking about the old days especially when most communication was over the phone lines which I know to be multiple individual strands of wire spanning thousands of miles with various interconnections. But, if my neighbor and I are making a phone call at the same time, how do the lines keep those 2 signals entirely separate when its on the same line for at least a part of the transmission?

submitted by /u/2011StlCards
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Viruses come from animals but where did that animals disease that adapted to us come from?

Posted: 05 Jul 2020 10:51 PM PDT

I read some previous threads that all say that viruses come from animals and "hop on over" to humans but where does the first version of that virus come from? If I'm not mistaken, human viruses are usually mutations of animal viruses. Well where did the animal viruses come from? Other animals? Where did those animal viruses come from? Could we get viruses from eating animals with "broken" cells like cancer cells which then use their cell mutations to become a new virus?

I'm not a biologist, I hope I didn't say something weird.

submitted by /u/FactoryBuilder
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What's the difference between a sorocarp, sporocarp and sporangium (in fungi, specifically Myxomycetes)?

Posted: 06 Jul 2020 04:24 AM PDT

Does everyone have cancerous cells?

Posted: 06 Jul 2020 12:12 AM PDT

I think I read it or heard it once that people have it dormant in their system and something "triggers" it to become active.

submitted by /u/Sofa_King_Nerrdy
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When light is talked about being a wave, how is a wave of probability vs an electromagnetic wave reconciled?

Posted: 05 Jul 2020 11:33 PM PDT

Light is an electromagnetic wave where the magnetic field creates an electric field and so on, to create a wave of light that is self propagating without the need for any medium.

When talking about young's double slit experiment, it is proved light has wave properties due to the interference pattern since light photons are actually waves of probabilities (places the photon has a probability at landing).

So the confusing part is reconciling these two ideas of waves. I can visualize a wave that is created from all the potential locations of a photon (and an interference pattern from this). But then instead of a wave of potentials, we can start talking about the EM wave.

I guess I am just confused. Are these two concepts the same wave? And what is the proper explanation?

submitted by /u/Mets_CS11
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Why do some countries not see a resurgence of covid cases despite re opening everything and acting like there's no more virus?

Posted: 05 Jul 2020 08:56 PM PDT

Okay so I'm French Lebanese and currently live in Lebanon while part of my family live in France. Initially France was hard hit, and quarantined for roughly 2 months and half. They re opened and the population acts like there's no virus since mid may, yet there's no crazy increase in cases or deaths.

Same situation in Lebanon, we quarantined very very early, for 3 months. Apart from the airport that just reopened, we've been de quarantined since the beginning of June and everyone is acting like there's no virus (nightclubs, pubs...) yet we have little cases every day and no increase in deaths.

I don't understand how come it's not rising exponentially again. Or is it a respite until fall?

submitted by /u/MisterDucky92
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How big of a concern are mosquitos and the transmission of COVID-19? Are mosquitos expected to be a big part of the transmission as summer really draws into full effect and people are outside more? Or is there no real data to assume they can deliver the virus from host-to-host?

Posted: 05 Jul 2020 06:48 PM PDT

How deadly would an infectious disease have to be before scientists would consider making an experimental vaccine available?

Posted: 05 Jul 2020 10:23 PM PDT

For purposes of the question, assume the following about the vaccine:

Phase 2 trials have shown safety and efficacy across all age groups among the trial participants

The vaccine is RNA based

There's been some discussion about challenge trials for a COVID-19 vaccine, but practically no discussion of widespread early access in western nations, though the Chinese military has already started inoculating its troops with a Chinese RNA-based candidate.

I understand that administering a treatment to a healthy population is riskier than administering a treatment to a sick population. However, I'm sure I don't need to mention in this community that COVID-19 death tolls are almost certainly higher than reported, that people will die due to untreated chronic conditions, and that the economic effects of the pandemic will reverberate for generations. And that's all on top of a baseline of a disease that is exceptionally virulent and deadly, that America clearly lacks the sustained willpower to rein in through distancing measures, and that has yet to take its toll on many parts of the world. Taking even some carriers out of the population would save lives.

With RNA-based vaccines being safer than historical methods of inoculation and phase 1/2 trials showing promising results,it seems that there are greater questions about efficacy than there are about safety. If the concerns are about efficacy, then the risk of making an unproven vaccine widely available might be giving ammunition to anti-vaxxers. But this risk can be mitigated by being transparent with the public that the vaccine has not been shown to be efficacious, and making people sign waivers consenting and understanding to what they are taking.

Is there something that I'm missing in the risk profile of an RNA-based vaccine, or is the unwillingness of the FDA/biotech/medical community to take risks even in the face of mass death a reflection of an obsession with precision based on a history of bad risk taking (and flat out abuse) within the community and fear of further reputational harm?

Obviously there is some hypothetical combination of virulence and deadliness that would justify this ethically -- what do you think it would be in the eyes of the scientific community?

submitted by /u/meta_mikhail
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Do we know(or at this point, have an educated guess) what factors have an impact on the length of the asymptomatic period of COVID-19 in different individuals?

Posted: 05 Jul 2020 10:58 AM PDT

Can you help me understand what a stretcher is?

Posted: 05 Jul 2020 08:45 AM PDT

Stretchers as part of the Antibody-Drug Conjugates formulas.

Hello! I'm a translator and I'm trying to understand what a "stretcher" is in order to be able to find a suitable translation. All the texts I've found talk about the "stretcher" as something well known, but I don't know them!

If this post is breaking any rule, I'm really sorry.

submitted by /u/Ditania
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On average how old are icebergs estimated to be?

Posted: 05 Jul 2020 06:48 AM PDT

Tried to search through r/askscience, but didn't see anything similar. To clarify how old and any information about how this is determined would be very interesting

submitted by /u/ndrwgrffn
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How does a vacuum pump work?

Posted: 05 Jul 2020 06:24 AM PDT

Like any primitive vacuum pump. Not necessarily the complex modern ones. I don't get how all air molecules can be removed from a container.

submitted by /u/lord_archimond
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Will we get sufficient oxygen, if we wear the face mask through out the day during pandemic?

Posted: 05 Jul 2020 10:12 PM PDT

Actually, which face mask we should prefer? Clinical or cloth mask? By wearing, whether we will get sufficient oxygen for inhalation?

submitted by /u/samchem486
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Sunday, July 5, 2020

Does immunity from a virus get remembered for longer if a recovered person is exposed continually to it?

Does immunity from a virus get remembered for longer if a recovered person is exposed continually to it?


Does immunity from a virus get remembered for longer if a recovered person is exposed continually to it?

Posted: 04 Jul 2020 05:05 PM PDT

I read somewhere else that after recovery, immunity from covid19 lasts around three months. Which is the amount of time our immune system spends resources on creating antibodies specific to that virus.

However, does that take in account if the person is continually exposed to infected people? Is it possible for her/his immune system to get a "memory refresh"? Something like a signal in the body that says "hey, I know you can't remember coronaviruses well but you still need immunity for this"?

submitted by /u/frostwarrior
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Noob Question about virus, Why there is no vaccine for HIV or any sexually transmitted disease?

Posted: 05 Jul 2020 12:54 AM PDT

How do we know that the universe is 14 billion years old?

Posted: 04 Jul 2020 05:52 PM PDT

Edit: So, if we can "look back"(I know I'm drastically oversimplifying) using all of the techniques listed, can we determine WHERE the big bang happened?

submitted by /u/dk_jr
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Are there any viruses/parasites out there that have evolved to benefit their host?

Posted: 05 Jul 2020 12:02 AM PDT

viruses/parasites typically cause harm and even death to their hosts while feeding off them but in doing so they weaken the host to a point where they are not working at full capacity and consequently limit it's own lifespan . I understand that in doing so it hinders the immune system of the host and allows it'self more of a fighting chance to spread throughout the body - but what if the effects of the virus were beneficial instead of harmful in order to allow itself a longer lifespan on a higher-functioning host?

What if a virus boosted muscle growth or acted as a sort of secondary immune system by targeting other parasites/viruses that attempt to infect the host ? I'm not talking full-on superhuman strength or an extra 4 inches where they're needed , just a little extra bump on the stats .

Is there anything out there that does something similar or could evolve to do so?

submitted by /u/Rochester_II
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If the ice caps melt, how much land will still be above the water?

Posted: 04 Jul 2020 10:01 PM PDT

How to find the most common oxidation states of transition elements?

Posted: 05 Jul 2020 03:43 AM PDT

In order to find the conductivity ( p - type or n - type ) in semiconductors such as V2O5 or CuBr i have to know if the oxidation state of the element is maximum or minimum. The d block elements have multiple oxidation states eg: Cr from +2 up to +6 but I should be able to find the most common ones which are +2 (minimum) +3 (maximum). Is there any general rule ?

submitted by /u/knulakethrowawaki
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What’s the difference in the terms, pandemic, plague and outbreak?

Posted: 05 Jul 2020 06:02 AM PDT

Is there COVID-19 statistics controversy ?

Posted: 05 Jul 2020 01:55 AM PDT

Has anyone an explanation how it is possible that COVID-19 cases worldwide are growing daily, but less people die of it ? Is the virus less deadly today then in the beginning or are we better equipped by now ? https://imgur.com/QwbfCww

submitted by /u/oroost
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Are positive cases and positive tests results the same thing?

Posted: 05 Jul 2020 03:41 AM PDT

I see different reporting adjectives regarding positive test results. Right now cnn is reporting 2,795,163 total cases, but my understanding of that number is that those are positive tests. Is it true that people would be tested numerous times once they test positive? It seems that In order to be considered recovered, a patient would have to have a negative test result. This would presume that they may have several positive tests along the way. In short, my question is: are the numbers reported people with the virus or total numbers of positive tests. If it is positive tests, therefore fewer actual people, the death toll would be higher, no?

submitted by /u/lisadee1
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Ongoing health issues after Coronavirus recovery?

Posted: 04 Jul 2020 11:10 PM PDT

It seems so many people have recovered which is great news. Although the government's keep saying it can also be deadly for young healthy people, is this still considered rare?

Does everyone who recovers have some sort of ongoing health issue after they recover from Coronavirus? (Damaged lungs, heart, pancreas etc.). This scares me and I hope that most make a full recovery without ongoing health issues?

submitted by /u/staystrong355
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Does covid-19 really give permanent lung damage?

Posted: 04 Jul 2020 02:24 PM PDT

I know that it can give you pneumonia and pneumonia can leave permanent damage in your lungs. Even though that is serious, calling it permenant is a bit of a scare tactic. Studies show that generally any healthy person's lungs would heal any damage within a year or so.

However I have now seen a few articles (not scientific studies) that seem to imply that covid may leave permanent damage and there is no mention of it being related to pneumonia. Unfortunately with all the propaganda going both ways, I am having trouble sorting the riff from the raff.

Is there any evidence that Covid-19 possibly leaves permanent lung damage that is not from the possible pneumonia?

submitted by /u/realityinhd
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How long do vaccine testing phases last?

Posted: 05 Jul 2020 01:28 AM PDT

I recently read that there are two potential vaccines in the third phase of testing. From my understanding, it's the final phase of testing.

I was just wondering how long does each phase of vaccine testing usually take?

submitted by /u/maqalmulla
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Would a more powerful explosion always have a bigger blast radius?

Posted: 05 Jul 2020 12:28 AM PDT

Just going with regular non-nuclear explosion, would an explosion always have bigger blast radius if its more powerful than the other? Or are there explosives which deal more damage at the point of explosion but don't have as big a blast radius as some other lesser powerful explosion?

submitted by /u/RBT__
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How does the military safely get rid of unexploded bombs?

Posted: 04 Jul 2020 10:19 PM PDT

In movies, they always show the weapons exploding in the air/space or underwater; I don't think that would be good for the environment or marine life, but it's definitely better than something accidentally going off near civilization. Is this an accurate portrayal how bombs are dealt with in real life?

submitted by /u/IndependentPositive8
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Why do people test negative after a few weeks of testing positive for COVID-19?

Posted: 04 Jul 2020 02:07 PM PDT

Sorry if this is a stupid question, but I have HSV-1 and I get seasonal blisters every winter or during times of stress. I will always have it, and the only thing I can do is take care of myself to reduce the frequency of blisters. That being said, I don't know if during dormancy I would test negative for HSV-1. The bare bones that I know about a virus is that it's not likely to go away, it doesn't cycle out like bacterial infections.

So why do COVID-19 patients who survive test negative? Has the virus entered a state of dormancy? Has it cycled out of the host?

submitted by /u/beelzebeaut
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When you look farther in the distance, does the universe look closer together?

Posted: 04 Jul 2020 07:51 AM PDT

How would observing 2 light sources 13 billion light years away work?

submitted by /u/Batgate
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Saturday, July 4, 2020

Influenza vaccines are updated every year. How often are other vaccines updated?

Influenza vaccines are updated every year. How often are other vaccines updated?


Influenza vaccines are updated every year. How often are other vaccines updated?

Posted: 04 Jul 2020 05:19 AM PDT

The influenza vaccine is different from year to year, to match the predicted circulating strains. Is that unique to influenza or are any other vaccines updated in a similar way? For example if I get a tetanus booster this year, is the toxoid different than the one in the booster shot I had ten years ago?

If vaccines do get updated, how often does it happen? If not, how high is the risk that a pathogen will mutate to evade the acquired immunity?

submitted by /u/auraseer
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After a couple months of the pandemic, can we know which epidemiological models have performed 'well'?

Posted: 03 Jul 2020 04:11 PM PDT

Fivethirtyeight currently aggregates 15(!) different COVID models for the U.S., which often give pretty different projections. I understand that just judging the numbers is mostly pointless due to sudden changes in lockdowns and societal behaviors and tweaks to the models themselves, but at this point can we conclude anything about the quality of different models?

submitted by /u/xenneract
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Are HIV patients high risk for COVID19? Or do antiretrovirals have a protective effect?

Posted: 04 Jul 2020 10:36 AM PDT

Why are cloth masks seen as effective considering most cloth masks have micrometer size porosity and viral particles are nanometer in size?

Posted: 04 Jul 2020 12:14 AM PDT

Are hypothermal vents present on the bottom of rivers?

Posted: 04 Jul 2020 10:09 AM PDT

I know hypothermal vents are located on seafloors in volcanically active areas, but is it possible for them to be located on the bottom of rivers?

submitted by /u/iicuriosityii
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Does a shallow continental shelf reduce the power of a tsunami?

Posted: 04 Jul 2020 01:47 AM PDT

I kind of know how tsunamis work, but I'm curious if a wide and shallow continental shelf would have a noticeable impact on the size/strength of a tsunami. From what I understand, a tsunami can travel so far because there's much less resistance in the deep sea, and that when it hits the shelf it starts to rise and slow down, so would a tsunami lose a noticeable amount of energy if it had to travel in shallow waters for a while before hitting a coast?

submitted by /u/Cherry_Winter
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What is the evolutionary or biological benefit of the oesophagus and trachea being right next to each other?

Posted: 04 Jul 2020 12:44 PM PDT

It seems, structurally speaking, that putting a water pipe next to a wind pipe is just asking for disaster - suck water or food down the wrong tube, and you could die. Why are both of these pipes right next to each other? Is there a benefit?

submitted by /u/kuuzo
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According to Maxwell's theory of Electromagnetism, visible light is a combination of fluctuating Electric and Magnetic fields. So why don't we see a compass needle being deflected in the presence of, say, a light bulb?

Posted: 03 Jul 2020 10:43 PM PDT

What is the most difficult part in creating a vaccine for this pandemic at the moment?

Posted: 04 Jul 2020 10:29 AM PDT

How did the Ice Age support huge animals such as Mammoths and other giant versions of today's animals?

Posted: 04 Jul 2020 07:57 AM PDT

The cold would likely hinder plant growth and thus limit food resources available to herbivore species, which carnivores also need to survive.

How were such animals anle to live in that time?

submitted by /u/QuitBSing
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Is particle decay instantaneous?

Posted: 03 Jul 2020 11:21 PM PDT

When a particle decays (say the beta decay of a free neutron) into one or more other particles (and/or energy) does that processes happen instantaneously or is some amount of time required for the process to complete?

Relatedly, if it is not instantaneous is there any metaphor for what is going on that makes sense?

If it is instantaneous are particles vanishing exactly at the moment that other particles instantiate?

Beyond just an answer, can you point me to resources for further reading?

Thank you.

submitted by /u/Revolutionary_Ad_788
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Is there an estimate for number of infections required for the COVID19 virus to mutate enough to start infecting people with immunity again?

Posted: 03 Jul 2020 11:57 AM PDT

From what I understand, if the virus multiplies/mutates long enough - it will eventually become a "different" virus from the perspective of immune system. For flu - this happens pretty much every year. I know that covid is less flexible than flu, so the chance of this happening is much much lower.

Still, has anyone done any research on how many infections would the virus need to reach to have a large enough chance of causing a new wave of infections? Is this even possible to estimate?

submitted by /u/amakai
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What makes SARS-CoV-2 so contagious apart from long incubation period?

Posted: 04 Jul 2020 04:25 AM PDT

Are there any physical properties that make the virus different and more contagious than other Coronavirus es? Or is it just long incubation period and not much else?

submitted by /u/LokiBalboa
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Could a purely analog video signal hold enough data to transmit a 1080 high res video?

Posted: 03 Jul 2020 03:09 PM PDT

I've been watching a bunch of videos on how old tv works and it got me wondering. If we hadn't developed digital signals, could analog signals be pushed to HD levels or is there a physical limit?

Also, wasn't sure if this fit the physics flair, sorry ahead of time.

submitted by /u/boodelwoodel
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When did birds begin to sing?

Posted: 03 Jul 2020 08:38 AM PDT

I know archaeopteryx was the first bird, but did it sing? What is the first birdsong?

submitted by /u/RisingWaterline
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Why are toilets designed to swirl around as they flush?

Posted: 04 Jul 2020 02:09 AM PDT

Why don't they just flush directly down into the center of the bowl?

submitted by /u/QuasarMaster
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With regard to muscular atrophy due to physical inactivity, how does the body select the specific muscle cells to cannibalize?

Posted: 03 Jul 2020 09:23 AM PDT

  • Is it random?
  • Does it select damaged cells?
  • Does it select muscle cells that are rarely utilized?
  • Does it select muscle cells in an area of abundance (large muscle groups)?
submitted by /u/kevshp
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Is the problem with current global warming only that it's happening too fast or that it is happening, regardless of it's speed?

Posted: 03 Jul 2020 04:18 PM PDT

Given that we have experienced large climate variations (ice ages followed by warm periods) over the past millennia, even if we didn't contribute to climate change we would eventually have an earth that is warm enough to cause many problems for us. Is the problem with current global warming only that it happening so fast such that we cannot adjust like we might be able to if it was just natural global warming? or would we not even have global warming during this current period (lets say past 1000 years to next 1000 years) if we didn't put so many greenhouse gases in the atmosphere?

submitted by /u/_honestquestions_
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why doesnt the ISS melt in the thermosphere?

Posted: 03 Jul 2020 03:16 PM PDT

i know there is an answer im just wondering why it doesnt melt in the thermosphere.

submitted by /u/SavageTruths74
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Would it be theoretically possible to eradicate the flu?

Posted: 03 Jul 2020 11:12 AM PDT

I'm aware it mutates a lot and we get new vaccines each year for it.

But if humanity as a whole really tried - if all existing infrastructure was somehow used, could we develop a vaccine or vaccines fast enough, and let's just say this all got funded and that distribution was worked out and every single person in the world who was medically able to be vaccinated actually was - could we eradicate the flu like we did smallpox? And let's say all people also, for the duration, did whatever they could to prevent the spread of it while this world wide vaccination was happening.

Obviously Covid is inspiring this question, as it's just a thing we all have to deal with now, year after year.

submitted by /u/Yggdris
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