What does it take to develop a vaccine, and why does it take so long? | AskScience Blog

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Thursday, February 27, 2020

What does it take to develop a vaccine, and why does it take so long?

What does it take to develop a vaccine, and why does it take so long?


What does it take to develop a vaccine, and why does it take so long?

Posted: 26 Feb 2020 03:02 PM PST

My basic understanding is that a vaccine contains a weakened or dead version of the virus in question, which can be injected into the body so the immune system can develop antibodies without risk of infection. The vaccine acts as a practice run of sorts.

What exactly is it that stops us from just getting a sample of the virus and, say, irradiating it with x-rays or dunking it in some sort of "virus-killer" chemical (if such a thing exists)? Do we have to figure out how to weaken each virus on a case-by-case basis?

I know there obviously must be some reason, and it's not as simple as just bake virus for 15 minutes, until golden brown. Otherwise disease just wouldn't be an issue, and that's obviously not the case. I'm wondering what makes it so hard.

Edit: Thank you for the answers everyone! To sum things up: it's complicated! (Who knew?) But it basically comes down to a whole host of biological factors that I now have a very vague grasp on but am not qualified to summarize (see comments if you want competent biological information), plus a bunch of administrative hurdles.

submitted by /u/merendi1
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Is there any correlation between the frequency of left-handedness in a population and the population's writing system being read right-to-left?

Posted: 26 Feb 2020 06:13 PM PST

I've always assumed most of the languages I encounter are read left-to-right and top-to-bottom due to the majority of the population being right-handed, therefore avoiding smudging when writing. However, when I take into account the fact that many languages are read right-to-left, this connection becomes more tenuous.

Are writing systems entirely a function of culture, or is there evidence for biological/behavioural causes?

submitted by /u/telechronicler
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If E = MC^2 then why does a photon contain energy?

Posted: 27 Feb 2020 03:40 AM PST

Surely 0 x C2 wouldn't work universally, or, I guess the equation wasn't posited as a universal truth to begin with - which is what it's reputation would lead you to believe :p

So what is it really meant to demonstrate?

submitted by /u/FanticalZappy
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Why are Neanderthals (Homo neanderthalensis) a separate species from modern day humans (Homo Sapiens)?

Posted: 26 Feb 2020 01:05 PM PST

I am reading a book that states what separates species is the ability to mate and have fertile offspring. How are Neanderthals and Homo sapiens separate species if we know that Homo sapiens have Neanderthal DNA? Wouldn't the inheriting of DNA require the mating and production of fertile offspring?

submitted by /u/LuchoMucho
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Why is Hydromorphone not called Hydromorphine. Same for hydrocodone why is it not called hydrocodeine? Or are they just not related?

Posted: 26 Feb 2020 04:20 PM PST

What happens during a seizure and what do people feel?

Posted: 26 Feb 2020 08:31 PM PST

Could we be missing a planet on the opposite side of the sun?

Posted: 27 Feb 2020 12:17 AM PST

Is it possible that there is a unknown planet. That is perfectly orbiting the sun on the opposite side? At the same speed of Earth. So its always out of our view? Also if that was the case. Then what other 'space science' would allow us to know?

submitted by /u/unopinionated1
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How are there homologous chromosomes during meiosis?

Posted: 26 Feb 2020 05:53 PM PST

I know that there must be homologous chromosomes during meiosis, as that's what the whole meiosis I is predicated on, but how do you have mother and father chromosomes in your sperm or egg cells?

To the best of my knowledge, meiosis occurs before fertilization (inside your testes or ovary), but you only get both the mother and father chromosomes after fertilization. As homologous chromosomes are the mother and father's pairs of the same chromosome, I don't understand where they come from in meiosis.

I'm sure I'm missing something, but can't figure out what it is.

submitted by /u/benigncancers
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What exactly are "indeterminate growers" (like axolotl and some turtles)? Does this mean that given enough time one would grow as large as an elephant?

Posted: 26 Feb 2020 10:46 AM PST

Also, is this synonymous with negligible senescence? If so, does that mean that even in perfect conditions organisms with negligible senescence will eventually die from becoming too large?

For example, there is this turtle that lived 250+ years and a shark that lived 400+ years. I wonder, after reading this article - https://io9.gizmodo.com/turtles-could-hold-the-secret-to-human-immortality-5618046 - is reference to accidents etc even correct? I've heard that turtles are "indeterminate growers". Does this mean that given enough time any turtle will grow as large as a car (or whatever) and so inevitably mechanically break down and collapse under its own weight? Or not and the reference to accidents/diseases is correct?

submitted by /u/Laroel
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Are there any parasites that alter human behaviour? Like the spinochordodes tellinii in crickets

Posted: 26 Feb 2020 11:09 AM PST

If you were in a ship in space with nothing else in your light cone as a reference point, would it be possible to discern your velocity?

Posted: 26 Feb 2020 07:33 PM PST

Is there anything intrinsic to spacetime which could give information about the rate at which one passes through it?

submitted by /u/bangsecks
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Is it possible to apply Lagrange points to nuclei and electrons?

Posted: 27 Feb 2020 04:16 AM PST

Each nucleus bahaves like a body with its own gravitional pull. And electrons are smaller bodies. We could make an association between two planets and the five asteroids in each langrange point and two nucleii and 5 electrons. Could they behave similarly just at a much smaller scale?

I realize that for this to be possible the weight of the nuclei should be huge compared to the electrons which would imply heavy molecules, which usually have way more than five electrons.

Tho admitting the existence of two atoms which fit the requirements, maybe by extreme extreme izotopisation if that could happen, is it possible that they behave similarly?

submitted by /u/yvaine369
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Do late bloomers/people who mature later generally live longer?

Posted: 26 Feb 2020 03:30 PM PST

Why is g constant regardless of the mass of an object on a planet, but the mass of the planet does matter?

Posted: 26 Feb 2020 06:10 PM PST

At what point does a continent end and how "elevated" is it from the seabed?

Posted: 26 Feb 2020 03:51 PM PST

Let's say you drain all the oceans and are on the furthest point of North America. How far out would you have to walk before you reached the established end of the continent and how far down would the sea floor be? I know it's not necessarily a linear slope nor is it equal in all places but I wanna try and get a rough visualization.

submitted by /u/Merry_Dankmas
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Is there any truth to the "fact" that "If the earth was 10 feet closer to the sun, we'd all burn up." meme?

Posted: 26 Feb 2020 11:01 PM PST

Why do your legs tingle after they've fallen asleep?

Posted: 26 Feb 2020 01:54 PM PST

I get that it's comes from paresthesia? What does that really mean though? I am having a hard time understanding what that actually is.

submitted by /u/IrToken
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How is a nuclear reactor physically built? Not how it works, but how is radioactive material put inside of it?

Posted: 26 Feb 2020 11:17 AM PST

I finally got around to watch the Chernobyl miniseries, and something intrigued me:

If the debris on the roof were so radioactive that neither humans or robots could stay near it for more than a few seconds, how was the radioactive material physically put inside the reactor in the first place? How does that work?

edit: one word

submitted by /u/Le_Mug
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Can you get coronavirus if you had sars?

Posted: 26 Feb 2020 08:45 PM PST

If you got immunity to sars, will that prevent you from the coronavirus since they are similar?

submitted by /u/viewsonic041
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Are people who contract coronavirus immune to it once they end up recovering?

Posted: 26 Feb 2020 08:30 PM PST

There are a few people right now who have contracted covid19 and have recovered from it, are they likely to contract the disease again if they're exposed to the virus?

submitted by /u/A_confusedlover
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Most deadly diseases that humand have (the black plague, coronavirus, and hiv) come from animals. Is there any disease humans gave to animals?

Posted: 26 Feb 2020 10:35 AM PST

How are nerve fibers structured for birds to be able to flap their wings in sync?

Posted: 26 Feb 2020 05:39 PM PST

I know that the structure of nerves for vertebrates and invertebrates are different and I know that stimulus affects the contraction of muscles, but how are the nerve fibers in a bird different? They have to be able to flap both wings at the same time.

submitted by /u/Elitmentary
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How does using hand sanitizer compare to washing one's hands with soap?

Posted: 26 Feb 2020 06:39 AM PST

Have always wondered if one is more effective than the other.

submitted by /u/Killershot9
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